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- Maksimov, DaniilA.; Laktionov, PetrP.; Posukh, OlgaV.; Belyakin, StepanN.; Koryakov, DmitryE.
- Chromosoma 2018 v.127 no.1 pp. 85-102
- Drosophila melanogaster; brain; epigenetics; eukaryotic cells; ganglia; gene silencing; genes; genome-wide association study; germ cells; heterochromatin; histones; males; methylation; mutation; salivary glands; somatic cells; spermatogenesis; testes; transcription (genetics)
- ... Histone modifications represent one of the key factors contributing to proper genome regulation. One of histone modifications involved in gene silencing is methylation of H3K9 residue. Present in the chromosomes across different eukaryotes, this epigenetic mark is controlled by SU(VAR)3-9 and its orthologs. Despite SU(VAR)3-9 was discovered over two decades ago, little is known about the details o ...
- Shevchenko, AlexanderI.; Grigor’eva, ElenaV.; Medvedev, SergeyP.; Zakharova, IrinaS.; Dementyeva, ElenaV.; Elisaphenko, EugenyA.; Malakhova, AnastasiaA.; Pavlova, SophiaV.; Zakian, SurenM.
- Chromosoma 2018 v.127 no.1 pp. 129-139
- Microtus; RNA; X chromosome; cell differentiation; chemical compounds; heterochromatin; histones; methyltransferases; models; transcription (genetics); trophoblast; voles
- ... In vole Microtus levis, cells of preimplantation embryo and extraembryonic tissues undergo imprinted X chromosome inactivation (iXCI) which is triggered by a long non-coding nuclear RNA, Xist. At early stages of iXCI, chromatin of vole inactive X chromosome is enriched with the HP1 heterochromatin-specific protein, trimethylated H3K9 and H4K20 attributable to constitutive heterochromatin. In the s ...