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You searched for: Journal name Chinese journal of natural medicines Remove constraint Journal name: Chinese journal of natural medicines Subject term cell lines Remove constraint Subject term: cell lines Subject term humans Remove constraint Subject term: humans
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1. Dracocephalum palmatum Stephan extract induces apoptosis in human prostate cancer cells via the caspase-8-mediated extrinsic pathway

Author:
Se-Eun LEE; Zhanna OKHLOPKOVA; Chiyeon LIM; Suin CHO
Source:
Chinese journal of natural medicines 2020 v.18 no.10 pp. 793-800
ISSN:
1875-5364
Subject:
B-cell lymphoma; Dracocephalum; Russia; Western blotting; adenosine diphosphate; antineoplastic activity; antioxidant activity; apoptosis; caspase-8; cell cycle checkpoints; cell lines; cell proliferation; drug therapy; ethyl acetate; flavonoids; humans; leaves; medicinal plants; neoplasm cells; nomadic people; prostatic neoplasms; reactive oxygen species; research; ribose; superoxide dismutase
Abstract:
... Dracocephalum palmatum Stephan is a medicinal plant traditionally used by nomadic people in Eastern Russia; however, research on this plant is currently limited. Recently, although studies have been conducted on the constituents of this plant and their antioxidant effects, data on its various pharmacological activities are still lacking. Thus, this study examined the anticancer potential of the dr ...
DOI:
10.1016/S1875-5364(20)60019-X

2. In vitro antitumor effect of cucurbitacin E on human lung cancer cell line and its molecular mechanism

Author:
Si-Yuan JING; Zi-Dan WU; Tie-Hua ZHANG; Jie ZHANG; Zheng-Yi WEI
Source:
Chinese journal of natural medicines 2020 v.18 no.7 pp. 483-490
ISSN:
1875-5364
Subject:
antineoplastic activity; apoptosis; cell cycle checkpoints; cell lines; epidermal growth factor; humans; lung neoplasms; molecular dynamics; neoplasm cells; phosphorylation; pro-apoptotic proteins; protein kinases; signal transduction; transcription factors; tyrosine
Abstract:
... Cucurbitacin E (CuE) is previously reported to exhibit antitumor effect by several means. In this study, CuE acted as a tyrosine kinase inhibitor interfering with the epidermal growth factor receptor/mitogen-activated protein kinase (EGFR/MAPK) signaling pathway and subsequently induced apoptosis and cell cycle arrest in non-small-cell lung cancer (NSCLC) cell line A549. The apoptosis regulators, ...
DOI:
10.1016/S1875-5364(20)30058-3

3. Investigation into perturbed nucleoside metabolism and cell cycle for elucidating the cytotoxicity effect of resveratrol on human lung adenocarcinoma epithelial cells

Author:
Zheng LI; Qian-Qian CHEN; Christopher Wai Kei LAM; Jian-Ru GUO; Wei-Jia ZHANG; Cai-Yun WANG; Vincent Kam Wai WONG; Mei-Cun YAO; Wei ZHANG
Source:
Chinese journal of natural medicines 2019 v.17 no.8 pp. 608-615
ISSN:
1875-5364
Subject:
DNA replication; Oriental traditional medicine; adenocarcinoma; antineoplastic activity; cell cycle checkpoints; cell lines; cytotoxicity; epithelial cells; humans; hydroxyurea; interphase; liquid chromatography; lungs; mass spectrometry; metabolism; metabolomics; nucleosides; resveratrol
Abstract:
... In an effort to understand the molecular events contributing to the cytotoxicity activity of resveratrol (RSV), we investigated its effects on human lung adenocarcinoma epithelial cell line A549 at different concentrations. Cellular nucleoside metabolic profiling was determined by an established liquid chromatography-mass spectrometry method in A549 cells. RSV resulted in significant decreases and ...
DOI:
10.1016/S1875-5364(19)30063-9

