Jump to Main Content
- Palanca, Ana; Casafont, Iñigo; Berciano, María T.; Lafarga, Miguel
- Cellular and molecular life sciences 2014 v.71 no.10 pp. 1961-1975
- DNA damage; DNA repair; animal models; antineoplastic agents; cytoplasm; dose response; ganglia; genes; neurotoxicity; pathogenesis; patients; peripheral nervous system diseases; proteasome endopeptidase complex; protein synthesis; rats; sensory neurons; transcription (genetics)
- ... Bortezomib is a reversible proteasome inhibitor used as an anticancer drug. However, its clinical use is limited since it causes peripheral neurotoxicity. We have used Sprague–Dawley rats as an animal model to investigate the cellular mechanisms affected by both short-term and chronic bortezomib treatments in sensory ganglia neurons. Proteasome inhibition induces dose-dependent alterations in the ...