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Chinese journal of natural medicines
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Publication year rev
7985-2015
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2015 v.13 no.2
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- Author:
- Yan ZHAO; Xiao CHU; Xiao-Bin PANG; Shao-Hua WANG; Guan-Hua DU
- Source:
- Chinese journal of natural medicines 2015 v.13 no.2 pp. 99-107
- ISSN:
- 1875-5364
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; Oriental traditional medicine; adenosine diphosphate; antioxidant activity; coagulation; ferric chloride; free radical scavengers; inferior vena cava; lipid peroxidation; malondialdehyde; mitochondria; models; nitric oxide; oxidation; oxidative stress; platelet aggregation; protective effect; prothrombin; rats; superoxide dismutase; thromboplastin; thrombosis
- Abstract:
- ... The present study was designed to investigate the antithrombotic effects and underlying mechanisms of the effective components group (ECG) of Xiaoshuantongluo recipe (XECG) and to further verify the rationality and feasibility of ECG-guided methodology in traditional Chinese medicine (TCM) research. The arterial thrombosis model induced by ferric chloride (FeCl3) oxidation and the venous thrombosi ...
- DOI:
- 10.1016/S1875-5364(15)60013-9
- https://doi.org/10.1016/S1875-5364(15)60013-9
- Author:
- Shi-Guang WANG; Yan XU; Hao XIE; Wei WANG; Xiao-Hu CHEN
- Source:
- Chinese journal of natural medicines 2015 v.13 no.2 pp. 127-132
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; Western blotting; astragalosides; cardiomyocytes; cell viability; creatine; enzyme activity; enzyme-linked immunosorbent assay; inflammation; interleukin-6; lactate dehydrogenase; lipid peroxidation; lipopolysaccharides; malondialdehyde; messenger RNA; models; phosphates; protective effect; protein synthesis; reverse transcriptase polymerase chain reaction; superoxide dismutase; transcription factor NF-kappa B; tumor necrosis factor-alpha
- Abstract:
- ... This study aimed to investigate the protective effects of astragaloside IV (AS IV) on lipopolysaccharide (LPS)-induced injury in H9C2 cardiomyocytes. H9C2 Cardiomyocytes were cultured with LPS (10 μg·mL⁻¹) for 4 h and treated with AS IV at 50, 100, and 150 μmol·L⁻¹ for various durations. Cell viability was determined by MTT. The content of released TNF-α and IL-6 from cardiomyocytes were evaluated ...
- DOI:
- 10.1016/S1875-5364(15)60016-4
- https://doi.org/10.1016/S1875-5364(15)60016-4
- Author:
- Ping LU; Na-Na WANG; Ji-Mu WU; Pei-Feng XUE
- Source:
- Chinese journal of natural medicines 2015 v.13 no.2 pp. 142-144
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; Syringa; chemical composition; sesquiterpenoids; tetrahydrofuran
- Abstract:
- ... Two new sesquiterpenes, innatifolone A (1) and pinnatifolone B (2), along with 6 known compounds, furostan (3), isocalamendiol (4), pluviatolide (5), (8S,8′R,9S)-cubebin (6), 2-(4-hydroxy-3-methoxybenzyl)-3-(3,4-dimethoxybenzyl) tetrahydrofuran (7), and methyl 3-acetoxy-12-oleanen-28-oate (8), were isolated from Mongolian herb Syringa pinnatifolia. ...
- DOI:
- 10.1016/S1875-5364(15)60018-8
- https://doi.org/10.1016/S1875-5364(15)60018-8
- Author:
- I.A. Oladosu; S.O. Balogun; Zhi-Qiang LIU
- Source:
- Chinese journal of natural medicines 2015 v.13 no.2 pp. 133-141
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; chemical composition; pinitol
- Abstract:
- ... Four new compounds, alloeudesmenol (1), hanocokinoside (3), allotaraxerolide (4), and alloaminoacetaldehyde (5), together with two known compound, stigmastane-3β,4β-diol (2) and pinitol 6 (a and b) were isolated and identified from the whole plant of Allophylus africanus. ...
