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1. Elucidation of factors responsible for formation of white flecks in reconstituted fat filled milk powders

Author:
Schmidmeier, C.; O’Gorman, C.; Drapala, K.P.; Waldron, D.S.; O’Mahony, J.A.
Source:
Colloids and surfaces 2019 v.575 pp. 245-255
ISSN:
0927-7757
Subject:
anionic surfactants; chemical bonding; colloids; electrostatic interactions; emulsions; lactose; lipid content; liquids; maltodextrins; minerals; mixing; powders; protein denaturation; reducing agents; skim milk; spray drying; thermal stability; vegetable oil; vitamins; whey protein; yogurt
Abstract:
... Fat filled milk powders (FFMP) are formulated by blending skim milk and vegetable oil, to which lactose, permeate, sugar, maltodextrin, vitamins and minerals may also be added. The liquid mix is usually homogenised and spray dried, with agglomeration and lecithination, to produce powders for a range of end-user applications including drinking milk, yoghurt base and coffee whitening. Thus, it is im ...
DOI:
10.1016/j.colsurfa.2019.03.034

2. Characterization of in vitro and in vivo bioactivity of a ferulic acid-2-Hydroxypropyl-β-cyclodextrin inclusion complex

Author:
Hsu, Chin-Mu; Yu, Song-Cu; Tsai, Fuu-Jen; Tsai, Yuhsin
Source:
Colloids and surfaces 2019 v.180 pp. 68-74
ISSN:
0927-7765
Subject:
bioactive properties; bioavailability; cyclodextrins; differential scanning calorimetry; ferulic acid; hydrophobicity; nuclear magnetic resonance spectroscopy; solubility
Abstract:
... Ferulic acid (FA) belongs to the family of phenolic acids and exhibits a wide variety of biological activities. However, the bioavailability of FA is not optimal, owing to its limited aqueous solubility. Several methods have been developed to increase FA bioavailability and enhance its cytoprotective effects. Complexing FA with cyclodextrins (CDs) may provide an alternative method to approach thes ...
DOI:
10.1016/j.colsurfb.2019.04.020

3. Dual drug loaded liposome bearing apigenin and 5-Fluorouracil for synergistic therapeutic efficacy in colorectal cancer

Author:
Sen, Kacoli; Banerjee, Shubhadeep; Mandal, Mahitosh
Source:
Colloids and surfaces 2019 v.180 pp. 9-22
ISSN:
0927-7765
Subject:
angiogenesis; apigenin; apoptosis; bioavailability; cell proliferation; colorectal neoplasms; cytotoxicity; drug therapy; fluorouracil; fruits; human cell lines; humans; mice; models; nanocarriers; neoplasm cells; synergism; vegetables
Abstract:
... Multidrug-based combinatorial therapeutic regiments which target multiple pathways simultaneously are being utilized as a therapeutic strategy of choice due to reduction in toxicity profile and enhancement of therapeutic index of the individual drugs. 5-Fluorouracil is a clinically approved drug which has limited response rate in the realm of colorectal cancer amelioration, hence our study aims to ...
DOI:
10.1016/j.colsurfb.2019.04.035

4. E-cadherin mediated cell-biomaterial interaction reduces migration of keratinocytes in-vitro

Author:
Dehli, J.; Karlsson, C.; Bizelli-Silveira, C.; Jiang, Xingyu; Kraft, D.; Foss, M.
Source:
Colloids and surfaces 2019 v.180 pp. 326-333
ISSN:
0927-7765
Subject:
adherens junctions; adhesion; cadherins; calcium; cell movement; cell proliferation; colloids; enzyme-linked immunosorbent assay; fibroblasts; fibronectins; human cell lines; interphase; keratinocytes; pathogens; titanium
Abstract:
... Percutaneous devices suffer from imperfect sealing of the epidermis-implant interphase, the so-called three-phase junction, allowing invading pathogens access to colonize the implant at the tissue interface and potentially cause an infection. In skin, one of the key components of the epidermal barrier is the E-cadherin mediated adherens junctions. We investigated the response of a human keratinocy ...
DOI:
10.1016/j.colsurfb.2019.04.010

5. Effect of casein on pure lecithin liposome: Mixed biomacromolecular system for providing superior stabilization to hydrophobic molecules

Author:
Panja, Sudipta; Khatua, Deb Kumar; Halder, Mintu
Source:
Colloids and surfaces 2019 v.180 pp. 298-305
ISSN:
0927-7765
Subject:
beta-carotene; casein; curcumin; drug delivery systems; drugs; electrostatic interactions; encapsulation; hydrophobicity; lecithins; lipid bilayers; lipid composition; models; spectral analysis
Abstract:
... Formulation of new liposoma-based systems can always be in the spotlight for their unique utilization as carriers. Some changes in the composition of lipids may give rise to new mixed liposomes exhibiting modified size and physico-chemical characteristics. Consequently, these display different encapsulating properties toward various molecules. In this work, we have explored the variations in the m ...
DOI:
10.1016/j.colsurfb.2019.04.038

