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You searched for: Journal name Chinese journal of natural medicines Remove constraint Journal name: Chinese journal of natural medicines Subject term antineoplastic activity Remove constraint Subject term: antineoplastic activity Text availability Citation in PubAg Remove constraint Text availability: Citation in PubAg
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1. Identification of multi-target anti-cancer agents from TCM formula by in silico prediction and in vitro validation

Author:
Bao-Yue ZHANG; Yi-Fu ZHENG; Jun ZHAO; De KANG; Zhe WANG; Lv-Jie XU; Ai-Lin LIU; Guan-Hua DU
Source:
Chinese journal of natural medicines 2022 v.20 no.5 pp. 332-351
ISSN:
1875-5364
Subject:
Bayesian theory; Oriental traditional medicine; algorithms; antineoplastic activity; chemical structure; computer simulation; databases; flavonoids; genes; prediction; terpenoids; therapeutics
Abstract:
... Cancer is a complex disease associated with multiple gene mutations and malignant phenotypes, and multi-target drugs provide a promising therapy idea for the treatment of cancer. Natural products with abundant chemical structure types and rich pharmacological characteristics could be ideal sources for screening multi-target antineoplastic drugs. In this paper, 50 tumor-related targets were collect ...
DOI:
10.1016/S1875-5364(22)60180-8

2. Influence of 6-shogaol potentiated on 5-fluorouracil treatment of liver cancer by promoting apoptosis and cell cycle arrest by regulating AKT/mTOR/MRP1 signalling

Author:
Yi ZHANG; Yong QU; Yun-Zhong CHEN
Source:
Chinese journal of natural medicines 2022 v.20 no.5 pp. 352-363
ISSN:
1875-5364
Subject:
P-glycoproteins; antineoplastic activity; apoptosis; cell cycle checkpoints; cell viability; flow cytometry; fluorouracil; immunohistochemistry; liver neoplasms; neoplasm cells; protein synthesis; toxicity testing
Abstract:
... Currently, chemoresistance seriously attenuates the curative outcome of liver cancer. The purpose of our work was to investigate the influence of 6-shogaol on the inhibition of 5-fluorouracil (5-FU) in liver cancer. The cell viability of cancer cells was determined by MTT assay. Liver cancer cell apoptosis and the cell cycle were examined utilizing flow cytometry. Moreover, qRT–PCR and western blo ...
DOI:
10.1016/S1875-5364(22)60174-2

3. Two cardenolide glycosides from the seed fairs of Asclepias curassavica and their cytotoxic activities

Author:
Ai-Jia JI; Qing MA; Mu-Yan KONG; Le-Yan LI; Xin-Lian CHEN; Zhong-Qiu LIU; Jin-Jun WU; Rong-Rong ZHANG
Source:
Chinese journal of natural medicines 2022 v.20 no.3 pp. 202-209
ISSN:
1875-5364
Subject:
Asclepias curassavica; acid hydrolysis; antineoplastic activity; colon; colorectal neoplasms; cytotoxicity; glycosides; humans; liver; liver neoplasms; lung neoplasms; lungs; spectral analysis; viability
Abstract:
... Two cardenolide glycosides, corotoxigenin 3-O-[β-D-glucopyranosyl-(1→4)-6-deoxy-β-D-glucopyranoside] (1) and coroglaucigenin 3-O-[β-D-glucopyranosyl-(1→4)-6-deoxy-β-D-glucopyranoside] (2), were isolated from the seed fairs of Asclepias curassavica. The structures of 1–2 were determined based on the combination of the analysis of their MS, NMR spectroscopic data and acid hydrolysis. The inhibitory ...
DOI:
10.1016/S1875-5364(21)60098-5

4. A four-component combination derived from Huang-Qin Decoction significantly enhances anticancer activity of irinotecan

