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You searched for: Journal name Chinese journal of natural medicines Remove constraint Journal name: Chinese journal of natural medicines Publication year rev 7984-2016 Remove constraint Publication year rev: 7984-2016 Source 2016 v.14 no.11 Remove constraint Source: 2016 v.14 no.11
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1. Food-advanced glycation end products aggravate the diabetic vascular complications via modulating the AGEs/RAGE pathway

Author:
Xing LV; Gao-Hong LV; Guo-Ying DAI; Hong-Mei SUN; Hui-Qin XU
Source:
Chinese journal of natural medicines 2016 v.14 no.11 pp. 844-855
ISSN:
1875-5364
Subject:
C-reactive protein; Oriental traditional medicine; animal disease models; blood serum; cortex; creatinine; diabetes; diet; endothelial cells; gene expression regulation; glucose; glycation; heart; histology; insulin; interleukin-6; kidneys; low density lipoprotein; messenger RNA; mice; pancreas; pathogenesis; protein content; protein synthesis; streptozotocin; superoxide dismutase; tumor necrosis factor-alpha; urea nitrogen; urine; weight loss
Abstract:
... The aim of this study was to investigate the effects of high-advanced glycation end products (AGEs) diet on diabetic vascular complications. The Streptozocin (STZ)-induced diabetic mice were fed with high-AGEs diet. Diabetic characteristics, indicators of renal and cardiovascular functions, and pathohistology of pancreas, heart and renal were evaluated. AGEs/RAGE/ROS pathway parameters were determ ...
DOI:
10.1016/S1875-5364(16)30101-7

2. Identification of antioxidant activity of two new aromatic ring butyrolactone derivatives from Dictamnus dasycarpus Turcz.

Author:
Li-Na GUO; Yue-Hu PEI; Fei-Xiang XIE; Lei LIU; Huan CONG; Hong-Xia CUI; Xiao-Li WANG; Wen-Jing LI; Bai-Yu JIAN; Ji-Cheng LIU
Source:
Chinese journal of natural medicines 2016 v.14 no.11 pp. 876-880
ISSN:
1875-5364
Subject:
Dictamnus dasycarpus; Oriental traditional medicine; antioxidant activity; aromatic compounds; chemical constituents of plants; inhibitory concentration 50; spectroscopy
Abstract:
... The present study carried out a phytochemical investigation on the root barks of Dictamnus dasycarpus Turcz, leading to the isolation and characterization of two new aromatic ring butyrolactone derivatives, dasycarpusphenol acid A (1) and dasycarpusphenol acid B (2). Their structures were elucidated by using spectroscopic techniques and HR-FAB-MS. Compounds 1 and 2 exhibited antioxidant activity, ...
DOI:
10.1016/S1875-5364(16)30105-4

3. Isolation and characterization of two new 2-isobutylmalates from Bletilla striata

Author:
Huan-Yu GUAN; Yan YAN; Yong-Lin WANG; Ai-Min WANG; Jun-Hong LIU; Xun HE; Yong-Jun LI; Yong HUANG; Shang-Gao LIAO
Source:
Chinese journal of natural medicines 2016 v.14 no.11 pp. 871-875
ISSN:
1875-5364
Subject:
Bletilla striata; Oriental traditional medicine; chromatography; spectral analysis; tubers
Abstract:
... The present study isolated 17 compounds from the tubers of Bletilla striata (Orchidaceae), using various chromatographic techniques. Their structures were identified based on their physical-chemical properties and spectroscopic analyses. Among them, two new 2-isobutylmalates, named bletimalates A (1) and B (2), together with other fifteen known compounds (3–17), were isolated and identified. Addit ...
DOI:
10.1016/S1875-5364(16)30104-2

4. Jiawei Erzhiwan improves menopausal metabolic syndrome by enhancing insulin secretion in pancreatic β cells

Author:
Xiao-Meng WAN; Mu ZHANG; Pei ZHANG; Zhi-Shen XIE; Feng-Guo XU; Ping ZHOU; Shi-Ping MA; Xiao-Jun XU
Source:
Chinese journal of natural medicines 2016 v.14 no.11 pp. 823-834
ISSN:
1875-5364
Subject:
Oriental traditional medicine; adults; amino acids; animal ovaries; animal tissues; antagonists; blood serum; carcinogenesis; cardiovascular diseases; drug therapy; epithelial cells; estrogen receptors; females; glucose; human cell lines; hyperlipidemia; insulin resistance; insulin secretion; islets of Langerhans; mammary glands; menopause; metabolic syndrome; metabolomics; ovariectomy; rats; risk factors
Abstract:
... Menopausal metabolic syndrome (MMS) is a series of syndrome caused by ovarian function decline and hormone insufficiency, and is a high risk factor for cardiovascular diseases (CVD) and type II diabetes mellitus (T2DM). Erzhiwan (EZW), composed of Herba Ecliptae and Fructus Ligustri Lucidi, is a traditional Chinese herbal formula that has been used to treat menopausal syndrome for many years. We a ...
DOI:
10.1016/S1875-5364(16)30099-1