4. Taraxastane-type triterpenoids from the medicinal and edible plant Cirsium setosum

Author:
Peng-Cheng LIN; Lin-Lin JI; Xiang-Jian ZHONG; Jin-Jie LI; Xin WANG; Xiao-Ya SHANG; Sheng LIN
Source:
Chinese journal of natural medicines 2019 v.17 no.1 pp. 22-26
ISSN:
1875-5364
Subject:
Cirsium arvense; Oriental traditional medicine; animal ovaries; antineoplastic activity; cell lines; chemical structure; colorectal neoplasms; cytotoxicity; food plants; humans; inhibitory concentration 50; ovarian neoplasms; secretion; spectral analysis; triterpenoids; tumor necrosis factor-alpha
Abstract:
... Guided by TNF-α secretion inhibitory activity assay, four taraxastane-type triterpenoids, including two new ones, 22-oxo-20-taraxasten-3β, 30-diol (1) and 22α-hydroxy-20-taraxasten-30β, 30-triol (2), have been obtained from an active fraction of the petroleum ether-soluble extract of the the medicinal and edible plant Cirsium setosum. Their structures were elucidated by spectroscopic data and CD d ...
DOI:
10.1016/S1875-5364(19)30005-6

5. The Zuo Jin Wan Formula increases chemosensitivity of human primary gastric cancer cells by AKT mediated mitochondrial translocation of cofilin-1

Author:
Meng-Yao SUN; Dan-Dan WANG; Jian SUN; Xiao-Hua ZHAO; Si CAI; Qiu-Xue WU; Tao JIE; Zhen-Hua NI; Jian-Yue SUN; Qing-Feng TANG
Source:
Chinese journal of natural medicines 2019 v.17 no.3 pp. 198-208
ISSN:
1875-5364
Subject:
Oriental traditional medicine; Western blotting; apoptosis; cell lines; cell proliferation; cisplatin; drug therapy; flow cytometry; humans; mitochondria; models; neoplasm cells; patients; protein synthesis; staining; stomach neoplasms
Abstract:
... Resistance to cisplatin (DDP)-based chemotherapy is a major cause of treatment failure in human gastric cancer (GC). It is necessary to identify the drugs to re-sensitize GC cells to DDP. In our previous research, Zuo Jin Wan Formula (ZJW) has been proved could increase the mitochondrial apoptosis via cofilin-1 in a immortalized cell line, SGC-7901/DDP. Due to the immortalized cells may still diff ...
DOI:
10.1016/S1875-5364(19)30022-6

6. Polyphenols isolated from Acacia mearnsii bark with anti-inflammatory and carbolytic enzyme inhibitory activities

Author:
Jia XIONG; Mary H GRACE; Debora ESPOSITO; Slavko KOMARNYTSKY; Fei WANG; Mary Ann LILA
Source:
Chinese journal of natural medicines 2017 v.15 no.11 pp. 816-824
ISSN:
1875-5364
Subject:
Acacia mearnsii; Oriental traditional medicine; acarbose; alpha-amylase; alpha-glucosidase; anti-inflammatory activity; bark; cell lines; countercurrent chromatography; digestion; enzyme activity; enzyme inhibition; genes; humans; inducible nitric oxide synthase; inflammation; inhibitory concentration 50; interleukin-1beta; lipopolysaccharides; macrophages; mice; nitric oxide; proanthocyanidins; reactive oxygen species
Abstract:
... The present study was designed to characterize the polyphenols isolated from Acacia mearnsii bark crude extract (B) and fractions (B1-B7) obtained by high-speed counter-current chromatography (HSCCC) and evaluate their anti-inflammatory and carbolytic enzymes (α-glucosidase and α-amylase) inhibitory activities. Fractions B4, B5, B6, B7 (total phenolics 850.3, 983.0, 843.9, and 572.5 mg·g⁻¹, respec ...
DOI:
10.1016/S1875-5364(18)30015-3

7. In silico target fishing for the potential bioactive components contained in Huanglian Jiedu Tang (HLJDD) and elucidating molecular mechanisms for the treatment of sepsis