Author:
Dou-Dou XU; Xiao-Ying HOU; Ou WANG; Di WANG; Dan-Ting LI; Si-Yuan QIN; Bo LV; Xiao-Min DAI; Zun-Jian ZHANG; Jian-Bo WAN; Feng-Guo XU
Source:
Chinese journal of natural medicines 2021 v.19 no.5 pp. 364-375
ISSN:
1875-5364
Subject:
Oriental traditional medicine; antineoplastic activity; apoptosis; baicalin; cancer therapy; cell movement; cell proliferation; diarrhea; gastrointestinal system; glycyrrhizin; macrophages; models; toxicity; toxicity testing; xenotransplantation
Abstract:
... Huang-Qin Decoction (HQD) is a classic prescription for diarrhea in Chinese medicine treatment. Recent studies have demonstrated that HQD and its modified formulation PHY906 could ameliorate irinotecan (CPT-11) induced gastrointestinal (GI) toxicity and enhance its anticancer therapeutic efficacy. Nevertheless, which constituents in HQD are effective is still unclear so far. The study aims to scre ...
DOI:
10.1016/S1875-5364(21)60034-1

5. Jiedu Sangen decoction inhibits chemoresistance to 5-fluorouracil of colorectal cancer cells by suppressing glycolysis via PI3K/AKT/HIF-1α signaling pathway

Author:
Lei-Tao SUN; Le-Yin ZHANG; Fei-Yu SHAN; Min-He SHEN; Shan-Ming RUAN
Source:
Chinese journal of natural medicines 2021 v.19 no.2 pp. 143-152
ISSN:
1875-5364
Subject:
antineoplastic activity; apoptosis; aspartic acid; bioinformatics; caspases; colorectal neoplasms; data collection; drug resistance; fluorouracil; glucose transporters; glycolysis; growth retardation; hexokinase; humans; hypoxia-inducible factor 1; lactate dehydrogenase; non-specific serine/threonine protein kinase; phosphatidylinositol 3-kinase; therapeutics
Abstract:
... Drug resistance is a major obstacle in the development of effective colorectal cancer (CRC) therapy. Our study aimed to explore the reversal abilities of Jiedu Sangen decoction (JSD) on the 5-fluorouracil (5-FU) resistance and its underlying molecular mechanisms. Expression changes in HIF-1 of CRC tissues were firstly revealed by bioinformatics analysis. Afterwards, cell viabilities of JSD and 5-F ...
DOI:
10.1016/S1875-5364(21)60015-8

6. Polyphyllin I promotes cell death via suppressing UPR-mediated CHOP ubiquitination and degradation in non-small cell lung cancer

Author:
Ming-Ming LIU; Miao-Lin ZHU; Rui-Fang DONG; Chao ZHANG; Hao ZHANG; Lei YANG; Ling-Yi KONG; Yuan-Zheng XIA
Source:
Chinese journal of natural medicines 2021 v.19 no.4 pp. 255-266
ISSN:
1875-5364
Subject:
antineoplastic activity; apoptosis; cell viability; cytotoxicity; databases; drug therapy; endoplasmic reticulum; flow cytometry; fluorescent antibody technique; gene overexpression; genes; gentian violet; herbal medicines; immunoblotting; lung neoplasms; membrane potential; mitochondrial membrane; plasmids; precipitin tests; prognosis; reactive oxygen species; statistics; transfection; ubiquitination; unfolded protein response
Abstract:
... Polyphyllin I (PPI) purified from Polyphyllarhizomes displays puissant cytotoxicity in many kinds of cancers. Several researches investigated its anti-cancer activity. But novel mechanisms are still worth investigation. This study aimed to explore PPI-induced endoplasmic reticulum (ER) stress as well as the underlying mechanism in non-small cell lung cancer (NSCLC). Cell viability or colony-formin ...
DOI:
10.1016/S1875-5364(21)60027-4

