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Chinese journal of natural medicines
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Publication year rev
7981-2019
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2019 v.17 no.8
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- Author:
- Yu-Ru TONG; Yi-Feng ZHANG; Yu-Jun ZHAO; Tian-Yuan HU; Jia-Dian WANG; Lu-Qi HUANG; Wei GAO
- Source:
- Chinese journal of natural medicines 2019 v.17 no.8 pp. 575-584
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; RNA interference; Tripterygium wilfordii; acetyl coenzyme A; active sites; biochemical pathways; biosynthesis; complementary DNA; electrostatic interactions; gene overexpression; genes; hydroxymethylglutaryl-CoA synthase; terpenoids
- Abstract:
- ... 3-Hydroxy-3-methylglutaryl-CoA synthase (HMGS) is the first committed enzyme in the MVA pathway and involved in the biosynthesis of terpenes in Tripterygium wilfordii. The full-length cDNA and a 515 bp RNAi target fragment of TwHMGS were ligated into the pH7WG2D and pK7GWIWG2D vectors to respectively overexpress and silence, TwHMGS was overexpressed and silenced in T. wilfordii suspension cells us ...
- DOI:
- 10.1016/S1875-5364(19)30059-7
- https://doi.org/10.1016/S1875-5364(19)30059-7
- Author:
- Yu-Ze LI; Bei SONG; Xu-Dong ZHENG; Wen-Li HUANG; Hua-Wei ZHANG; Yi JIANG; Zheng-Gang YUE; Xiao-Mei SONG; Jian-Li LIU
- Source:
- Chinese journal of natural medicines 2019 v.17 no.8 pp. 624-630
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; cytotoxicity; human cell lines; humans; inhibitory concentration 50; neoplasm cells; physicochemical properties; rhizomes; roots; saponins; spectral analysis
- Abstract:
- ... Five new polyhydroxylated furostanol saponins were isolated from the roots and rhizomes of Tupistra chinensis, and their structures were determined as tupistrosides J–N (1–5), together with four known furostanol saponins (6–9), on the basis of physico-chemical properties and spectral analysis. Among them, compounds 3 and 5 showed cytotoxicity against human cancer cell lines SW620 with IC50 values ...
- DOI:
- 10.1016/S1875-5364(19)30065-2
- https://doi.org/10.1016/S1875-5364(19)30065-2
- Author:
- Zheng LI; Qian-Qian CHEN; Christopher Wai Kei LAM; Jian-Ru GUO; Wei-Jia ZHANG; Cai-Yun WANG; Vincent Kam Wai WONG; Mei-Cun YAO; Wei ZHANG
- Source:
- Chinese journal of natural medicines 2019 v.17 no.8 pp. 608-615
- ISSN:
- 1875-5364
- Subject:
- DNA replication; Oriental traditional medicine; adenocarcinoma; antineoplastic activity; cell cycle checkpoints; cell lines; cytotoxicity; epithelial cells; humans; hydroxyurea; interphase; liquid chromatography; lungs; mass spectrometry; metabolism; metabolomics; nucleosides; resveratrol
- Abstract:
- ... In an effort to understand the molecular events contributing to the cytotoxicity activity of resveratrol (RSV), we investigated its effects on human lung adenocarcinoma epithelial cell line A549 at different concentrations. Cellular nucleoside metabolic profiling was determined by an established liquid chromatography-mass spectrometry method in A549 cells. RSV resulted in significant decreases and ...
- DOI:
- 10.1016/S1875-5364(19)30063-9
- https://doi.org/10.1016/S1875-5364(19)30063-9
- Author:
- Chang-Liang YAO; Zheng-Ming QIAN; Wen-Shuai TIAN; Xiao-Qian XU; Yu YAN; Yao SHEN; Song-Mao LU; Wen-Jia LI; De-An GUO
- Source:
- Chinese journal of natural medicines 2019 v.17 no.8 pp. 631-640
- ISSN:
- 1875-5364
- Subject:
- Ophiocordyceps sinensis; Oriental traditional medicine; amino acids; chemical species; databases; dipeptides; high performance liquid chromatography; mass spectrometry; nucleobases; nucleosides; quality control; rapid methods; reference standards; ultra-performance liquid chromatography
- Abstract:
- ... Characterization of aqueous extract in traditional Chinese medicine (TCM) is challenging due to the poor retention of the analytes on conventional C18 columns. This study presents a systematic characterization method based on a rapid chromatographic separation (8 min) on a polar-modified C18 (Waters Cortecs T3) column of aqueous extract of Cordyceps sinensis. UHPLC-HRMS method was used to profile ...
- DOI:
- 10.1016/S1875-5364(19)30066-4
- https://doi.org/10.1016/S1875-5364(19)30066-4
- Author:
- Miao LIU; Xi-Wen LI; Bao-Sheng LIAO; Lu LUO; Yue-Ying REN
- Source:
- Chinese journal of natural medicines 2019 v.17 no.8 pp. 585-590
- ISSN:
- 1875-5364
- Subject:
- DNA barcoding; Oriental traditional medicine; adulterants; genetic distance; internal transcribed spacers; medicinal plants; monophyly; sequence alignment; species identification; topology
- Abstract:
- ... The aim is to select a universal DNA barcode for identifying all poisonous medicinal plants in Chinese pharmacopoeia and their poisonous related species or adulterants. We chose 4 commonly used regions as candidate DNA barcodes (ITS2, psbA-trnH, matK and rbcL) and compared their identification efficiency in 106 species from 27 families and 65 genera totally. Data analysis was performed including t ...