- DOI:
- 10.1016/S1875-5364(15)60017-6
- https://doi.org/10.1016/S1875-5364(15)60017-6
- Author:
- He HUANG; Shuang-Xi REN; Sheng YANG; Hai-Feng HU
- Source:
- Chinese journal of natural medicines 2015 v.13 no.2 pp. 90-98
- ISSN:
- 1875-5364
- Subject:
- Actinoplanes; Oriental traditional medicine; Streptomyces hygroscopicus; biosynthesis; computer software; genomics; methyltransferases; multigene family; polyketide synthases; rapamycin
- Abstract:
- ... The present study was designed to identify the difference between two rapamycin biosynthetic gene clusters from Streptomyces hygroscopicus ATCC29253 and Actinoplanes sp. N902-109 by comparing the sequence and organization of the gene clusters. The biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus ATCC29253 was reported in 1995. The second rapamycin producer, Actinoplanes sp. N9 ...
- DOI:
- 10.1016/S1875-5364(15)60012-7
- https://doi.org/10.1016/S1875-5364(15)60012-7
- Author:
- Lun WU; Zhi-Li CHEN; Yang SU; Qiu-Hong WANG; Hai-Xue KUANG
- Source:
- Chinese journal of natural medicines 2015 v.13 no.2 pp. 81-89
- ISSN:
- 1875-5364
- Subject:
- Actaea simplex; Oriental traditional medicine; bioactive properties; metabolites; triterpenoid saponins
- Abstract:
- ... The constituents of Cimicifuga plants have been extensively investigated, and the principal metabolites are 9,19-cyclolanostane triterpenoid glycosides, which are distributed widely in Cimicifuga plants, but not in other members of the Ranunculaceae family, and are considered to be characteristics of the Cimicifuga genus. This type of triterpenoid glycoside possesses several important biological a ...
- DOI:
- 10.1016/S1875-5364(15)60011-5
- PubMed:
- 25769890
- PubMed Central:
- PMC7130100
- https://doi.org/10.1016/S1875-5364(15)60011-5
- Author:
- Tian ZI; Dong YU
- Source:
- Chinese journal of natural medicines 2015 v.13 no.2 pp. 108-118
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; active ingredients; animal models; anti-inflammatory activity; computer software; databases; genes; laboratory experimentation; mechanism of action; research and development; rheumatoid arthritis; signal transduction; therapeutics
- Abstract:
- ... We collected the data on the Sendeng-4 chemical composition corresponding targets through the literature and from DrugBank, SuperTarget, TTD (Therapeutic Targets Database) and other databases and the relevant signaling pathways from the KEGG (Kyoto Encyclopedia of Genes and Genomes) database and established models of the chemical composition-target network and chemical composition-target-disease n ...
- DOI:
- 10.1016/S1875-5364(15)60014-0
- https://doi.org/10.1016/S1875-5364(15)60014-0
- Author:
- Xiao-Wei LIU; Feng ZHANG; Shou-Hong GAO; Bo JIANG; Wan-Sheng CHEN
- Source:
- Chinese journal of natural medicines 2015 v.13 no.2 pp. 145-160
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; alkaloids; biochemical pathways; chemical composition; chromatography; cortex; databases; mechanism of action; metabolism; metabolites; oxidation; prototypes; rats; urine; xanthones
- Abstract:
- ... This study aimed to profile the chemical constituents of Zi-Shen pill (ZSP) and its metabolites in plasma, urine, and prostate tissue, after administration into rats. Based on the chromatographic retention behavior, fragmentation patterns of chemical components, published literatures, and literature databases, an UPLC-Q-TOF/MS (LC-TOF/MS) method was established to identify the components of ZSP an ...
- DOI:
- 10.1016/S1875-5364(15)60019-X
- https://doi.org/10.1016/S1875-5364(15)60019-X
- Author:
- Yang SHU; Mei CAO; Zhong-Qiong YIN; Ping LI; Tai-Qiang LI; Xing-Fa LONG; Lian-Fa ZHU; Ren-Yong JIA; Shu-Jun DAI; Jian ZHAO
- Source:
- Chinese journal of natural medicines 2015 v.13 no.2 pp. 119-126
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; adverse effects; animal ovaries; cortex; females; fetal death; histopathology; mice; pregnancy rate; reproductive toxicology; saponins; teratogenicity; toxicity testing; uterus
- Abstract:
- ... Saponin frsom Cortex Albiziae (SCA) are extensively used in the clinical treatment of tumor and depression. However, SCA may cause several adverse effects, including reproductive toxicity. The present study was designed to assess the mechanism by which SCA cause reproductive toxicity in female mice. The general reproductive toxicity testing was accomplished in female Kunming mice. The animals were ...
- DOI:
- 10.1016/S1875-5364(15)60015-2
- https://doi.org/10.1016/S1875-5364(15)60015-2