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- Modan-Moses, Dalit, et al. Show all 8 Authors
- Clinical nutrition 2016 v.35 no.4 pp. 958-962
- adolescents; alkaline phosphatase; anorexia nervosa; blood sampling; blood serum; calcium; diet therapy; disease severity; females; insulin-like growth factor I; longevity; lumbar spine; malnutrition; mice; muscles; osteopenia; pathophysiology; patients; phosphorus; transmembrane proteins
- ... Klotho is a trans-membrane protein which can be shed to act as a hormone; its blood levels may be regulated by the GH/IGF-1 axis. Klotho deficient mice exhibit short lifespan and characteristics of aging and malnutrition, including decreased fat and muscle mass, osteopenia, and impaired fertility. As anorexia nervosa (AN) is characterized by malnutrition and GH resistance, we hypothesized klotho l ...