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- Thomas, Rachael; Borst, Luke; Rotroff, Daniel; Motsinger-Reif, Alison; Lindblad-Toh, Kerstin; Modiano, Jaime F.; Breen, Matthew
- Chromosome research 2014 v.22 no.3 pp. 305-319
- DNA; chromosome elimination; chromosomes; dog breeds; dogs; gene dosage; hemangiosarcoma; microarray technology; oncogenes; penetrance; prognosis; transcription (genetics)
- ... Canine hemangiosarcoma is a highly aggressive vascular neoplasm associated with extensive clinical and anatomical heterogeneity and a grave prognosis. Comprehensive molecular characterization of hemangiosarcoma may identify novel therapeutic targets and advanced clinical management strategies, but there are no published reports of tumor-associated genome instability and disrupted gene dosage in th ...
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