5. Prophylactic effects of alkaloids from Ba lotus seeds on L-NNA-induced hypertension in mice

Author:
Peng SUN; Kai ZHU; Cun WANG; Wei-Wei LIU; De-Guang PENG; Xin ZHAO
Source:
Chinese journal of natural medicines 2016 v.14 no.11 pp. 835-843
ISSN:
1875-5364
Subject:
Nymphaeaceae; Oriental traditional medicine; active ingredients; alkaloids; blood serum; blood vessels; calcium; diastolic blood pressure; drugs; endothelial nitric oxide synthase; endothelins; functional foods; genes; hypertension; inducible nitric oxide synthase; interleukin-1beta; kidneys; liver; malondialdehyde; messenger RNA; mice; models; myocardium; neuronal nitric oxide synthase; nitric oxide; protective effect; reverse transcriptase polymerase chain reaction; seeds; stomach; systolic blood pressure; tumor necrosis factor-alpha; vascular endothelial growth factors
Abstract:
... Alkaloids from Ba lotus seeds (ABLS) are a kind of important functional compounds in lotus seeds. The present study was designed to determine its hypertension prophylactic effects in the L-NNA-induced mouse hypertension model. The mice were treated with ABLS, the serum and tissues levels of NO, MDA, ET-1, VEGF, and CGRP were determined using the experimental kits, the mRNA levels of various genes ...
DOI:
10.1016/S1875-5364(16)30100-5

6. Protective effects of Huanglian Wendan Decoction aganist cognitive deficits and neuronal damages in rats with diabetic encephalopathy by inhibiting the release of inflammatory cytokines and repairing insulin signaling pathway in hippocampus

Author:
Yue-Bi LI; Wei-Hua ZHANG; Hua-Dong LIU; Zhou LIU; Shi-Ping MA
Source:
Chinese journal of natural medicines 2016 v.14 no.11 pp. 813-822
ISSN:
1875-5364
Subject:
Oriental traditional medicine; cognition; cognitive disorders; cytokines; diabetic complications; encephalopathy; hippocampus; insulin; metformin; neurons; protective effect; rats; signal transduction; streptozotocin
Abstract:
... Huanglian Wendan decoction (HLWDD) has been used for the treatment of symptom of “Re”, one of major causes in diabetes and metabolic disorders, according to the theory of traditional Chinese medicine. The present study aimed at investigating the cerebral protective effects of HLWDD on diabetic encephalopathy (DE), one of the major diabetic complications. The effects of HLWDD and metformin were ana ...
DOI:
10.1016/S1875-5364(16)30098-X

7. The phenylalanine ammonia-lyase gene family in Isatis indigotica Fort.: molecular cloning, characterization, and expression analysis

Author:
Rui-Fang MA; Qian-Zi LIU; Ying XIAO; Lei ZHANG; Qing LI; Jun YIN; Wan-Sheng CHEN
Source:
Chinese journal of natural medicines 2016 v.14 no.11 pp. 801-812
ISSN:
1875-5364
Subject:
Escherichia; Isatis tinctoria; Oriental traditional medicine; active sites; bioactive compounds; bioinformatics; biosynthesis; cytosol; databases; elicitors; flowers; leaves; metabolic engineering; molecular cloning; multigene family; phenolic compounds; phenylalanine ammonia-lyase; prediction; protoplasts; quantitative polymerase chain reaction; recombinant proteins; roots; secondary metabolites; stems; surveys; tissues
Abstract:
... Phenolic compounds, metabolites of the phenylpropanoid pathway, play an important role in the growth and environmental adaptation of many plants. Phenylalanine ammonia-lyase (PAL) is the first key enzyme of the phenylpropanoid pathway. The present study was designed to investigate whether there is a multi-gene family in I. Indigotic and, if so, to characterize their properties. We conducted a comp ...
DOI:
10.1016/S1875-5364(16)30097-8
PubMed:
27914524
PubMed Central:
PMC7129711

8. Agglutinin isolated from Arisema heterophyllum Blume induces apoptosis and autophagy in A549 cells through inhibiting PI3K/Akt pathway and inducing ER stress

Author:
Li-Xing FENG; Peng SUN; Tian MI; Miao LIU; Wang LIU; Si YAO; Yi-Min CAO; Xiao-Lu YU; Wan-Ying WU; Bao-Hong JIANG; Min YANG; De-An GUO; Xuan LIU
Source:
Chinese journal of natural medicines 2016 v.14 no.11 pp. 856-864
ISSN:
1875-5364
Subject:
Arisaema; Oriental traditional medicine; agglutinins; antineoplastic activity; apoptosis; autophagy; caspase-3; caspase-9; cell cycle checkpoints; cytotoxicity; humans; hydrophobic interaction chromatography; inflammation; interphase; lung neoplasms; medicinal plants; neoplasm cells; organelles; patients; seizures; staining
Abstract:
... Arisaema heterophyllum Blume is one of the three medicinal plants known as traditional Chinese medicine Rhizoma Arisaematis (RA). RA has been popularly used to treat patients with convulsions, inflammation, and cancer for a long time. However, the underlying mechanisms for RA effects are still unclear. The present study was designed to determine the cytotoxicity of agglutinin isolated from Arisema ...
DOI:
10.1016/S1875-5364(16)30102-9

9. Isochlorogenic acid A affects P450 and UGT enzymes in vitro and in vivo

Author:
Jing WANG; Hong WANG; Ying PENG; Guang-Ji WANG; Hai-Ping HAO
Source:
Chinese journal of natural medicines 2016 v.14 no.11 pp. 865-870
ISSN:
1875-5364
Subject:
Oriental traditional medicine; antiviral properties; enzymes; fruit products; herbal medicines; humans; inhibitory concentration 50; liver microsomes; mice; plant-based foods; vegetables
Abstract:
... Isochlorogenic acid A (ICQA), which has anti-inflammatory, hepatoprotective, and antiviral properties, is commonly presented in fruits, vegetables, coffee, plant-based food products, and herbal medicines. These herbal medicines are usually used in combination with other medicines in the clinic. However, little is known about the regulatory effects of ICQA on drug-metabolizing enzymes and the herb- ...
DOI:
10.1016/S1875-5364(16)30103-0