7. Recent progress on betulinic acid and its derivatives as antitumor agents: a mini review

Author:
Ye ZHONG; Nan LIANG; Yang LIU; Mao-Sheng CHENG
Source:
Chinese journal of natural medicines 2021 v.19 no.9 pp. 641-647
ISSN:
1875-5364
Subject:
antineoplastic activity; betulinic acid; bioavailability; water solubility
Abstract:
... Natural products are one of the important sources for the discovery of new drugs. Betulinic acid (BA), a pentacyclic triterpenoid widely distributed in the plant kingdom, exhibits powerful biological effects, including antitumor activity against various types of cancer cells. A considerable number of BA derivatives have been designed and prepared to remove their disadvantages, such as poor water s ...
DOI:
10.1016/S1875-5364(21)60097-3

8. Seed oil of Brucea javanica induces apoptosis through the PI3K/Akt signaling pathway in acute lymphocytic leukemia Jurkat cells

Author:
Hong ZHANG; Shi-Liang YIN; Li-Hui WANG; Li-Na JIA; Guang-Yue SU; Xiao-Qing LIU; Fan ZHOU; Peter BRESLIN; Ran MENG; Qi-Yi LI; Jing-Yu YANG; Chun-Fu WU
Source:
Chinese journal of natural medicines 2021 v.19 no.8 pp. 608-620
ISSN:
1875-5364
Subject:
Brucea javanica; antineoplastic activity; apoptosis; emulsions; genes; lymphocytic leukemia; mice; models; non-specific serine/threonine protein kinase; phosphatidylinositol 3-kinase; seed oils; China
Abstract:
... Brucea javanica oil emulsion (BJOE) has been used to treat tumor in China for more than 40 years. However, its components and effectiveness in the treatment of acute lymphocytic leukemia (ALL) and its mechanism of anti-cancer activity remain unknown. In the current study, high-performance liquid chromatography-evaporative light scattering detector (HPLC-ELSD) was used to analyze the components of ...
DOI:
10.1016/S1875-5364(21)60060-2

9. Studies on blood enrichment and anti-tumor effects of combined Danggui Buxue Decoction, Fe and rhEPO based on colon cancer-related anemia model and gut microbiota modulation

Author:
Xu-Qin SHI; Zhen-Hua ZHU; Shi-Jun YUE; Yu-Ping TANG; Yan-Yan CHEN; Zong-Jin PU; Hui-Juan TAO; Gui-Sheng ZHOU; Jin-Ao DUAN
Source:
Chinese journal of natural medicines 2021 v.19 no.6 pp. 422-431
ISSN:
1875-5364
Subject:
Helicobacter; Lachnospiraceae; Lactococcus; anemia; antineoplastic activity; blood; colon; colorectal neoplasms; inflammation; intestinal microorganisms; models; opportunistic pathogens; therapeutics
Abstract:
... Colon cancer-related anemia (CCRA) is mainly caused by systemic inflammation, intestinal bleeding, iron deficiency and chemotherapy-induced myelosuppression in colon cancer. However, the best therapeutic schedule and related mechanism on CCRA were still uncertain. Studies on blood enrichment and anti-tumor effects of combined Danggui Buxue Decoction (DBD), Fe and rhEPO based on CCRA and gut microb ...
DOI:
10.1016/S1875-5364(21)60041-9

10. Ziyuglycoside II inhibits the growth of digestive system cancer cells through multiple mechanisms

Author:
Ying ZHONG; Xiao-Yu LI; Fei ZHOU; Ya-Jie CAI; Rong SUN; Run-Ping LIU
Source:
Chinese journal of natural medicines 2021 v.19 no.5 pp. 351-363
ISSN:
1875-5364
Subject:
Sanguisorba officinalis; Western blotting; antineoplastic activity; apoptosis; cell cycle checkpoints; colon; drug therapy; esophageal neoplasms; fluorouracil; humans; ingredients; liver; liver neoplasms; mitochondria; morbidity; mortality; oxidative stress; pancreatic neoplasms; stomach neoplasms
Abstract:
... Digestive system cancers, including liver, gastric, colon, esophageal and pancreatic cancers, are the leading cause of cancers with high morbidity and mortality, and the question of their clinical treatment is still open. Previous studies have indicated that Ziyuglycoside II (ZYG II), the major bioactive ingredient extract from Sanguisorba officinalis L., significantly inhibits the growth of vario ...
DOI:
10.1016/S1875-5364(21)60033-X

