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You searched for: Journal name Chinese journal of natural medicines Remove constraint Journal name: Chinese journal of natural medicines
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1. 17-[16,17-Dihydroxycyclooctatinyl]-hexaketide ester from Streptomyces sp. SR107

Author:
Meng-Yu-Jie LIU; Shan-Ren LI; LU Chun-Hua
Source:
Chinese journal of natural medicines 2016 v.14 no.12 pp. 931-933
ISSN:
1875-5364
Subject:
Oriental traditional medicine; Streptomyces; antibacterial properties; diterpenoids; esterification; nuclear magnetic resonance spectroscopy; spectral analysis
Abstract:
... A new hexaketide acid esterified by the 17-hydroxyl group of 16,17-dihydroxycyclooctatin, namely 17-[16,17-dihydroxycyclooctatinyl]-hexaketide ester (1), a member of the group of rare bacterial diterpenes with a fused 5-8-5 ring system was isolated from strain Streptomyces sp. SR107. The structure was determined on the basis of its spectral data (¹H NMR, ¹³C NMR, ¹H-¹H COSY, HSQC, HMBC, NOESY, IR ...
DOI:
10.1016/S1875-5364(17)30018-3

2. 1H NMR-based metabolomics approach to investigating the renal protective effects of Genipin in diabetic rats

Author:
Jun-Sheng TIAN; Lei ZHAO; Xiao-Li SHEN; Huan LIU; Xue-Mei QIN
Source:
Chinese journal of natural medicines 2018 v.16 no.4 pp. 261-270
ISSN:
1875-5364
Subject:
Oriental traditional medicine; amino acid metabolism; animal disease models; biochemical pathways; cytotoxicity; diabetic nephropathy; energy metabolism; glycemic effect; ketone bodies; kidneys; metabolomics; methylamine; nuclear magnetic resonance spectroscopy; patients; protective effect; rats; renal function; serine; threonine; urinalysis
Abstract:
... Diabetic nephropathy is one of the various complications of diabetes mellitus, affecting patients for lifetime. Earlier studies have revealed that genipin can not only improve diabetes, but also induce cytotoxicity. Therefore, it is not clear which effect of genipin on kidneys occurs, when it is used in the treatment of diabetes. In the present study, we performed nuclear magnetic resonance (NMR)- ...
DOI:
10.1016/S1875-5364(18)30056-6

3. 3, 4-seco-Isopimarane and 3, 4-seco-pimarane diterpenoids from Callicarpa nudiflora

Author:
Hang HUANG; Chun-Ping TANG; Chang-Qiang KE; Ren-Geng SHU; Yang YE
Source:
Chinese journal of natural medicines 2021 v.19 no.8 pp. 632-640
ISSN:
1875-5364
Subject:
Callicarpa nudiflora; circular dichroism spectroscopy; density functional theory; diterpenoids; medicinal plants; phytochemicals; spectral analysis
Abstract:
... A phytochemical investigation was carried out on the extract of a medicinal plant Callicarpa nudiflora, resulting in the characterization of five new 3, 4-seco-isopimarane (1–5) and one new 3, 4-seco-pimarane diterpenoid (6), together with four known compounds. The structures of the new compounds were fully elucidated by extensive analysis of MS, 1D and 2D NMR spectroscopic data, and time-dependen ...
DOI:
10.1016/S1875-5364(21)60063-8

4. 3, 4-seco-Labdane diterpenoids from the leaves of Callicarpa nudiflora with anti-inflammatory effects

Author:
Hong-Gang WANG; Fu-Kang LUO; Xiang LEI; Yun-Da YAO; Guo-Chao LIAO; Zhong-Qiu LIU; Zhi-Hong JIANG; Hua ZHOU; Peng WU
Source:
Chinese journal of natural medicines 2019 v.17 no.9 pp. 707-712
ISSN:
1875-5364
Subject:
Callicarpa nudiflora; Oriental traditional medicine; anti-inflammatory activity; dexamethasone; diterpenoids; leaves; nitric oxide; spectral analysis
Abstract:
... Four new 3, 4-seco-labdane diterpenoids, nudiflopenes J-M, were isolated from the leaves of Callicarpa nudiflora along with six known compounds. The structures of these diterpenoids were determined by comprehensive spectroscopic analysis. All the isolated compounds were evaluated for their inhibitory effects on NO production in LPS-stimulated RPMs and RAW264.7 cells. The results suggest that nudif ...
DOI:
10.1016/S1875-5364(19)30085-8

