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Chinese journal of natural medicines
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cell lines
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- Author:
- Ran XU; Hai-Qin XIE; Lu-Lu DENG; Jian-Xin ZHANG; Fu-Mei YANG; Jian-Hua LIU; Xiao-Jiang HAO; Yuan-Hu ZHANG
- Source:
- Chinese journal of natural medicines 2014 v.12 no.8 pp. 623-627
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; bufadienolides; cell lines; chromatography; cytotoxicity; inhibitory concentration 50; neoplasm cells; spectroscopy
- Abstract:
- ... To study the bufadienolides in the Chinese traditional drug “Ch'an Su” and their cytotoxic activity.Various chromatographic techniques were used to isolate the constituents, and their structures were elucidated through physical and spectroscopic data.Twenty compounds were isolated, and eighteen were evaluated in vitro for their cytotoxic activity against A-549 and K-562 cells.Compound 1 (bufalin 3 ...
- DOI:
- 10.1016/S1875-5364(14)60095-9
- https://doi.org/10.1016/S1875-5364(14)60095-9
- Author:
- Dan LIU; Wei QU; Ling ZHAO; Fu-Qin GUAN; Jing-Yu LIANG
- Source:
- Chinese journal of natural medicines 2014 v.12 no.2 pp. 139-141
- ISSN:
- 1875-5364
- Subject:
- Alpinia officinarum; Oriental traditional medicine; biochemical pathways; cell lines; chemical composition; chemical reactions; chromatography; cytotoxicity; humans; inhibitory concentration 50; rhizomes; spectral analysis
- Abstract:
- ... To study the chemical constituents of the rhizomes of Alpinia officinarum Hance.Compounds were isolated by repeated column chromatography, and their structures were elucidated on the basis of spectral analysis. The cytotoxic activities of these compounds were evaluated with the T98G and B16F10 cell lines by the MTT assay.A dimeric diarylheptanoid, named alpinin B (1), along with three known diaryl ...
- DOI:
- 10.1016/S1875-5364(14)60022-4
- https://doi.org/10.1016/S1875-5364(14)60022-4
- Author:
- Sofi Mubashir; Mohd Yousuf Dar; Bashir A. Lone; M. Iqbal Zargar; Wajaht A. Shah
- Source:
- Chinese journal of natural medicines 2014 v.12 no.8 pp. 567-572
- ISSN:
- 1875-5364
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; Caltha palustris; Oriental traditional medicine; anthelmintics; antimicrobial properties; antioxidant activity; antioxidants; cell lines; cervix; colon; cytotoxicity; fecal egg count; gastrointestinal nematodes; lethal concentration 50; leukemia; lungs; mortality; plant extracts; sheep; viability; India
- Abstract:
- ... The methanolic extract obtained from the root portion of Caltha palustris var. alba was evaluated for its anthelmintic efficacy against gastrointestinal nematodes of sheep under both in vitro and in vivo conditions using worm motility inhibition (WMI) assay and fecal egg count reduction (FECR) assay, respectively. The extract was subjected to antimicrobial activity using agar-well diffusion method ...
- DOI:
- 10.1016/S1875-5364(14)60087-X
- https://doi.org/10.1016/S1875-5364(14)60087-X
- Author:
- Zhi-Yao WANG; Wen-Jun HE; Wen-Bing ZHOU; Guang-Zhi ZENG; Zhi-Qi YIN; Shou-Xun ZHAO; Ning-Hua TAN
- Source:
- Chinese journal of natural medicines 2014 v.12 no.8 pp. 619-622
- ISSN:
- 1875-5364
- Subject:
- Candida albicans; Micromelum; Oriental traditional medicine; Staphylococcus; antimicrobial properties; bacteria; cell lines; chemical composition; cytotoxicity; fungi; high performance liquid chromatography; leaves; mass spectrometry; neoplasm cells; neoplasms; nuclear magnetic resonance spectroscopy; phenylpropanoids; scopoletin; silica gel; stems
- Abstract:
- ... To investigate the chemical and bioactive constituents from the stems and leaves of Micromelum integerrimum.The chemical constituents were isolated and purified by silica gel, Sephadex LH-20, and HPLC. Their structures were mainly elucidated on the basis of extensive 1D- and 2D-NMR spectroscopy and mass spectrometry. Their cytotoxicity and antimicrobial activities were tested by the SRB and turbid ...