11. cDNA cloning of a novel lectin that induce cell apoptosis from Artocarpus hypargyreus

Author:
Yu LUO; Lin-Jie ZENG; Xiao-Qin LIU; Lu LI; Qi-Yan ZENG
Source:
Chinese journal of natural medicines 2021 v.19 no.2 pp. 81-89
ISSN:
1875-5364
Subject:
Artocarpus; T-lymphocytes; amino acid sequences; antineoplastic activity; apoptosis; carbohydrates; caspase-3; cell membranes; cell proliferation; dose response; lectins; phosphatidylserines
Abstract:
... We isolated a novel lectin (AHL) from Artocarpus hypargyreusHance and showed its immunomodulatory activities. In this study, the amino acid sequence of AHL was determined by cDNA sequencing. AHL cDNA (875bp) contains a 456-bp open reading frame (ORF), which encodes a protein with 151 amino acids. AHL is a new member of jacalin-related lectin family (JRLs), which share high sequence similarities to ...
DOI:
10.1016/S1875-5364(21)60009-2

12. Antitumor activity of nervosine VII, and the crosstalk between apoptosis and autophagy in HCT116 human colorectal cancer cells

Author:
Shuai HUANG; Shuang-Mei ZHAO; Lian-Hai SHAN; Xian-Li ZHOU
Source:
Chinese journal of natural medicines 2020 v.18 no.2 pp. 81-89
ISSN:
1875-5364
Subject:
Oriental traditional medicine; antineoplastic activity; apoptosis; autophagy; caspase-9; colorectal neoplasms; human diseases; mitogen-activated protein kinase; neoplasm cells; proteins; pyrrolizidine alkaloids; signal transduction
Abstract:
... Nervosine VII is one of the known saturated pyrrolizidine alkaloids isolated from the plant of Liparis nervosa. This is first study to investigate the antitumor activity of nervosine VII in vitro, and the results indicated that nervosine VII induced autophagy and apoptosis in HCT116 human colorectal cancer cells. Mechanistic studies showed that nervosine VII-induced apoptosis was associated with t ...
DOI:
10.1016/S1875-5364(20)30009-1

13. Cordycepin inhibits pancreatic cancer cell growth in vitro and in vivo via targeting FGFR2 and blocking ERK signaling

Author:
Xue-Ying LI; Homng TAO; Can JIN; Zhen-Yun DU; Wen-Feng LIAO; Qing-Jiu TANG; Kan DING
Source:
Chinese journal of natural medicines 2020 v.18 no.5 pp. 345-355
ISSN:
1875-5364
Subject:
Cordyceps militaris; DNA damage; antineoplastic activity; apoptosis; caspase-3; caspase-9; cell cycle checkpoints; cell growth; cordycepin; cyclin-dependent kinase; cyclins; drug development; fibroblast growth factor receptor 2; neoplasm cells; pancreatic neoplasms; phosphorylation
Abstract:
... Cordycepin (3′-deoxyadenosine) from Cordyceps militaris has been reported to have anti-tumor effects. However, the molecular target and mechanism underlying cordycepin impeding pancreatic cancer cell growth in vitro and in vivo remain vague. In this study, we reported functional target molecule of cordycepin which inhibited pancreatic cancer cells growth in vitro and in vivo. Cordycepin was confir ...
DOI:
10.1016/S1875-5364(20)30041-8

14. Dracocephalum palmatum Stephan extract induces apoptosis in human prostate cancer cells via the caspase-8-mediated extrinsic pathway

