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- Hou, Lili, et al. Show all 7 Authors
- Chemosphere 2018 v.199 pp. 718-727
- Western blotting; acetylcysteine; aflatoxin B1; cell lines; confocal laser scanning microscopy; crops; feeds; grains; humans; immunotoxicity; interleukin-6; lactate dehydrogenase; macrophages; ochratoxin A; oxidative stress; phosphorylation; reactive oxygen species; signal transduction; swine; transcription factor NF-kappa B; tumor necrosis factor-alpha
- ... The co-contamination of cereals, grains, crops, and animal feeds by mycotoxins is a universal problem. Humans and animals are exposed to several mycotoxins simultaneously as evidenced by extensive studies on this topic. Yet, most studies have addressed the effects of mycotoxins individually. Aflatoxin B1 and ochratoxin A can induce immunotoxicity. However, it remains unclear whether a combination ...
- Hou, Lili, et al. Show all 6 Authors
- Chemosphere 2017 v.182 pp. 630-637
- apoptosis; cytotoxicity; dose response; humans; immunotoxicity; mitogen-activated protein kinase; nephrotoxicity; ochratoxin A; phosphorylation; signal transduction; small interfering RNA; splenocytes; swine
- ... Ochratoxin A (OTA) is reported to be a potent nephrotoxin and immunotoxin in animals and humans. However, the mechanisms underlying OTA toxicity have not been clearly determined until now. Toxicity of OTA and its mechanism was investigated in PK15 cells and in porcine primary splenocytes. The results showed that OTA at 2.0–8.0 μg/mL for 24 h induced cytotoxicity and apoptosis in a dose-dependent m ...