- DOI:
- 10.1016/S1875-5364(14)60094-7
- https://doi.org/10.1016/S1875-5364(14)60094-7
- Author:
- Xue-Yan YANG; Yi-Fan ZHANG; Li-Jia LIU; Yi WANG; Ming-Ying SHANG; Feng XU; Guang-Xue LIU; Shao-Qing CAI
- Source:
- Chinese journal of natural medicines 2017 v.15 no.12 pp. 938-943
- ISSN:
- 1875-5364
- Subject:
- Linaceae; Oriental traditional medicine; aerial parts; anti-inflammatory activity; cell lines; cytotoxicity; diterpenoids; ethanol; ethyl acetate; inflammation; inhibitory concentration 50; lignans; macrophages; mice; models; nitric oxide; spectral analysis
- Abstract:
- ... A new lignan, tirpitzin A (17) together with 20 known compounds (1–16, and 18–21) were isolated from the ethyl acetate soluble fraction of ethanol extract of the aerial parts of Tirpitzia ovoidea. The structure of new compound was elucidated by means of spectroscopic analysis. Of the known compounds, 7–21 were isolated from Linaceae family for the first time. The pharmacological activity of the cr ...
- DOI:
- 10.1016/S1875-5364(18)30010-4
- https://doi.org/10.1016/S1875-5364(18)30010-4
- Author:
- Qiong ZHANG; Qing-Hong ZHENG; Yi-Shu SANG; Herman Ho-Yung SUNG; Zhi-Da MIN
- Source:
- Chinese journal of natural medicines 2018 v.16 no.12 pp. 946-950
- ISSN:
- 1875-5364
- Subject:
- Melia azedarach; Oriental traditional medicine; X-radiation; X-ray diffraction; bark; cell lines; cytotoxicity; limonoids; neoplasm cells; spectral analysis
- Abstract:
- ... Two new limonoids, 12-ethoxynimbolinins G and H (compounds 1 and 2), and one known compound, toosendanin (Chuanliansu) (compound 3), were isolated from the bark of Melia toosendan. Their structures were elucidated by spectroscopic analysis and X-ray techniques. The absolute configuration of toosendanin (3) was established by single-crystal X-ray diffraction. Compounds 1–3 were evaluated for their ...
- DOI:
- 10.1016/S1875-5364(18)30136-5
- https://doi.org/10.1016/S1875-5364(18)30136-5
- Author:
- Cheng-Yao MA; Jia-Hui LU; Xiang LI; Xiao LIU; Jian-Wei CHEN
- Source:
- Chinese journal of natural medicines 2019 v.17 no.4 pp. 291-297
- ISSN:
- 1875-5364
- Subject:
- Annona squamosa; Oriental traditional medicine; acetogenins; cell lines; cytotoxicity; multiple drug resistance; seeds; spectral analysis
- Abstract:
- ... Eight new annonaceous acetogenins, squamotin A-D (1–4), annosquatin IV-V (5 and 6), muricin O (7) and squamosten B (8), together with four known ones (9–12) were isolated from the seeds of Annona squamosa. Their structures were elucidated by chemical methods and spectral data. The inhibitory activities of compound 1–9 against three multidrug resistance cell lines were evaluated. All tested compoun ...
- DOI:
- 10.1016/S1875-5364(19)30032-9
- https://doi.org/10.1016/S1875-5364(19)30032-9
- Author:
- Zheng LI; Qian-Qian CHEN; Christopher Wai Kei LAM; Jian-Ru GUO; Wei-Jia ZHANG; Cai-Yun WANG; Vincent Kam Wai WONG; Mei-Cun YAO; Wei ZHANG
- Source:
- Chinese journal of natural medicines 2019 v.17 no.8 pp. 608-615
- ISSN:
- 1875-5364
- Subject:
- DNA replication; Oriental traditional medicine; adenocarcinoma; antineoplastic activity; cell cycle checkpoints; cell lines; cytotoxicity; epithelial cells; humans; hydroxyurea; interphase; liquid chromatography; lungs; mass spectrometry; metabolism; metabolomics; nucleosides; resveratrol
- Abstract:
- ... In an effort to understand the molecular events contributing to the cytotoxicity activity of resveratrol (RSV), we investigated its effects on human lung adenocarcinoma epithelial cell line A549 at different concentrations. Cellular nucleoside metabolic profiling was determined by an established liquid chromatography-mass spectrometry method in A549 cells. RSV resulted in significant decreases and ...