Author:
Se-Eun LEE; Zhanna OKHLOPKOVA; Chiyeon LIM; Suin CHO
Source:
Chinese journal of natural medicines 2020 v.18 no.10 pp. 793-800
ISSN:
1875-5364
Subject:
B-cell lymphoma; Dracocephalum; Russia; Western blotting; adenosine diphosphate; antineoplastic activity; antioxidant activity; apoptosis; caspase-8; cell cycle checkpoints; cell lines; cell proliferation; drug therapy; ethyl acetate; flavonoids; humans; leaves; medicinal plants; neoplasm cells; nomadic people; prostatic neoplasms; reactive oxygen species; research; ribose; superoxide dismutase
Abstract:
... Dracocephalum palmatum Stephan is a medicinal plant traditionally used by nomadic people in Eastern Russia; however, research on this plant is currently limited. Recently, although studies have been conducted on the constituents of this plant and their antioxidant effects, data on its various pharmacological activities are still lacking. Thus, this study examined the anticancer potential of the dr ...
DOI:
10.1016/S1875-5364(20)60019-X

15. GL- V9 reverses adriamycin resistance in hepatocellular carcinoma cells by affecting JNK2-related autophagy

Author:
Yue YANG; Yan LIAO; Yan-Ping GUI; Li ZHAO; Lu-Bo GUO
Source:
Chinese journal of natural medicines 2020 v.18 no.7 pp. 491-499
ISSN:
1875-5364
Subject:
antineoplastic activity; autophagy; doxorubicin; drug resistance; flavonoids; hepatoma; neoplasm cells; patients
Abstract:
... Adriamycin resistance in HCC seriously hinders the treatment of patients, it is necessary to investigate the mechanisms. Autophagy is involved in adriamycin resistance and JNK2 is related to autophagy. However, whether JNK2 inducing drug resistance though autophagy is unknown. GL-V9, a new synthesized flavonoid derivative, has been proved of its anti-tumor effects. The aim of the study is to explo ...
DOI:
10.1016/S1875-5364(20)30059-5

16. In vitro antitumor effect of cucurbitacin E on human lung cancer cell line and its molecular mechanism

Author:
Si-Yuan JING; Zi-Dan WU; Tie-Hua ZHANG; Jie ZHANG; Zheng-Yi WEI
Source:
Chinese journal of natural medicines 2020 v.18 no.7 pp. 483-490
ISSN:
1875-5364
Subject:
antineoplastic activity; apoptosis; cell cycle checkpoints; cell lines; epidermal growth factor; humans; lung neoplasms; molecular dynamics; neoplasm cells; phosphorylation; pro-apoptotic proteins; protein kinases; signal transduction; transcription factors; tyrosine
Abstract:
... Cucurbitacin E (CuE) is previously reported to exhibit antitumor effect by several means. In this study, CuE acted as a tyrosine kinase inhibitor interfering with the epidermal growth factor receptor/mitogen-activated protein kinase (EGFR/MAPK) signaling pathway and subsequently induced apoptosis and cell cycle arrest in non-small-cell lung cancer (NSCLC) cell line A549. The apoptosis regulators, ...
DOI:
10.1016/S1875-5364(20)30058-3

