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You searched for: Journal name Cellular reprogramming Remove constraint Journal name: Cellular reprogramming Publication year rev 7982-2018 Remove constraint Publication year rev: 7982-2018 Source 2018 v.20 no.6 Remove constraint Source: 2018 v.20 no.6
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1. Effects of PRDM14 Silencing on Parthenogenetically Activated Porcine Embryos

Author:
Hui Cheng; Yutian Wang; Jian Zhang; Sheng Zhang; Xiaoling Ma; Xinglan An; Xiaxia Man; Xueming Zhang; Ziyi Li; Bo Tang
Source:
Cellular reprogramming 2018 v.20 no.6 pp. 382-388
ISSN:
2152-4998
Subject:
blastocyst; embryogenesis; epigenetics; females; genes; male fertility; messenger RNA; metaphase; oocytes; parthenogenesis; small interfering RNA; swine
Abstract:
... PRDM14, a member of the PRDM family protein, plays an important role in the regulation of epigenetic reprogramming. Knockdown of Prdm14 in germ cells can lead to female and male subfertility, and the function of PRDM14 appears to be conserved across mammalian species. Thus, we analyzed the expression of Prdm14 in parthenogenetic embryos at all stages of preimplantation and then evaluated the effec ...
DOI:
10.1089/cell.2018.0029

2. Genetically Engineered Adipose Mesenchymal Stem Cells Using HIV-Based Lentiviral Vectors as Gene Therapy for Autoimmune Diseases

Author:
Masoumeh Rostami; Kamran Haidari; Majid Shahbazi
Source:
Cellular reprogramming 2018 v.20 no.6 pp. 337-346
ISSN:
2152-4998
Subject:
CD4-positive T-lymphocytes; autoimmune diseases; bioactive properties; gene therapy; genetic engineering; humans; immunosuppression; inflammation; interleukin-10; interleukin-17; interleukin-23; medicine; mesenchymal stromal cells; mice; quantitative polymerase chain reaction; splenocytes; transcription factors
Abstract:
... The immunomodulatory and self-renewable features of human adipose-derived mesenchymal stem cells (hAD-MSCs) mark their importance in regenerative medicine. Interleukin (IL)-23 as a proinflammatory cytokine suppresses T regulatory cells and promotes the response of T helper 17 and T helper 1 cells. This pathway initiates inflammation and immunosuppression in several autoimmune diseases. The current ...
DOI:
10.1089/cell.2018.0006

3. Kidins220/ARMS Expression Confers Proliferation But Independent of Self-Renewal in Mouse Embryonic Stem Cells

Author:
Jingfeng Luo; Yang Zhou; Qi Chen; Xiaoli Zhao; Ming Zhang
Source:
Cellular reprogramming 2018 v.20 no.6 pp. 365-370
ISSN:
2152-4998
Subject:
RNA interference; embryogenesis; embryonic stem cells; enzymes; genes; genetic markers; mice
Abstract:
... Embryonic stem cells (ESCs) are characterized by their ability to self-renew and their potential to differentiate into any cell type. Therefore, identification of novel molecular markers to verify the pluripotent status of mouse ESCs (mESCs) is of great significance. Kinase D interacting substrate of 220 kDa (Kidins220)/ankyrin repeat-rich membrane spanning (ARMS) plays a crucial role in the integ ...
DOI:
10.1089/cell.2018.0026

4. Generation of Induced Pluripotent Stem Cells from Human Epidermal Keratinocytes

Author:
Yu-Hua Yang; Ru-Zhi Zhang; Sai Cheng; Bin Xu; Ting Tian; Hai-Xia Shi; Li Xiao; Ren-He Chen
Source:
Cellular reprogramming 2018 v.20 no.6 pp. 356-364
ISSN:
2152-4998
Subject:
DNA methylation; Lentivirus; adipocytes; culture dishes; dyes; ectoderm; embryonic stem cells; epidermis (animal); hepatocytes; humans; induced pluripotent stem cells; keratinocytes; mice; staining; therapeutics; transcription factors; transfection
Abstract:
... Induced pluripotent stem cells (iPSCs) play an important role in cell replacement therapy. Several studies have shown that keratinocytes are promising reprogrammed cells. We easily and efficiently enriched epidermal stem cells by attaching them for a limited time in culture dishes. Individual epidermal cells enriched in stem cells, which showed strong immunostaining for K15, were obtained and gene ...
DOI:
10.1089/cell.2018.0035

