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You searched for: Journal name Chemical communications Remove constraint Journal name: Chemical communications Publication year rev 7979-2021 Remove constraint Publication year rev: 7979-2021 Source 2021 v.57 no.46 Remove constraint Source: 2021 v.57 no.46
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1. Copper-catalyzed monochloromethylazidation to access transformable terminal alkyl chlorides using stoichiometric BrCH₂Cl

Author:
Ya-Xuan Zhang; Kang-Jie Bian; Ruo-Xing Jin; Chi Yang; Xi-Sheng Wang
Source:
Chemical communications 2021 v.57 no.46 pp. 5666-5669
ISSN:
1364-548X
Subject:
alkenes; bioactive compounds; stoichiometry
Abstract:
... Efficient copper-catalyzed 1,2-difunctionalization of alkenes with commercially available BrCH₂Cl as a chloromethylating source was carried out, in which mild conditions, high reactivity, excellent functional-group tolerance, and late-stage modification of a bioactive molecule are demonstrated. This strategy offers a solution for the diverse syntheses of nitrogen-containing terminal alkyl chloride ...
DOI:
10.1039/d1cc01751a

2. Cryogenic activity and stability of benzaldehyde lyase enzyme in lipidic mesophases-nanoconfined water

Author:
Tao Zhou; Yang Yao; Qin Zhang; Raffaele Mezzenga
Source:
Chemical communications 2021 v.57 no.46 pp. 5650-5653
ISSN:
1364-548X
Subject:
benzaldehyde; cold; denaturation; enzymes; liquids
Abstract:
... Phytantriol-based lipidic mesophases (LMs) are introduced as a platform for cryoenzymology, which relies on the presence of liquid water in LMs at subzero temperatures. After incorporation into LMs, the model enzyme Benzaldehyde lyase (BAL) shows high cryogenic stability and activity. In contrast, BAL in bulk solution undergoes significant secondary structural transitions caused by low temperature ...
DOI:
10.1039/d1cc01315g

3. Design and synthesis of gene-directed caged cyclic nucleotides exhibiting cell type selectivity

Author:
Akinobu Z. Suzuki; Taichi Sakano; Hirona Sasaki; Rei Watahiki; Masaki Sone; Kazuki Horikawa; Toshiaki Furuta
Source:
Chemical communications 2021 v.57 no.46 pp. 5630-5633
ISSN:
1364-548X
Subject:
cage design; chemical communication; cyclic nucleotides; enzymes; exhibitions; tissues
Abstract:
... We designed a new caging group that can be photoactivated only in the presence of a non-endogenous enzyme when exposed to 405 nm light. Because cells or tissues can be genetically tagged by an exogenously expressed enzyme, this novel method can serve as a strategy for adding targeting abilities to photocaged compounds. ...
DOI:
10.1039/d1cc01405f

4. High shear spheroidal topological fluid flow induced coating of polystyrene beads with C₆₀ spicules

Author:
Matt Jellicoe; Kasturi Vimalanathan; Jason R. Gascooke; Xuan Luo; Colin L. Raston
Source:
Chemical communications 2021 v.57 no.46 pp. 5638-5641
ISSN:
1364-548X
Subject:
fullerene; polystyrenes; thermodynamics; toluene; topology
Abstract:
... Spheroidal spicular like topological fluid flow in an angled vortex fluidic device (VFD) housing a 20 mm diameter tube with a hemispherical base rotating at 4k rpm and tilted at 45° is effective in reducing the thermodynamic equilibrium concentration of fullerene C₆₀ in toluene, with the formation of spicules of the material under continuous flow processing. Under the same operational conditions i ...
DOI:
10.1039/d0cc07165j

5. In vitro studies of deferasirox derivatives as potential organelle-targeting traceable anti-cancer therapeutics

Author:
Axel Steinbrueck; Adam C. Sedgwick; Hai-Hao Han; Michael Y. Zhao; Sajal Sen; Dan-Ying Huang; Yi Zang; Jia Li; Xiao-Peng He; Jonathan L. Sessler
Source:
Chemical communications 2021 v.57 no.46 pp. 5678-5681
ISSN:
1364-548X
Subject:
cancer therapy; chelating agents; fluorescence; lung neoplasms; lysosomes
Abstract:
... We report here strategic functionalization of the FDA approved chelator deferasirox (1) in an effort to produce organelle-targeting iron chelators with enhanced activity against A549 lung cancer cells. Derivative 8 was found to have improved antiproliferative activity relative to 1. Fluorescent cell imaging revealed that compound 8 preferentially localises within the lysosome. ...
DOI:
10.1039/d0cc08156f

