Jump to Main Content
- Stevenson, Clare E. M., et al. Show all 5 Authors
- Chemical communications 2016 v.52 no.99 pp. 14306-14309
- Aspergillus japonicus; biosynthesis; chemical reactions; ergot alkaloids; fungi; oxidoreductases
- ... Aj_EasH is a non-heme iron- and α-keto-glutarate-dependent oxidase that is responsible for an unusual cyclopropyl ring formation in the biosynthesis of the fungal ergot alkaloid cycloclavine. The three dimensional structure of Aj_EasH (2.2 Å resolution) reported here provides insight into the mechanism of this unusual and complex reaction. ...