5. Preparation of Induced Pluripotent Stem Cells Using Human Peripheral Blood Monocytes

Author:
Sumito Isogai; Naoki Yamamoto; Noriko Hiramatsu; Yasuhiro Goto; Masamichi Hayashi; Masashi Kondo; Kazuyoshi Imaizumi
Source:
Cellular reprogramming 2018 v.20 no.6 pp. 347-355
ISSN:
2152-4998
Subject:
induced pluripotent stem cells; Murine respirovirus; genotoxicity; antigens; chromosomes; embryonic germ layers; dendritic cells; humans; monocytes; cytokines; gene expression; genes; fibroblasts; skin (animal)
Abstract:
... Since induced pluripotent stem (iPS) cells have been established, in recent years, clinical transplantation of cells differentiated from iPS cells derived from human skin fibroblasts is been in progress. On the contrary, monocytes have complete genome information without damage and gene recombination, they are contained in the peripheral blood by ∼3%–8% and differentiate into dendritic cells that ...
DOI:
10.1089/cell.2018.0024
PubMed:
31107605
PubMed Central:
PMC6302673

6. Resveratrol Promotes Osteogenic Differentiation of Canine Bone Marrow Mesenchymal Stem Cells Through Wnt/Beta-Catenin Signaling Pathway

Author:
Xiao-e Zhao; Zhenshan Yang; Hui Zhang; Ge Yao; Jie Liu; Qiang Wei; Baohua Ma
Source:
Cellular reprogramming 2018 v.20 no.6 pp. 371-381
ISSN:
2152-4998
Subject:
alkaline phosphatase; beta catenin; bone formation; bone marrow; calcium; dogs; enzyme activity; gene expression; gene expression regulation; genetic markers; glycogen synthase kinases; mesenchymal stromal cells; mitogen-activated protein kinase; resveratrol; signal transduction; tau-protein kinase; tissue engineering
Abstract:
... Bone marrow mesenchymal stem cells (BMSCs) can transdifferentiate into different types of cells and may serve as a cell source for tissue engineering. Resveratrol has been shown to possess many benefits, including activation of osteogenesis. Furthermore, Wnt/β-catenin signaling has been known to promote osteogenic differentiation in many cells. In this study, we investigated the role of resveratro ...
DOI:
10.1089/cell.2018.0032

7. Suprachoroidal Adipose Tissue-Derived Mesenchymal Stem Cell Implantation in Patients with Dry-Type Age-Related Macular Degeneration and Stargardt's Macular Dystrophy: 6-Month Follow-Up Results of a Phase 2 Study

Author:
Ayse Oner; Zeynep Burcin Gonen; Duygu Gülmez Sevim; Neslihan Smim Kahraman; Metin Unlu
Source:
Cellular reprogramming 2018 v.20 no.6 pp. 329-336
ISSN:
2152-4998
Subject:
angiography; color photography; electroretinography; eyes; macular degeneration; mesenchymal stromal cells; patients; stem cells; tomography
Abstract:
... This prospective clinical case series aimed to investigate the safety and efficacy of suprachoroidal adipose tissue-derived mesenchymal stem cell (ADMSC) implantation in patients with dry-type age-related macular degeneration (AMD) and Stargardt's macular dystrophy (SMD). This study included four patients with advanced-stage dry-type AMD and four patients with SMD who underwent suprachoroidal impl ...
DOI:
10.1089/cell.2018.0045