6. Late-stage ligand functionalization via the Staudinger reaction using phosphine-appended 2,2′-bipyridine

Author:
Deeb Taher; Jessica R. Wilson; Grayson Ritch; Matthias Zeller; Nathaniel K. Szymczak
Source:
Chemical communications 2021 v.57 no.46 pp. 5718-5721
ISSN:
1364-548X
Subject:
aromatic hydrocarbons; chemical communication; chemical reactions; ligands
Abstract:
... The ability of a phosphine-appended-2,2′-bipyridine ligand ((Ph₂P)₂bpy) to serve as a platform for late-stage ligand modifications was evaluated using tetrahedral (Ph₂P)₂bpyFeCl₂. We employed a post-metalation Staudinger reaction to install a series of functionalized arenes, including those containing Brønsted and Lewis acidic groups. This reaction sequence represents a versatile strategy to both ...
DOI:
10.1039/d1cc01407b

7. Low molecular weight and highly functional RCF lignin products as a full bisphenol a replacer in bio-based epoxy resins

Author:
Korneel Van Aelst; Elien Van Sinay; Thijs Vangeel; Yingtuan Zhang; Tom Renders; Sander Van den Bosch; Joost Van Aelst; Bert F. Sels
Source:
Chemical communications 2021 v.57 no.46 pp. 5642-5645
ISSN:
1364-548X
Subject:
bisphenol A; epoxides; fractionation; lignin; molecular weight; wood
Abstract:
... Herein, we present a full lignocellulose-to-chemicals valorization chain, wherein low molecular weight and highly functional lignin oligomers, obtained from reductive catalytic fractionation (RCF) of pine wood, were used to fully replace bisphenol A (BPA) for synthesizing bio-based epoxy resins. ...
DOI:
10.1039/d1cc02263f

8. Nuclear magnetic resonance characterisation of ionic liquids and organic ionic plastic crystals: common approaches and recent advances

Author:
Haijin Zhu; Luke A. O'Dell
Source:
Chemical communications 2021 v.57 no.46 pp. 5609-5625
ISSN:
1364-548X
Subject:
chemical communication; crystals; electrolytes; energy; exhibitions; image analysis; ionic liquids; measurement; nuclear magnetic resonance spectroscopy
Abstract:
... Ionic liquids, and their solid-state equivalents organic ionic plastic crystals, show many useful and tailorable properties that make them interesting for a wide range of applications including as electrolytes for energy storage devices. Nuclear magnetic resonance spectroscopy and related techniques offer a powerful and versatile toolkit for the characterisation of structure, interactions and dyna ...
DOI:
10.1039/d1cc02151f

9. Pure organic quinacridone dyes as dual sensitizers in tandem photoelectrochemical cells for unassisted total water splitting

Author:
Luze Shen; Shicong Zhang; Haoran Ding; Fushuang Niu; Yanmeng Chu; Wenjun Wu; Yue Hu; Ke Hu; Jianli Hua
Source:
Chemical communications 2021 v.57 no.46 pp. 5634-5637
ISSN:
1364-548X
Subject:
cathodes; dicarboxylic acids; dyes; pH; photosensitizing agents; pyridines
Abstract:
... Pure organic dye QAP-C8 based on quinacridone (QA) with octyl side chains as the donor and pyridine dicarboxylic acid (PDA) as the acceptor was first used in both the photoanode and the photocathode of photoelectrochemical cells. A tandem device with QAP-C8 as the photosensitizer realized overall water splitting and showed a STH of 0.11% under neutral pH conditions without an external bias. ...
DOI:
10.1039/d1cc01570b

10. Quantitative helix handedness bias through a single H vs. CH₃ stereochemical differentiation

Author:
Daniel Bindl; Elisabeth Heinemann; Pradeep K. Mandal; Ivan Huc
Source:
Chemical communications 2021 v.57 no.46 pp. 5662-5665
ISSN:
1364-548X
Subject:
aromatic acids; chemical communication; quinoline; stereochemistry
Abstract:
... A novel chiral aromatic δ-amino acid building block was shown to fully induce handedness in quinoline oligoamide foldamers with the possibility of further increasing the bias by combining multiples of these units in the same sequence. Through its incorporation within the helix, both N- and C-termini are still accessible for further functionalisation. ...
DOI:
10.1039/d1cc01452h