5. 3′-Methoxydaidzein exerts analgesic activity by inhibiting voltage-gated sodium channels

Author:
Run-Jia XU; Shuo-Han FEI; Lin-Yan CHEN; Gan WANG; Ming LIU; Wen-Sheng ZHANG; Xiu-Wen YAN; Ren LAI; Chuan-Bin SHEN
Source:
Chinese journal of natural medicines 2019 v.17 no.6 pp. 413-423
ISSN:
1875-5364
Subject:
Oriental traditional medicine; analgesia; analgesic effect; daidzein; dietary supplements; drugs; genistein; heat; hypersensitivity; inhibitory concentration 50; mice; neurons; pain; sodium channels; soybean products
Abstract:
... Isoflavones are widely consumed by people around the world in the form of soy products, dietary supplements and drugs. Many isoflavones or related crude extracts have been reported to exert pain-relief activities, but the mechanism remains unclear. Voltage-gated sodium channels (VGSCs) play important roles in excitability of pain sensing neurons and many of them are important nociceptors. Here, we ...
DOI:
10.1016/S1875-5364(19)30049-4

6. 5, 6-Dihydropyranobenzopyrone: a previously undetermined antioxidant isolated from Polygonum amplexicaule

Author:
Mudasir A. Tantry; Mohamed M. Radwan; Seema Akbar; Ikhlas A. Khan
Source:
Chinese journal of natural medicines 2012 v.10 no.1 pp. 28-31
ISSN:
1875-5364
Subject:
gallic acid; chemical composition; rutin; fractionation; nuclear magnetic resonance spectroscopy; caffeic acid; glucose; Bistorta amplexicaulis; chromatography; antioxidant activity; chlorogenic acid; catechin; antioxidants
Abstract:
... AIM: To study the chemical constituents and their bioactivity of Polygonum amplexicaule. METHODS: The isolation of compounds was achieved by chromatographic techniques and structure of the isolates was established by UV, IR, HRESI-MS and NMR including 1D and 2D experiments. RESULTS: Bioassay-guided fractionation of an ethanolic extract of Polygonum amplexicaule led to the isolation of a hitherto u ...
DOI:
10.1016/S1875-5364(12)60006-5
PubMed:
23302526

7. 5, 7, 2’, 4’, 5’-Pentamethoxyflavanone regulates M1/M2 macrophage phenotype and protects the septic mice

Author:
Li-Li FENG; Li-Sha XU; Meng-Meng GUO; Wei HUANG; Jia-Zhen ZHU; Ling-Dong KONG; Xu-Dong WU; Qiang XU
Source:
Chinese journal of natural medicines 2019 v.17 no.5 pp. 363-371
ISSN:
1875-5364
Subject:
Oriental traditional medicine; anti-inflammatory activity; flavonoids; gene expression regulation; in vivo studies; inducible nitric oxide synthase; interleukin-1beta; interleukin-6; lungs; macrophages; messenger RNA; mice; phenotype; protective effect; protein content; sepsis (infection); signal transduction; survival rate; toxicity; transcription factors; tumor necrosis factor-alpha
Abstract:
... Flavonoids have been reported to exert protective effect against many inflammatory diseases, while the underlying cellular mechanisms are still not completely known. In the present study, we explored the anti-inflammation activity of 5, 7, 2’, 4’, 5’-pentamethoxyflavanone (abbreviated as Pen.), a kind of polymethoxylated flavonoid, both in vitro and in vivo experiments. Pen. was showed no obvious ...
DOI:
10.1016/S1875-5364(19)30042-1

8. 5-Hydroxymethylfurfural protects against ER stress-induced apoptosis in GalN/TNF-α-injured L02 hepatocytes through regulating the PERK-eIF2α signaling pathway

