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- Bamm, Vladimir V.; Harauz, George
- Cellular and molecular life sciences 2014 v.71 no.10 pp. 1789-1798
- cardiovascular diseases; central nervous system; hemoglobin; iron; iron overload; oxidative stress; pathogenesis; patients; risk factors; sclerosis
- ... Although iron is known to be essential for the normal development and health of the central nervous system, abnormal iron deposits are found in and around multiple sclerosis (MS) lesions that themselves are closely associated with the cerebral vasculature. However, the origin of this excess iron is unknown, and it is not clear whether this is one of the primary causative events in the pathogenesis ...
- Palanca, Ana; Casafont, Iñigo; Berciano, María T.; Lafarga, Miguel
- Cellular and molecular life sciences 2014 v.71 no.10 pp. 1961-1975
- DNA damage; DNA repair; animal models; antineoplastic agents; cytoplasm; dose response; ganglia; genes; neurotoxicity; pathogenesis; patients; peripheral nervous system diseases; proteasome endopeptidase complex; protein synthesis; rats; sensory neurons; transcription (genetics)
- ... Bortezomib is a reversible proteasome inhibitor used as an anticancer drug. However, its clinical use is limited since it causes peripheral neurotoxicity. We have used Sprague–Dawley rats as an animal model to investigate the cellular mechanisms affected by both short-term and chronic bortezomib treatments in sensory ganglia neurons. Proteasome inhibition induces dose-dependent alterations in the ...