11. Sensitive, general and portable detection of RNAs combining duplex-specific nuclease transduction with an off-shelf signalling platform

Author:
Lulu Guo; Huan Li; Rujian Zhao; Yidan Tang; Bingling Li
Source:
Chemical communications 2021 v.57 no.46 pp. 5714-5717
ISSN:
1364-548X
Subject:
glucose; hybridization; microRNA; point-of-care systems; viruses
Abstract:
... We report a novel RNA sensing platform by combining the RNA:DNA hybridization, duplex-specific nuclease (DSN) amplification, and personal glucose meter (PGM) readout. The so-called DSN–PGM sensing platform is sensitive, specific and general to both microRNA and long virus RNA. The detection procedure is simple and instrument-free, thus holding particular potential in the development of portable an ...
DOI:
10.1039/d1cc01715b

12. Structural revision of a Wnt/β-catenin modulator and confirmation of cannabielsoin constitution and configuration

Author:
Angelina Z. Monroe; William H. Gordon; Jared S. Wood; Gary E. Martin; Jeremy B. Morgan; R. Thomas Williamson
Source:
Chemical communications 2021 v.57 no.46 pp. 5658-5661
ISSN:
1364-548X
Subject:
anisotropy; chemical communication; synthetic products
Abstract:
... In this report, we revise the structure for a previously reported synthetic product proposed to be the 1R,2S-cannabidiol epoxide and reassign it as cannabielsoin using anisotropic NMR and synthetic chemistry methods. These results provide a direct link to the first known biological target and function of cannabielsoin. ...
DOI:
10.1039/d1cc01971f

13. Titanocene pnictinidene complexes

Author:
Malte Fischer; Fabian Reiß; Christian Hering-Junghans
Source:
Chemical communications 2021 v.57 no.46 pp. 5626-5629
ISSN:
1364-548X
Subject:
chemical communication; exhibitions; ligands
Abstract:
... The phospha–Wittig reagent ᴹᵉˢTerPPMe₃ (ᴹᵉˢTer = 2,6-{2,4,6-Me₃–C₆H₂}–C₆H₃) and arsa–Wittig reagent ᴰⁱᵖTerAsPMe₃ (ᴰⁱᵖTer = 2,6-{2,6-iPr₂-C₆H₃}–C₆H₃) have been employed to synthesize the titanocene complexes Cp₂Ti(PMe₃)PnAr (Pn = P, As) with terminal phosphinidene or arsinidene ligands, respectively. Ab initio studies show that the description as singlet biradicaloids in their ground state is warra ...
DOI:
10.1039/d1cc01305j

14. An expedient synthesis of highly functionalized 1,3-dienes by employing cyclopropenes as C₄ units

Author:
Chengzhou Jiang; Jiamin Wu; Jiabin Han; Kai Chen; Yang Qian; Zhengyu Zhang; Yaojia Jiang
Source:
Chemical communications 2021 v.57 no.46 pp. 5710-5713
ISSN:
1364-548X
Subject:
ambient temperature; catalysts; cleavage (chemistry); rhodium; solvents
Abstract:
... An efficient method has been described to synthesize dicarbonyl functionalized 1,3-dienes by cleaving the CC bond of enaminones with cyclopropenes in the presence of a rhodium catalyst. The acetate-substituted cyclopropenes are judiciously chosen as standard C₄ units of 1,3-diene precursors. The reactions are believed to undergo a unique cutting and insertion process, involving a CC bond cleavag ...
DOI:
10.1039/d1cc01254a

15. A layer-by-layer assembled d/l-arginine-calix[4]arene-Si-surface for macroscopic enantio-selective discrimination of (R)/(S)-ibuprofen

Author:
Xiong Li; Yingying Yang; Jiaxin Quan; Jin Zhang; Ming Cheng; Hewei Yan; Siyun Zhang; Lei Yang; Zhiyan Lu; Haibing Li
Source:
Chemical communications 2021 v.57 no.46 pp. 5706-5709
ISSN:
1364-548X
Subject:
adsorption; arginine; droplets; ibuprofen; silica
Abstract:
... Chiral arginine was introduced by layer-by-layer assembly onto a calix[4]arene-diacid modified silica surface to control the adsorption of different kinds of ibuprofen droplets. The droplet of (S)-ibuprofen slid off rapidly, whereas the droplet of (R)-ibuprofen absorbed on the modified surface. ...
DOI:
10.1039/d1cc01307f

