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You searched for: Journal Chinese journal of natural medicines Remove constraint Journal: Chinese journal of natural medicines Publication Year 2019 Remove constraint Publication Year: 2019 Source 2019 v.17 no.4 Remove constraint Source: 2019 v.17 no.4
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1. A novel approach based on metabolomics coupled with network pharmacology to explain the effect mechanisms of Danggui Buxue Tang in anaemia

Author:
HUA, Yong-Li; MA, Qi; YUAN, Zi-Wen; ZHANG, Xiao-Song; YAO, Wan-Ling; JI, Peng; HU, Jun-Jie; WEI, Yan-Ming
Source:
Chinese journal of natural medicines 2019 v.17 no.4 pp. 275-290
ISSN:
1875-5364
Subject:
Oriental traditional medicine; S-adenosylmethionine; anemia; apoptosis; arachidonic acid; biochemical pathways; blood; chemical constituents of plants; cyclophosphamide; cysteine; databases; genes; genetic similarity; hematopoiesis; inflammation; iron; laboratory animals; liquid chromatography; mass spectrometry; metabolites; metabolomics; oxygen; pharmacology; phosphatidylcholines; protein-protein interactions; proteins; rats; reactive oxygen species; signal transduction; therapeutics
Abstract:
... Danggui Buxue Tang (DBT) is a famous Chinese medicinal decoction. Mechanism of DBT action is wide ranging and unclear. Exploring new ways of treatment with DBT is useful. Sprague-Dawley(SD) rats were randomly divided into 3 groups including control (NC, Saline), the DBT (at a dose of 8.10 g−1), and blood deficiency(BD) (Cyclophosphamide (APH)-andCyclophosphamide(CTX)-induced anaemia). A metabolomi ...
DOI:
10.1016/S1875-5364(19)30031-7

2. Astragalus membranaceus improves therapeutic efficacy of asthmatic children by regulating the balance of Treg/Th17 cells

Author:
WANG, Wei; LIU, Qing-Bin; JING, Wei
Source:
Chinese journal of natural medicines 2019 v.17 no.4 pp. 252-263
ISSN:
1875-5364
Subject:
Astragalus membranaceus; Oriental traditional medicine; asthma; blood serum; childhood; children; density gradient centrifugation; flow cytometry; formononetin; genistein; high performance liquid chromatography; immunoglobulin E; interleukin-17; interleukin-23; isoquercitrin; isorhamnetin; kaempferol; lung function; mononuclear leukocytes; quercetin; remission; swine; therapeutics; transforming growth factor beta
Abstract:
... Astragalus membranaceus may be a potential therapy for childhood asthma but its driving mechanism remains elusive. The main components of A. membranaceus were identified by HPLC. The children with asthma remission were divided into two combination group (control group, the combination of budesonide and terbutaline) and A. membranaceus group (treatment group, the combination of budesonide, terbutal ...
DOI:
10.1016/S1875-5364(19)30029-9

3. Eight new cytotoxic annonaceous acetogenins from the seeds of Annona squamosa

Author:
MA, Cheng-Yao; LU, Jia-Hui; LI, Xiang; LIU, Xiao; CHEN, Jian-Wei
Source:
Chinese journal of natural medicines 2019 v.17 no.4 pp. 291-297
ISSN:
1875-5364
Subject:
Annona squamosa; Oriental traditional medicine; acetogenins; cell lines; cytotoxicity; multiple drug resistance; seeds; spectral analysis
Abstract:
... Eight new annonaceous acetogenins, squamotin A-D (1–4), annosquatin IV-V (5 and 6), muricin O (7) and squamosten B (8), together with four known ones (9–12) were isolated from the seeds of Annona squamosa. Their structures were elucidated by chemical methods and spectral data. The inhibitory activities of compound 1–9 against three multidrug resistance cell lines were evaluated. All tested compoun ...
DOI:
10.1016/S1875-5364(19)30032-9

4. Involvement of mitochondrial apoptotic pathway and MAPKs/NF-κ B inflammatory pathway in the neuroprotective effect of atractylenolide III in corticosterone-induced PC12 cells

Author:
GONG, Wen-Xia; ZHOU, Yu-Zhi; QIN, Xue-Mei; DU, Guan-Hua
Source:
Chinese journal of natural medicines 2019 v.17 no.4 pp. 264-274
ISSN:
1875-5364
Subject:
Oriental traditional medicine; antineoplastic activity; apoptosis; calcium; cell viability; corticosterone; lactate dehydrogenase; mitochondria; neuroprotective effect; rats; rhizomes; sesquiterpenoids; therapeutics
Abstract:
... Atractylenolide III (ATL-III), a sesquiterpene compound isolated from Rhizoma Atractylodis Macrocephalae, has revealed a number of pharmacological properties including anti-inflammatory, anti-cancer activity, and neuroprotective effect. This study aimed to evaluate the cytoprotective efficiency and potential mechanisms of ATL-III on corticosterone injured rat phaeochromocytoma (PC12) cells. Our re ...
DOI:
10.1016/S1875-5364(19)30030-5