- DOI:
- 10.1016/S1875-5364(19)30063-9
- https://doi.org/10.1016/S1875-5364(19)30063-9
- Author:
- Peng-Cheng LIN; Lin-Lin JI; Xiang-Jian ZHONG; Jin-Jie LI; Xin WANG; Xiao-Ya SHANG; Sheng LIN
- Source:
- Chinese journal of natural medicines 2019 v.17 no.1 pp. 22-26
- ISSN:
- 1875-5364
- Subject:
- Cirsium arvense; Oriental traditional medicine; animal ovaries; antineoplastic activity; cell lines; chemical structure; colorectal neoplasms; cytotoxicity; food plants; humans; inhibitory concentration 50; ovarian neoplasms; secretion; spectral analysis; triterpenoids; tumor necrosis factor-alpha
- Abstract:
- ... Guided by TNF-α secretion inhibitory activity assay, four taraxastane-type triterpenoids, including two new ones, 22-oxo-20-taraxasten-3β, 30-diol (1) and 22α-hydroxy-20-taraxasten-30β, 30-triol (2), have been obtained from an active fraction of the petroleum ether-soluble extract of the the medicinal and edible plant Cirsium setosum. Their structures were elucidated by spectroscopic data and CD d ...
- DOI:
- 10.1016/S1875-5364(19)30005-6
- https://doi.org/10.1016/S1875-5364(19)30005-6
- Author:
- Xiao-Hui CHEN; Guo-Liang ZHOU; Chun-Xiao SUN; Xiao-min ZHANG; Guo-Jian ZHANG; Tian-Jiao ZHU; Jing LI; Qian CHE; De-Hai LI
- Source:
- Chinese journal of natural medicines 2020 v.18 no.11 pp. 850-854
- ISSN:
- 1875-5364
- Subject:
- Penicillium; cell lines; cytotoxicity; fungi; marine sediments; South China Sea
- Abstract:
- ... Three new mycophenolic acid derivatives, penicacids E–G (1–3), together with three known analogues, mycophenolic acid (4), 4′-hydroxy-mycophenolic acid (5) and mycophenolic methyl ester (6), were isolated from a marine-derived fungus Penicillium parvum HDN17-478 from a South China Sea marine sediment sample. The structures of compounds 1–3 were elucidated by HRMS, NMR, and Mosher's method. Among t ...
- DOI:
- 10.1016/S1875-5364(20)60027-9
- https://doi.org/10.1016/S1875-5364(20)60027-9
- Author:
- Hui-Bo LIU; Zhao-Ming LIU; Yu-Chan CHEN; Hai-Bo Tan; Sai-Ni LI; Dong-Li LI; Hong-Xin LIU; Wei-Min ZHANG
- Source:
- Chinese journal of natural medicines 2021 v.19 no.11 pp. 874-880
- ISSN:
- 1875-5364
- Subject:
- Diaporthe; Lithocarpus; X-ray diffraction; cell lines; cytotoxicity; fungi; neoplasm cells; spectral analysis
- Abstract:
- ... Nine new compounds, including five natural rarely-occurring 2, 3-dihydro-1H-indene derivatives named diaporindenes E–I (1–5), and four new benzophenone analogues named tenellones J–M (6–9) were isolated from the deep-sea sediment-derived fungus Phomopsis lithocarpus FS508. All the structures for these new compounds were fully characterized on the basis of spectroscopic data, NMR spectra, and ECD c ...
- DOI:
- 10.1016/S1875-5364(21)60095-X
- https://doi.org/10.1016/S1875-5364(21)60095-X