Author:
Shi-Tang MA; Cheng-Tao FENG; Guo-Liang DAI; Yue SONG; Guo-Liang ZHOU; Xiao-Lin ZHANG; Cheng-Gui MIAO; Hao YU; Wen-Zheng JU
Source:
Chinese journal of natural medicines 2015 v.13 no.1 pp. 30-40
ISSN:
1875-5364
Subject:
Oriental traditional medicine; berberine; bioactive compounds; bioinformatics; cell lines; databases; fish; humans; mechanism of action; models; neoplasm cells; proteins; screening; sepsis (infection)
Abstract:
... The present study was designed to target fish for potential bioactive components contained in a Huang Lian Jie Du decoction (HLJDD) and identify the underlying mechanisms of action for the treatment of sepsis at the molecular level. he bioactive components database of HLJDD was constructed and the sepsis-associated targets were comprehensively investigated. The 3D structures of the PAFR and TXA2R ...
DOI:
10.1016/S1875-5364(15)60004-8

8. A new dimeric diarylheptanoid from the rhizomes of Alpinia officinarum

Author:
Dan LIU; Wei QU; Ling ZHAO; Fu-Qin GUAN; Jing-Yu LIANG
Source:
Chinese journal of natural medicines 2014 v.12 no.2 pp. 139-141
ISSN:
1875-5364
Subject:
Alpinia officinarum; Oriental traditional medicine; biochemical pathways; cell lines; chemical composition; chemical reactions; chromatography; cytotoxicity; humans; inhibitory concentration 50; rhizomes; spectral analysis
Abstract:
... To study the chemical constituents of the rhizomes of Alpinia officinarum Hance.Compounds were isolated by repeated column chromatography, and their structures were elucidated on the basis of spectral analysis. The cytotoxic activities of these compounds were evaluated with the T98G and B16F10 cell lines by the MTT assay.A dimeric diarylheptanoid, named alpinin B (1), along with three known diaryl ...
DOI:
10.1016/S1875-5364(14)60022-4

9. Anticancer and multidrug-resistance reversing potential of traditional medicinal plants and their bioactive compounds in leukemia cell lines

Author:
Ravichandran Senthilkumar; Bao-An CHEN; Xiao-Hui CAI; Rong FU
Source:
Chinese journal of natural medicines 2014 v.12 no.12 pp. 881-894
ISSN:
1875-5364
Subject:
Oriental traditional medicine; antineoplastic agents; bioactive compounds; cell lines; humans; leukemia; medicinal plants; multiple drug resistance; neoplasm cells; patients; survival rate; therapeutics
Abstract:
... Multidrug resistance remains a serious clinical problem in the successful therapy of malignant diseases. It occurs in cultured tumor cell lines, as well as in human cancers. Therefore, it is critical to develop novel anticancer drugs with multidrug-resistance modulating potential to increase the survival rate of leukemia patients. Plant-derived natural products have been used for the treatment of ...
DOI:
10.1016/S1875-5364(14)60131-X

10. Oral JS-38, a metabolite from Xenorhabdus sp., has both anti-tumor activity and the ability to elevate peripheral neutrophils

Author:
Min-Yu LIU; Lin XIAO; Geng-Hui CHEN; Yong-Xiang WANG; Wei-Xia XIONG; Fei LI; Ying LIU; Xiao-Ling HUANG; Yi-Fang DENG; Zhen ZHANG; Hai-Yan SUN; Quan-Hai LIU; Ming YIN
Source:
Chinese journal of natural medicines 2014 v.12 no.10 pp. 768-776
ISSN:
1875-5364
Subject:
Oriental traditional medicine; Xenorhabdus; allografting; animal models; antineoplastic activity; apoptosis; body weight; cell lines; cyclophosphamide; fluorouracil; granulocyte colony-stimulating factor; hepatoma; humans; inhibitory concentration 50; lung neoplasms; metabolites; mice; neoplasm cells; neutropenia; neutrophils; sarcoma
Abstract:
... JS-38 (mitothiolore), a synthetic version of a metabolite isolated from Xenorhabdus sp., was evaluated for its anti-tumor and white blood cell (WBC) elevating activities.These anti-proliferative activities were assessed in vitro using a panel of ten cell lines. The anti-tumor activities were tested in vivo using B16 allograft mouse models and xenograft models of A549 human lung carcinoma and QGY h ...
DOI:
10.1016/S1875-5364(14)60117-5