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You searched for: Journal name Chinese journal of natural medicines Remove constraint Journal name: Chinese journal of natural medicines Publication year rev 7981-2019 Remove constraint Publication year rev: 7981-2019 Source 2019 v.17 no.9 Remove constraint Source: 2019 v.17 no.9
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1. 3, 4-seco-Labdane diterpenoids from the leaves of Callicarpa nudiflora with anti-inflammatory effects

Author:
Hong-Gang WANG; Fu-Kang LUO; Xiang LEI; Yun-Da YAO; Guo-Chao LIAO; Zhong-Qiu LIU; Zhi-Hong JIANG; Hua ZHOU; Peng WU
Source:
Chinese journal of natural medicines 2019 v.17 no.9 pp. 707-712
ISSN:
1875-5364
Subject:
Callicarpa nudiflora; Oriental traditional medicine; anti-inflammatory activity; dexamethasone; diterpenoids; leaves; nitric oxide; spectral analysis
Abstract:
... Four new 3, 4-seco-labdane diterpenoids, nudiflopenes J-M, were isolated from the leaves of Callicarpa nudiflora along with six known compounds. The structures of these diterpenoids were determined by comprehensive spectroscopic analysis. All the isolated compounds were evaluated for their inhibitory effects on NO production in LPS-stimulated RPMs and RAW264.7 cells. The results suggest that nudif ...
DOI:
10.1016/S1875-5364(19)30085-8

2. New aporphine alkaloids with selective cytotoxicity against glioma stem cells from Thalictrum foetidum

Author:
Cai-Feng DING; Zhi DAI; Hao-Fei YU; Xu-Dong ZHAO; Xiao-Dong LUO
Source:
Chinese journal of natural medicines 2019 v.17 no.9 pp. 698-706
ISSN:
1875-5364
Subject:
Oriental traditional medicine; Thalictrum; cytotoxicity; glioma; inhibitory concentration 50; isoquinoline alkaloids; roots; spectral analysis; stem cells
Abstract:
... Seven new isoquinoline alkaloids, 9-(2′-formyl-5′, 6′-dimethoxyphenoxy)-1, 2, 3, 10-tetramethoxy dehydroaporphine (1), 9-(2′-formyl-5′, 6′-dimethoxyphenoxy)-1, 2, 3, 10-tetramethoxy oxoaporphine (2), 3-methoxy-2′-formyl oxohernandalin (3), (−)-9-(2′-methoxycarbonyl-5′, 6′-dimethoxyphenoxy)-1, 2, 3, 10-tetramethoxy aporphine (4), (−)-2′-methoxycarbonyl thaliadin (5), (−)-9-(2′-methoxyethyl-5′, 6′-d ...
DOI:
10.1016/S1875-5364(19)30084-6

3. Potential hepatic and renal toxicity induced by the biflavonoids from Ginkgo biloba

Author:
Yun-Ying LI; Xiao-Yan LU; Jia-Li SUN; Qing-Qing WANG; Yao-Dan ZHANG; Jian-Bing ZHANG; Xiao-Hui FAN
Source:
Chinese journal of natural medicines 2019 v.17 no.9 pp. 672-681
ISSN:
1875-5364
Subject:
Ginkgo biloba; Oriental traditional medicine; acute kidney injury; alkaline phosphatase; apoptosis; blood serum; cell viability; dose response; epithelial cells; flavonoids; hepatocytes; histopathology; humans; in vivo studies; kidneys; liver; medicinal properties; mice; nephrotoxicity; risk; tissues; toxicity testing
Abstract:
... Evidence continues to grow on potential health risks associated with Ginkgo biloba and its constituents. While biflavonoid is a subclass of the flavonoid family in Ginkgo biloba with a plenty of pharmacological properties, the potential toxicological effects of biflavonoids remains largely unknown. Thus, the aim of this study was to investigate the in vitro and in vivo toxicological effects of the ...
DOI:
10.1016/S1875-5364(19)30081-0

4. Bupleurum polysaccharides ameliorated renal injury in diabetic mice associated with suppression of HMGB1-TLR4 signaling

Author:
Zhen-Zhen LIU; Hong-Bo WENG; Li-Jie ZHANG; Ling-Yu PAN; Wei SUN; Hai-Xia CHEN; Mei-Yu CHEN; Tao ZENG; Yun-Yi ZHANG; Dao-Feng CHEN; Hong LI
Source:
Chinese journal of natural medicines 2019 v.17 no.9 pp. 641-649
ISSN:
1875-5364
Subject:
Bupleurum; Oriental traditional medicine; Toll-like receptor 4; actin; albumins; animal disease models; blood serum; collagen; creatinine; diabetes; excretion; fibronectins; fibrosis; inflammation; interleukin-6; kidney diseases; kidneys; mice; muscles; necrosis; neoplasms; nucleoproteins; oral administration; polysaccharides; renal function; transcription factor NF-kappa B; tumor necrosis factor-alpha
Abstract:
... Bupleurum polysaccharides (BPs) is isolated from Bupleurum smithii var. parvifolium, a key traditional Chinese medicine. The study was to investigate the effects of BPs on diabetic kidney injury. After two intraperitoneal injections of streptozotozin (STZ) 100 mg·kg−1, renal injury in diabetic mice was induced and BPs was orally administrated at dosages of 30 and 60 mg·kg−1·d−1. The STZ injected m ...
DOI:
10.1016/S1875-5364(19)30078-0