- DOI:
- 10.1016/S1875-5364(19)30060-3
- https://doi.org/10.1016/S1875-5364(19)30060-3
- Author:
- Shen-Hong REN; Zhao-Jun LIU; Yuan CAO; Yi HUA; Cong CHEN; Wei GUO; Yi KONG
- Source:
- Chinese journal of natural medicines 2019 v.17 no.8 pp. 591-599
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; agonists; bioactive properties; blood coagulation; collagen; complementary DNA; cutting; hemorrhage; liquid chromatography; mass spectrometry; mice; models; peptides; platelet aggregation; proteome; rats; salivary glands; tail; therapeutics; thrombosis; transcriptome; venoms
- Abstract:
- ... Whitmania pigra has been used as a traditional Chinese medicine (TCM) for promoting blood circulation, alleviating blood coagulation, activating meridians and relieving stasis for several hundred years. However, the therapeutic components of this species, especially proteins and peptides were poorly exploited. Until now only a few of them were obtained by using chromatographic isolation and purifi ...
- DOI:
- 10.1016/S1875-5364(19)30061-5
- https://doi.org/10.1016/S1875-5364(19)30061-5
- Author:
- Wei LIU; Ran YAN; Liang ZHANG
- Source:
- Chinese journal of natural medicines 2019 v.17 no.8 pp. 600-607
- ISSN:
- 1875-5364
- Subject:
- Dendrobium; Oriental traditional medicine; blood serum; dysbiosis; enzyme-linked immunosorbent assay; immunomodulators; interferon-gamma; interleukin-6; intestinal microorganisms; macrophages; mice; patients; phagocytosis; polysaccharides; ribosomal RNA; sequence analysis; toxicity testing; tumor necrosis factor-alpha; viability
- Abstract:
- ... To recognize the potential medicinal value of the Dendrobium sonia, polysaccharide (DSP) was extracted, purified, and investigated for its immunomodulatory activity. In vitro, DSP was shown to enhance the viability (MTT assay) and phagocytosis of macrophages. In cyclophosphamide-induced immunosuppressed mice, DSP increased serum levels of TNF-α, IL-6 and IFN-γ (enzyme-linked immunosorbent assay, E ...
- DOI:
- 10.1016/S1875-5364(19)30062-7
- https://doi.org/10.1016/S1875-5364(19)30062-7
- Author:
- Mei-Yu LIN; Zhong-Lan YUAN; Dan-Dan HU; Gan-Hai HU; Ri-Li ZHANG; Hua ZHONG; Lan YAN; Yuan-Ying JIANG; Juan SU; Yan WANG
- Source:
- Chinese journal of natural medicines 2019 v.17 no.8 pp. 616-623
- ISSN:
- 1875-5364
- Subject:
- Caenorhabditis elegans; Candida albicans; Galleria mellonella; Oriental traditional medicine; adhesion; antifungal properties; biofilm; fungi; gene expression; gene expression regulation; genes; human umbilical vein endothelial cells; hydrophobicity; hyphae; minimum inhibitory concentration; models; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; scanning electron microscopy; toxicity; virulence
- Abstract:
- ... Loureirin A is a major active component of Draconis sanguis, a traditional Chinese medicine. This work aimed to investigate the activity of loureirin A against Candida albicans biofilms. 2, 3-Bis-(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide (XTT)reduction assay and scanning electron microscopy were used to investigate the anti-biofilm effect. Minimal inhibitory concentration te ...
- DOI:
- 10.1016/S1875-5364(19)30064-0
- https://doi.org/10.1016/S1875-5364(19)30064-0
- Author:
- Ying-Qun JIANG; E-Hu LIU
- Source:
- Chinese journal of natural medicines 2019 v.17 no.8 pp. 561-574
- ISSN:
- 1875-5364
- Subject:
- Malvaceae; Oriental traditional medicine; alkaloids; analgesics; bark; bioactive properties; blood lipids; diarrhea; fever; flavonoids; fruits; heat stroke; indigestion; insect bites and stings; insects; jaundice; leaves; organic acids and salts; pharmacology; quality control; roots; shrubs; toxicology; triterpenoids; China; South East Asia
- Abstract:
- ... The shrub Microcos paniulata (MPL; Tiliaceae), distributed in south China, south and southeast Asia, yields a phytomedicine used to treat heat stroke, fever, dyspepsia, diarrhea, insect bites and jaundice. Phytochemical investigations on different parts of MPL indicate the presence of flavonoids, alkaloids, triterpenoids and organic acids. The MPL leaves, fruits, barks and roots extracts showed an ...
- DOI:
- 10.1016/S1875-5364(19)30058-5
- https://doi.org/10.1016/S1875-5364(19)30058-5