17. Nagilactone E increases PD-L1 expression through activation of c-Jun in lung cancer cells

Author:
Yu-Chi CHEN; Mu-Yang HUANG; Le-Le ZHANG; Zhe-Ling FENG; Xiao-Ming JIANG; Luo-Wei YUAN; Run-Yue HUANG; Bo LIU; Hua YU; Yi-Tao WANG; Xiu-Ping CHEN; Li-Gen LIN; Jin-Jian LU
Source:
Chinese journal of natural medicines 2020 v.18 no.7 pp. 517-525
ISSN:
1875-5364
Subject:
Nageia nagi; antibodies; antineoplastic activity; cell membranes; humans; ligands; lung neoplasms; mitogen-activated protein kinase; neoplasm cells; phosphorylation; small interfering RNA
Abstract:
... Nagilactone E (NLE), a natural product with anticancer activities, is isolated from Podocarpus nagi. In this study, we reported that NLE increased programmed death ligand 1 (PD-L1) expressions at both protein and mRNA levels in human lung cancer cells, and enhanced its localization on the cell membrane. Mechanistically, NLE increased the phosphorylation and expression of c-Jun, and promoted the lo ...
DOI:
10.1016/S1875-5364(20)30062-5

18. The ethyl acetate extraction of Pileostegia tomentella (ZLTE) exerts anti-cancer effects on H1299 cells via ROS-induced canonical apoptosis

Author:
Qiu-Mei FAN; Wen-Tong ZHAO; Renyikun YUAN; Qin-Qin WANG; Li-Feng ZHANG; Hong-Wei GAO; Jing LENG; Shi-Lin YANG
Source:
Chinese journal of natural medicines 2020 v.18 no.7 pp. 508-516
ISSN:
1875-5364
Subject:
Ilex; Oriental traditional medicine; Tomentella; antineoplastic activity; apoptosis; butanol; death; ethyl acetate; extraction; herbal medicines; lactate dehydrogenase; lead; lung neoplasms; neoplasm cells; reactive oxygen species; viability
Abstract:
... Lung cancer is the leading cause of cancer death and the most common malignant tumor, the long-term survival of which has stagnated in the past several decades. Pileostegia tomentella Hand. Mazz is a traditional Chinese medicine called “Zhongliuteng” (ZLT) in the pharmacopeia, which has been proved to possess a potent anti-tumor effect on various cancers. In this study, the effects of ZLT N-butano ...
DOI:
10.1016/S1875-5364(20)30061-3

19. Anti-cancer activities of S-allylmercaptocysteine from aged garlic

Author:
Yi LV; Kwok-Fai SO; Nai-Kei WONG; Jia XIAO
Source:
Chinese journal of natural medicines 2019 v.17 no.1 pp. 43-49
ISSN:
1875-5364
Subject:
Oriental traditional medicine; antineoplastic activity; apoptosis; dietary supplements; disease control; garlic; models; neoplasms; organic sulfur compounds
Abstract:
... While most types of malignancies remain recalcitrant to treatment, application of natural products or their analogs in daily life has offered some hopes as an effective prophylaxis against cancer onset and progression in the past decades. Emerging evidence supports a link between garlic consumption and decreased cancer incidence. Notably, aged garlic extract (AGE) exhibits stronger anti-cancer act ...
DOI:
10.1016/S1875-5364(19)30008-1

20. Inhibitory effects of polyphyllins I and VII on human cisplatin-resistant NSCLC via p53 upregulation and CIP2A/AKT/mTOR signaling axis inhibition

Author:
Fei-Fei FENG; Peng CHENG; Chao SUN; Hui WANG; Wei WANG
Source:
Chinese journal of natural medicines 2019 v.17 no.10 pp. 768-777
ISSN:
1875-5364
Subject:
Oriental traditional medicine; Paris polyphylla; antineoplastic activity; apoptosis; autophagy; carcinogenesis; cell growth; cell proliferation; cisplatin; enzyme inhibitors; humans; lung neoplasms; oncogene proteins; phosphoprotein phosphatase
Abstract:
... Cancerous inhibitor of protein phosphatase 2A (CIP2A) is a human oncoprotein that is overexpressed in multiple kinds of cancers including non-small cell lung cancer (NSCLC). CIP2A plays an ‘oncogenic nexus’ to participate in the tumorigenesis and chemoresistance in several cancer types. AKT and mTORC1 overactivation are detected in NSCLC and many other cancers. Previous studies found that the CIP2 ...
DOI:
10.1016/S1875-5364(19)30093-7