5. Exploration of the mechanisms of Ge Gen Decoction against influenza A virus infection

Author:
Zi-Kai GENG; Ya-Qun LI; Qing-Hua CUI; Rui-Kun DU; Jing-Zhen TIAN
Source:
Chinese journal of natural medicines 2019 v.17 no.9 pp. 650-662
ISSN:
1875-5364
Subject:
Influenza A virus; Oriental traditional medicine; Toll-like receptor 7; drugs; histopathology; immune response; immune system; inflammation; lungs; mice; oseltamivir; respiratory tract diseases; signal transduction; survival rate; tumor necrosis factor-alpha
Abstract:
... Ge Gen Decoction (GGD), a Traditional Chinese Medicine prescription, is mainly used to treat infectious respiratory diseases and can relieve the symptoms of influenza A virus (IAV) infection. However, the underlying mechanism of GGD against IAV infection remains unclear. In this study, we found that GGD had moderate anti-IAV activity in vitro. GGD was more effective when given before the viral inf ...
DOI:
10.1016/S1875-5364(19)30079-2
PubMed:
31526500
PubMed Central:
PMC7128581

6. Pyridocarbazole alkaloids from Ochrosia borbonica: lipid-lowering agents inhibit the cell proliferation and adipogenesis of 3T3-L1 adipocyte via intercalating into supercoiled DNA

Author:
Yao-Hao XU; Wei LI; Yong RAO; Zhi-Shu HUANG; Sheng YIN
Source:
Chinese journal of natural medicines 2019 v.17 no.9 pp. 663-671
ISSN:
1875-5364
Subject:
Ochrosia; Oriental traditional medicine; adipocytes; adipogenesis; antilipemic agents; cell proliferation; droplets; fractionation; indole alkaloids; lipogenesis; luteolin; median effective concentration; mitosis; models; monoterpenoids; supercoiled DNA; triacylglycerols
Abstract:
... Bioassay-guided fractionation of an ethanolic extract of Ochrosia borbonica led to the isolation of two known pyridocarbazole alkaloids, ellipticine (1) and 9-methoxyellipticine (2), and six known monoterpenoid indole alkaloids (3–8). Lipid-lowering assay in 3T3-L1 cell model revealed that 1 and 2 could significantly inhibit the lipid droplet formation (EC50 = 0.41 and 0.92 μmol·L−1, respectively) ...
DOI:
10.1016/S1875-5364(19)30080-9

7. Role of kaempferol to increase bioavailability and pharmacokinetics of nifedipine in rats

Author:
Ji-Won PARK; Jin-Seok CHOI
Source:
Chinese journal of natural medicines 2019 v.17 no.9 pp. 690-697
ISSN:
1875-5364
Subject:
Oriental traditional medicine; P-glycoproteins; bioavailability; cytochrome P-450; enzyme activity; experimental design; in vitro studies; inhibitory concentration 50; intravenous injection; kaempferol; liver; metabolites; pharmacokinetics; rats; small intestine
Abstract:
... Herein, the purpose of this study is to evaluate the effects of kaempferol on bioavailability and pharmacokinetics of nifedipine and its metabolite dehydronifedipine in rats. The experimental design is based on with or without kaempferol in the oral and intravenous administration of nifedipine in rats. Moreover, the pharmacokinetic parameters including nifedipine and dehydronifedipine were evaluat ...
DOI:
10.1016/S1875-5364(19)30083-4

8. The inhibition mechanism of the uptake of lamivudine via human organic anion transporter 1 by Stellera chamaejasme L. extracts

Author:
Lan-Ying PAN; Kui ZENG; Li LI; Yan LOU; Su ZENG
Source:
Chinese journal of natural medicines 2019 v.17 no.9 pp. 682-689
ISSN:
1875-5364
Subject:
Oriental traditional medicine; Stellera chamaejasme; antineoplastic activity; antiviral agents; bioavailability; dogs; drugs; excretion; flavones; genes; humans; inhibitory concentration 50; kidneys; lamivudine; pharmacokinetics; physiological transport; plant extracts; rats; roots; transporters
Abstract:
... Stellera chamaejasme L. is a traditional Chinese medicine with a long history to treat stubborn skin ulcer, and it also has antiviral and antitumor effects. Neochamaejasmine B (NCB), Neochamaejasmine A (NCA) and Chamaechromone (CMC) are the major components in dried roots of Stellera chamaejasme L.. Our studies suggested that NCB, NCA and CMC are inhibitors of Organic anion transporter 1 (OAT1). O ...
DOI:
10.1016/S1875-5364(19)30082-2

9. Traditional Chinese medicine extraction method by ethanol delivers drug-like molecules

Author:
William G. Miao; Chunping Tang; Yang Ye; Ronald J. Quinn; Yunjiang Feng
Source:
Chinese journal of natural medicines 2019 v.17 no.9 pp. 713-720
ISSN:
1875-5364
Subject:
Oriental traditional medicine; ethanol; hexane; high performance liquid chromatography; methanol; methylene chloride; nuclear magnetic resonance spectroscopy; physicochemical properties; wines
Abstract:
... Traditional Chinese Medicine (TCM) is an important reservoir for bioactive natural products. TCM extraction methods by water decoction and wine tincture are an integral part of TCM and essential for their widely acknowledged efficacy. In this study, we selected 6 common TCMs that are rich in chemistry to investigate whether the TCM extraction methods deliver molecules with drug-like physical chemi ...
DOI:
10.1016/S1875-5364(19)30086-X