Jump to Main Content
- Chan, Jo-Anne; Howell, Katherine B.; Langer, Christine; Maier, Alexander G.; Hasang, Wina; Rogerson, Stephen J.; Petter, Michaela; Chesson, Joanne; Stanisic, Danielle I.; Duffy, Michael F.; Cooke, Brian M.; Siba, Peter M.; Mueller, Ivo; Bull, Peter C.; Marsh, Kevin; Fowkes, Freya J.I.; Beeson, James G.
- Cellular and molecular life sciences 2016 v.73 no.21 pp. 4141-4158
- Plasmodium falciparum; adults; antibodies; children; epitopes; erythrocytes; genetic engineering; humans; malaria; parasites; phagocytosis; phenotype; pregnant women; protein transport; surface antigens; surface proteins; vaccine development
- ... Antibodies to blood-stage antigens of Plasmodium falciparum play a pivotal role in human immunity to malaria. During parasite development, multiple proteins are trafficked from the intracellular parasite to the surface of P. falciparum-infected erythrocytes (IEs). However, the relative importance of different proteins as targets of acquired antibodies, and key pathways involved in trafficking majo ...
- PubMed Central:
- Jackson, Rebecca A.; Nguyen, Mai Linh; Barrett, Angela N.; Tan, Yuan Yee; Choolani, Mahesh A.; Chen, Ee Sin
- Cellular and molecular life sciences 2016 v.73 no.21 pp. 4001-4017
- risk; proteins; phenotype; enzymes; surveys; biochemical pathways; trisomics; Down syndrome; children; folic acid; apoptosis; single nucleotide polymorphism
- ... Single nucleotide polymorphisms (SNPs) are important biomolecular markers in health and disease. Down syndrome, or Trisomy 21, is the most frequently occurring chromosomal abnormality in live-born children. Here, we highlight associations between SNPs in several important enzymes involved in the one-carbon folate metabolic pathway and the elevated maternal risk of having a child with Down syndrome ...