5. Jatrogricaine A: a new diterpenoid with a 5/6/6/4 carbon ring system from the stems of Jatropha podagrica

Author:
CHEN, Lin; HUANG, Jia-Luo; ZHANG, Lei; TIAN, Hai-Yan; YIN, Sheng
Source:
Chinese journal of natural medicines 2019 v.17 no.4 pp. 298-302
ISSN:
1875-5364
Subject:
Jatropha podagrica; Oriental traditional medicine; anti-inflammatory activity; carbon; diterpenoids; inhibitory concentration 50; lipopolysaccharides; macrophages; nitric oxide; quercetin; spectroscopy; stems
Abstract:
... Jatrogricaine A (1), a new diterpenoid possessing a 5/6/6/4 carbon ring system, together with eight known diterpenoids (2–9) were isolated from the stems of Jatropha podagrica. Their structures were elucidated by extensive spectroscopic methods and the absolute configuration of 1 was determined by single crystal X-ray diffraction analysis. All compounds were evaluated for their anti-inflammatory a ...
DOI:
10.1016/S1875-5364(19)30033-0

6. New octadecanoid derivatives from the seeds of Ipomoea nil

Author:
SONG, Xiu-Qing; ZHANG, Jun-Sheng; YU, Shu-Juan; YU, Jin-Hai; ZHANG, Hua
Source:
Chinese journal of natural medicines 2019 v.17 no.4 pp. 303-307
ISSN:
1875-5364
Subject:
Ipomoea nil; Oriental traditional medicine; acarbose; antioxidant activity; bioassays; enantiomers; enzyme inhibition; inhibitory concentration 50; seeds; spectral analysis
Abstract:
... Four new octadecanoid derivatives (1–4) including a pair of enantiomers (1/2), along with 12 known analogues (5–16), were isolatedfrom the seeds of Ipomoea nil. Their structures were determined by detailed spectroscopic analyses and comparison with reported data of structurally related compounds, with the absolute configurations of 1 and 2 being assigned by an in situ dimolybdenum ECD method. Our ...
DOI:
10.1016/S1875-5364(19)30034-2

7. Rapid discovery and identification of the anti-inflammatory constituents in Zhi-Shi-Zhi-Zi-Chi-Tang

Author:
WANG, Hai-Qiang; ZHU, Yun-Xiang; LIU, Yi-Ning; WANG, Ruo-Liu; WANG, Shu-Fang
Source:
Chinese journal of natural medicines 2019 v.17 no.4 pp. 308-320
ISSN:
1875-5364
Subject:
Oriental traditional medicine; active ingredients; anti-inflammatory activity; flavones; liquid chromatography; mass spectrometry; nuclear magnetic resonance spectroscopy; prediction
Abstract:
... The anti-inflammatory active ingredients of Zhi-Shi-Zhi-Zi-Chi-Tang (ZSZZCT), a traditional Chinese medicine formula, were predicted and identified using an approach based on activity index, LC-MS, semi-preparative LC and NMR. Firstly, the whole extract of ZSZZCT was analyzed using liquid chromatography-quadrupole time of flight-mass spectrometry (LC-Q-TOF-MS) and liquid chromatography - ion trap ...
DOI:
10.1016/S1875-5364(19)30035-4

8. Roles of integrin in tumor development and the target inhibitors

Author:
LI, Zhao-He; ZHOU, You; DING, You-Xiang; GUO, Qing-Long; ZHAO, Li
Source:
Chinese journal of natural medicines 2019 v.17 no.4 pp. 241-251
ISSN:
1875-5364
Subject:
Oriental traditional medicine; adhesion; angiogenesis; carcinogenesis; cell adhesion molecules; cell differentiation; cell movement; cell proliferation; drugs; extracellular matrix; integrins; neoplasm cells; neoplasms
Abstract:
... Integrin is a large family of cell adhesion molecules (CAMs) which involves in the interaction of cells/cells and cells/ extracellular matrix (ECM) to mediate cell proliferation, differentiation, adhesion, migration, etc. In recent years, aberrant expression of integrin has been clearly found in many tumor studies, indicating that integrin is closely related to tumor formation and development. Mea ...
DOI:
10.1016/S1875-5364(19)30028-7