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1. The CENP-O complex requirement varies among different cell types

Author:
Kagawa, Naoko; Hori, Tetsuya; Hoki, Yuko; Hosoya, Osamu; Tsutsui, Kimiko; Saga, Yumiko; Sado, Takashi; Fukagawa, Tatsuo
Source:
Chromosome research 2014 v.22 no.3 pp. 293-303
ISSN:
0967-3849
Subject:
cell cycle; cell viability; chickens; embryogenesis; fibroblasts; kinetochores; mice; phenotype; proteins
Abstract:
... CENP-U (CENP-50) is a component of the CENP-O complex, which includes CENP-O, CENP-P, CENP-Q, CENP-R, and CENP-U and is constitutively localized at kinetochores throughout the cell cycle in vertebrates. Although CENP-U deficiency results in some mitotic defects in chicken DT40 cells, CENP-U-deficient chicken DT40 cells are viable. To examine the functional roles of CENP-U in an organism-dependent ...
DOI:
10.1007/s10577-014-9404-1
PubMed:
24481920
PubMed Central:
PMC4129241