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- Schwemmle, Martin, et al. Show all 4 Authors
- Cellular and molecular life sciences 2013 v.70 no.22 pp. 4399-4410
- Borna disease virus; astrocytes; central nervous system; fibroblasts; gene expression; gene expression regulation; genes; hosts; innate immunity; interferon-alpha; mice; neurons; proteins; rats; secretion
- ... Borna disease virus (BDV) persistently infects neurons of the central nervous system of various hosts, including rats. Since type I IFN-mediated antiviral response efficiently blocks BDV replication in primary rat embryo fibroblasts, it has been speculated that BDV is not effectively sensed by the host innate immune system in the nervous system. To test this assumption, organotypical rat hippocamp ...