Author:
Ze-Qun JIANG; Yan-Xia MA; Mu-Han LI; Xiu-Qin ZHAN; Xu ZHANG; Ming-Yan WANG
Source:
Chinese journal of natural medicines 2015 v.13 no.12 pp. 896-905
ISSN:
1875-5364
Subject:
Oriental traditional medicine; RNA; Western blotting; apoptosis; calcium; dose response; flow cytometry; fluorescent antibody technique; hepatocytes; humans; hydroxymethylfurfural; liver diseases; mechanism of action; phosphorylation; protective effect; protein kinases; proteins; signal transduction; therapeutics; tumor necrosis factor-alpha; viability; water solubility
Abstract:
... 5-Hydroxymethylfurfural (5-HMF), a water-soluble compound extracted from wine-processed Fructus corni, is a novel hepatic protectant for treating acute liver injury. The present study was designed to investigate the protective effect of 5-HMF in human L02 hepatocytes injured by D-galactosamine (GalN) and tumor necrosis factor-α (TNF-α) in vitro and to explore the underlying mechanisms of action. O ...
DOI:
10.1016/S1875-5364(15)30095-9

9. A 75 kDa glycoprotein isolated from Cudrania tricuspidata Bureau induces colonic epithelial proliferation and ameliorates mouse colitis induced by dextran sulfate sodium

Author:
Jeong-Bae Park; Do-Wan Kim; Kye-Taek Lim; Sejong Oh; Sei-Jung Lee
Source:
Chinese journal of natural medicines 2021 v.19 no.1 pp. 46-55
ISSN:
1875-5364
Subject:
Maclura tricuspidata; body weight; cell proliferation; colitis; colon; cyclin-dependent kinase; cyclins; dextran sulfate; diarrhea; epithelium; glycoproteins; humans; mice; mitogen-activated protein kinase; phosphorylation; protein kinase C
Abstract:
... Cudrania tricuspidata Bureau (CTB), a species of the Moraceae plant, has been used as a bruise recovery treatment. This study aimed to determine whether the 75 kDa phytoglycoprotein extracted from CTB has a regulatory effect on the proliferation of human colon epithelial cells and the pathological process of inflammatory bowel disease (IBD). We found that CTB glycoprotein significantly induces the ...
DOI:
10.1016/S1875-5364(21)60005-5

10. A Chromatographic Study on the Glycosides of Aerva lanata L.

Author:
Yamunadevi M; Wesely EG; Johnson M
Source:
Chinese journal of natural medicines 2011 v.9 no.3 pp. 210-214
ISSN:
1875-5364
Subject:
Aerva; bioactive properties; chromatography; flowers; glycosides; leaves; new drugs; screening; seeds; India
Abstract:
... AIM: In order to identify the HPTLC profile (bio-marker), at species level, for the identification and confirmation of crude drugs, HPTLC separation was initiated on different parts of Aerva lanata L. from South India. METHODS: Preliminary phytochemical screening was done by the method of Harborne. HPTLC studies were carried out following Harborne and Wagner et al method. The Ethyl acetate-ethanol ...
DOI:
10.3724/SP.J.1009.2011.00210

11. A LC-ESI-MS method for the simultaneous determination of madecassoside and its metabolite madecassic acid in rat plasma: comparison pharmacokinetics in normal and collagen-induced arthritic rats

Author:
Ting WANG; Dan-Dan LENG; Fei-Fei GAO; Chun-Jie JIANG; Yu-Feng XIA; Yue DAI
Source:
Chinese journal of natural medicines 2014 v.12 no.12 pp. 943-951
ISSN:
1875-5364
Subject:
Oriental traditional medicine; acetonitrile; arthritis; electrospray ionization mass spectrometry; formic acid; high performance liquid chromatography; ionization; metabolites; monitoring; oral administration; pharmacokinetics; rats; regression analysis
Abstract:
... To develop a simple and highly sensitive high performance liquid chromatography with electrospray ionization mass spectrometric (LC-ESI-MS) method for the simultaneous determination of madecassoside and its major metabolite madecassic acid in rat plasma, and compare the pharmacokinetics of the two compounds in normal and collagen-induced arthritis (CIA) rats. Glycyrrhetinic acid was used as the in ...
DOI:
10.1016/S1875-5364(14)60138-2

12. A New Biphenyl from the Fermentation Broth of Plant Endophytic Fungus Pestalotiopsis zonata isolated from Cyrtotachys lakka