16. A new mode of cyclobutenedione ring opening for the synthesis of 2-oxobut-3-enamides and tetrasubstituted furans

Author:
Ryan M. Bennett; Wei Sun; Dharyl C. Wilson; Mark E. Light; David C. Harrowven
Source:
Chemical communications 2021 v.57 no.46 pp. 5694-5697
ISSN:
1364-548X
Subject:
amides; cleavage (chemistry); furans; lithium
Abstract:
... A dichotomy between the additions of organolithiums and lithium amides to cyclobutenediones is described wherein the former give carbonyl addition products while the latter induce ring opening by enone cleavage via O- to C-lithium transfer. This distinct mode of ring scission gives access to 2-oxobut-3-enamides and tetrasubstituted furans. ...
DOI:
10.1039/d1cc02097h

17. Atomically dispersed Pd–Ru dual sites in an amorphous matrix towards efficient phenylacetylene semi-hydrogenation

Author:
Du Sun; Qingyuan Bi; Mingxia Deng; Bingquan Jia; Fuqiang Huang
Source:
Chemical communications 2021 v.57 no.46 pp. 5670-5673
ISSN:
1364-548X
Subject:
catalytic activity; cost effectiveness; crosslinking; hydrogen; hydrogenation; phosphates; styrene; zirconium
Abstract:
... Optimizing the active sites to balance the conversion and selectivity of the target reaction has long been a challenging quest in developing noble metal-based catalysts. By dispersing Pd and Ru in an amorphous zirconium hydrogen phosphate matrix cross-linked by ionic inorganic oligomers, highly diluted noble metal (<0.2 mol%) can be utilized as dual single-atom sites in oxides for the semi-hydroge ...
DOI:
10.1039/d1cc00923k

18. Covalent organic framework-engineered polydopamine nanoplatform for multimodal imaging-guided tumor photothermal-chemotherapy

Author:
Peng Gao; Ruyue Wei; Xiaohan Liu; Yuanyuan Chen; Tong Wu; Mingwan Shi; Mengzhen Wang; Na Li; Bo Tang
Source:
Chemical communications 2021 v.57 no.46 pp. 5646-5649
ISSN:
1364-548X
Subject:
drugs; neoplasms; therapeutics
Abstract:
... A covalent organic framework (COF)-engineered polydopamine core–shell nanoplatform (PDA@COF) was developed. The ultrasmall pores and abundant functional sites of the COF endowed the nanoplatform with enhanced drug loading capacity and diminished drug leakage effect. Multimodal imaging-guided photothermal chemo-synergistic tumor-targeted therapy was realized after rational functionalization. This w ...
DOI:
10.1039/d1cc00314c

19. Designing SAPO-18 with energetically favorable tetrahedral Si ions for an MTO reaction

Author:
Meiting Wen; Li Ren; Jingyan Zhang; Jingang Jiang; Hao Xu; Yejun Guan; Peng Wu
Source:
Chemical communications 2021 v.57 no.46 pp. 5682-5685
ISSN:
1364-548X
Subject:
energy; silicon; zeolites
Abstract:
... The silicon site location in silicoaluminophosphate zeolites has significant influences on their acidic and catalytic properties. Herein, AEI analogue silicoaluminophosphates with controlled tetrahedral silicon centers (T sites) were synthesized using specially designed amines as expected organic structure-directing agents (OSDAs). DFT calculations show that the OSDAs with different electronegativ ...
DOI:
10.1039/d1cc01140e

20. Highly enantioselective tandem cycloisomerization/Diels–Alder reaction of 2-(1-alkynyl)-2-alken-1-ones and enals: dual catalysis with platinum and amines

Author:
Liejin Zhou; Lu Liu
Source:
Chemical communications 2021 v.57 no.46 pp. 5690-5693
ISSN:
1364-548X
Subject:
catalytic activity; dehydrogenation; enantioselective synthesis; enantioselectivity; platinum
Abstract:
... Herein, we disclosed a highly efficient strategy of enantioselective synthesis of 2,3-furan-fused carbocycles bearing three-contiguous stereocenters. This transformation is catalyzed by dual catalysis of PtCl₄/chiral amines via tandem dehydrogenative annulation/Diels–Alder reaction of 2-(1-alkynyl)-2-alken-1-ones and enals. The in situ generation of the furan-based ortho-quinodimethane intermediat ...
DOI:
10.1039/d1cc02080c