Author:
Xiao-Long YANG; Su ZHANG; Shao-Jun SONG; Yan ZHANG; Du-Qiang LUO; Meng ZHANG
Source:
Chinese journal of natural medicines 2011 v.9 no.2 pp. 101-104
ISSN:
1875-5364
Subject:
Acinetobacter baumannii; Enterococcus faecium; Escherichia coli; Klebsiella pneumoniae; Pestalotiopsis; Pseudomonas aeruginosa; Staphylococcus aureus; antibacterial properties; bacteria; biphenyl; chemical composition; culture media; endophytes; fungi; gel chromatography; inhibitory concentration 50; methicillin; silica gel; spectroscopy; China
Abstract:
... AIM: To investigate the chemical constituents of the fermentation broth of the plant endophytic fungus Pestalotiopsis zonata isolated from Cyrtotachys lakka in Hainan, China. METHOD: Compounds 1–4 were separated and purified by silica gel chromatography and Sephadex LH-20. Their structures were elucidated by extensive spectroscopic analysis. Compound 1 was tested for its antibacterial activity aga ...
DOI:
10.3724/SP.J.1009.2011.00101

13. A New Diphenylmethane Derivative from Uvaria kurizz with Cardiovascular Activity

Author:
Zi-Ming LU; Qing-Jian ZHANG; Ruo-Yun CHEN; De-Quan YU
Source:
Chinese journal of natural medicines 2011 v.9 no.2 pp. 90-93
ISSN:
1875-5364
Subject:
Uvaria; blood flow; chemical composition; chromatography; diterpenoids; heart failure; methane; models; ouabain; rats; silica gel; spectroscopy
Abstract:
... AIM: To study the chemical constituents of Uvaria kurzii (King) P. T. (Annonaceae). METHOD: The chemical constituents were isolated with silica gel and Sephadex LH-20 column chromatography and their structures were elucidated by spectroscopic and synthetic methods. RESULTS: A diphenylmethane derivative (1) together with 5 known ent-kaurane diterpenoids (2–6) were isolated and identified as bis (4- ...
DOI:
10.3724/SP.J.1009.2011.00090

14. A New Phragmalin-type Limonoid from Chukrasia tabularis var. velutina

Author:
Jun LUO; Jun-Song WANG; Wen-Jun CAO; Ling-Yi KONG
Source:
Chinese journal of natural medicines 2011 v.9 no.2 pp. 98-100
ISSN:
1875-5364
Subject:
high performance liquid chromatography; limonoids; nuclear magnetic resonance spectroscopy; silica gel; spectral analysis
Abstract:
... AIM: To study the limonoid constituents of Chukrasia tabularis var. velutina. METHODS: The constituents were isolated with silica gel, ODS column chromatography and preparative HPLC, their structures were elucidated on the basis of the NMR and HRESIMS spectral data. RESULTS: Two phragmalin-type limonoids, tabulalin F (1) and tabulalin (2) were isolated. CONCLUSION: Tabulalin F (1) was a new compou ...
DOI:
10.3724/SP.J.1009.2011.00098

15. A New Triterpenoid Saponin from the Leaves of Aralia elata

Author:
Qiu-Hong WANG; Jian ZHANG; Xu MA; Xu-Yan YE; Bing-You YANG; Yong-Gang XIA; Hai-Xue KUANG
Source:
Chinese journal of natural medicines 2011 v.9 no.1 pp. 17-21
ISSN:
1875-5364
Subject:
Aralia elata; chemical composition; chromatography; flavonoids; glycosides; leaves; nuclear magnetic resonance spectroscopy; silica gel
Abstract:
... AIM: To study the chemical constituents of the leaves of Aralia elata (Miq.) Seem, and find new or effective components. METHODS: Compounds were isolated by repeated silica gel, ODS and Sephadex LH-20 column chromatography. The structures were elucidated by NMR and HRESI-MS spectrometry. RESULTS: A triterpenoid saponin and two flavonoid glycosides were isolated from the leaves of A. elata, and the ...
DOI:
10.1016/S1875-5364(11)60012-5

16. A Novel Approach to Characterize Chemical Consistency of Traditional Chinese Medicine Fuzi Lizhong Pills by GC-MS and RRLC-Q-TOFMS

Author:
Hui LIU; Juan SU; Xi YANG; Ya-Jun HE; Hai-Yun LI; Ji YE; Wei-Dong ZHANG
Source:
Chinese journal of natural medicines 2011 v.9 no.4 pp. 267-273
ISSN:
1875-5364
Subject:
Oriental traditional medicine; business enterprises; cluster analysis; gas chromatography; liquid chromatography; mass spectrometry; China
Abstract:
... AIM: To identify the chemical compositions of Fuzi Lizhong Pills, a traditional Chinese medicine that has been used for thousands of years in China. METHODS: Fingerprints of different batches of Fuzi Lizhong Pills were developed by gas chromatography-mass spectrometry (GC-MS) and rapid resolution liquid chromatography coupled with photo-diode array detector and time-of-flight mass spectrometry (RR ...
DOI:
10.1016/S1875-5364(11)60063-0

17. A Novel Bioactive Peptide with Myotropic Activity from Wasp Venoms

Author:
Hong-Li YAN; Wen-Lin CHEN; Ling-Ling CHEN; Ren LAI; Jing-Ze LIU
Source:
Chinese journal of natural medicines 2011 v.9 no.4 pp. 317-320
ISSN:
1875-5364
Subject:
Vespa; amino acids; bioactive properties; bioassays; cDNA libraries; chemical composition; complementary DNA; gel chromatography; high performance liquid chromatography; ileum; mass spectrometry; signal peptide; smooth muscle; venoms; China
Abstract:
... AIM: To study the chemical constituents of the venom of Vespa bicolor Fabricius collected from Shanxi Province, China. METHODS: Gel chromatography and HPLC were applied to isolate a peptide from the venom. Mass spectrometry and Edman degradation were used for its structural characterization. The cDNA encoding vespin-BF precursor was cloned from the cDNA library of the venomous glands. The syntheti ...
DOI:
10.1016/S1875-5364(11)60069-1

18. A Novel Ceramide from the Roots of Derris elliptica

Author:
Hai-Ying LU; Jing-Yu LIANG
Source:
Chinese journal of natural medicines 2011 v.9 no.2 pp. 94-97
ISSN:
1875-5364
Subject:
Derris elliptica; ceramides; chemical composition; chemical structure; chromatography; roots; spectral analysis
Abstract:
... AIM: To study the chemical constituents from the roots of Derris elliptica (Roxb.) Benth. METHODS: The chemical constituents were isolated by various chromatographic methods, and the chemical structures were elucidated on the basis of spectral analysis. RESULT: Four lipid constituents were obtained, including three ceramides, (2S, 3S, 4R, 8E)-2N-[(2′R, 3′)-2′, 3′-dihydroxyhexacosanoyl]-1, 3, 4-tri ...
DOI:
10.3724/SP.J.1009.2011.00094

19. A brief history of artemisinin: Modes of action and mechanisms of resistance

Author:
Feng LU; Xin-Long HE; Culleton Richard; Jun CAO
Source:
Chinese journal of natural medicines 2019 v.17 no.5 pp. 331-336
ISSN:
1875-5364
Subject:
Oriental traditional medicine; Plasmodium falciparum; artemisinin; malaria; mechanism of action; morbidity; mortality; parasites
Abstract:
... The cornerstone of antimalarial treatment, artemisinin, has reduced malaria associated morbidity and mortality worldwide. However, Plasmodium falciparum parasites with reduced sensitivity to artemisinin have emerged, and this threatens malaria control and elimination efforts. In this minireview, we describe the initial development of artemisinin as an antimalarial drug, its use both historically a ...
DOI:
10.1016/S1875-5364(19)30038-X

20. A combination of four effective components derived from Sheng-mai san attenuates hydrogen peroxide-induced injury in PC12 cells through inhibiting Akt and MAPK signaling pathways

Author:
Guo-Sheng CAO; Shao-Xia LI; Yan WANG; Ying-Qiong XU; Yan-Ni LV; Jun-Ping KOU; Bo-Yang YU
Source:
Chinese journal of natural medicines 2016 v.14 no.7 pp. 508-517
ISSN:
1875-5364
Subject:
Oriental traditional medicine; Western blotting; apoptosis; caspase-3; cell viability; hydrogen peroxide; lactate dehydrogenase; malondialdehyde; mitogen-activated protein kinase; signal transduction; staining; superoxide dismutase
Abstract:
... The present study was designed to investigate whether a combination of four effective components derived from Sheng-mai san (SMXZF; ginsenoside Rb1: ginsenoside Rg1: DT-13: Schizandrol A as 6 : 9 : 4 : 5) could attenuate hydrogen peroxide (H2O2)-induced injury in PC12 cells, focusing on the Akt and MAPK pathways . The PC12 cells were exposed to H2O2 (400 μmol·L⁻¹) for 1 h in the presence or absenc ...
DOI:
10.1016/S1875-5364(16)30060-7