6. Effect of incorporation of montmorillonite on Xylan/Chitosan conjugate scaffold

Author:
Ali, Asif; Bano, Saleheen; Poojary, Satish S.; Kumar, Dhruv; Negi, Yuvraj Singh
Source:
Colloids and surfaces 2019 v.180 pp. 75-82
ISSN:
0927-7765
Subject:
Fourier transform infrared spectroscopy; Maillard reaction; X-ray diffraction; apatite; biodegradation; biomineralization; body fluids; bones; calcium; cell viability; chitosan; crystals; freeze drying; hydrophilicity; mechanical properties; mechanical testing; montmorillonite; polymers; porosity; scanning electron microscopy; tissue engineering; toxicity testing; xylan
Abstract:
... The present study reports the fabrication of Xylan/Chitosan/Montmorillonite (MMT) composite scaffold by freeze drying process with the aim of achieving improved properties for bone tissue engineering applications. The scaffolds were characterized using Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), Scanning electron microscopy (SEM) and mechanical testing. The fabricated ...
DOI:
10.1016/j.colsurfb.2019.04.032

7. Enhanced physico-mechanical, barrier and antifungal properties of soy protein isolate film by incorporating both plant-sourced cinnamaldehyde and facile synthesized zinc oxide nanosheets

Author:
Wu, Juan; Sun, Qi; Huang, Hang; Duan, Ying; Xiao, Gang; Le, Tao
Source:
Colloids and surfaces 2019 v.180 pp. 31-38
ISSN:
0927-7765
Subject:
antifungal properties; biocomposites; color; composite films; food preservation; ingredients; liquids; nanocomposites; nanoparticles; nanosheets; oxygen; packaging; packaging materials; permeability; soy protein isolate; storage modulus; tensile strength; zinc oxide
Abstract:
... In order to exploit multifunctional packaging material, soy protein isolate (SPI) based biocomposite films incorporated with plant-sourced cinnamaldehyde (CIN) and zinc oxide nanoparticles (ZnO NPs) synthesized by a liquid precipitation method were prepared and characterized. The functional actions between cinnamaldehyde and zinc oxide nanoparticles on the physical, mechanical and antifungal prope ...
DOI:
10.1016/j.colsurfb.2019.04.041

8. Green synthesis of Ag nanoflowers using Kalanchoe Daigremontiana extract for enhanced photocatalytic and antibacterial activities

Author:
Molina, Gustavo A.; Esparza, Rodrigo; López-Miranda, J. Luis; Hernández-Martínez, Angel R.; España-Sánchez, Beatriz L.; Elizalde-Peña, Eduardo A.; Estevez, Miriam
Source:
Colloids and surfaces 2019 v.180 pp. 141-149
ISSN:
0927-7765
Subject:
Escherichia coli; Fourier transform infrared spectroscopy; Gram-negative bacteria; Kalanchoe daigremontiana; Staphylococcus aureus; X-ray diffraction; X-ray photoelectron spectroscopy; anisotropy; antibacterial properties; energy-dispersive X-ray analysis; ions; leaves; methylene blue; nanoflowers; nanosilver; photocatalysis; plant extracts; scanning electron microscopy; silver; solvents; ultraviolet-visible spectroscopy; zeta potential
Abstract:
... The synthesis and applications of anisotropic nanostructures have attracted much attention in the last decade. The nanoflower-type structures are one of the nanomaterials with anisotropic structures most investigated because of owing to high densities of edges, corners, and stepped atoms present on their nano-petals. Here, silver nanoparticles obtained by a one-step green synthesis method using ex ...
DOI:
10.1016/j.colsurfb.2019.04.044

9. Hierarchical bioresponsive nanocarriers for codelivery of curcumin and doxorubicin

Author:
Lin, Jian-Tao; Ye, Qing-Bang; Yang, Qing-Jin; Wang, Guan-Hai
Source:
Colloids and surfaces 2019 v.180 pp. 93-101
ISSN:
0927-7765
Subject:
apoptosis; blood circulation; coatings; crosslinking; curcumin; disulfide bonds; doxorubicin; drug therapy; human cell lines; hydrogels; nanocarriers; neoplasm cells; neoplasms; pH; synergism
Abstract:
... Hierarchical responsive nanocarriers have received much attention for targeted delivery of chemotherapeutics. In this study, we designed pH and redox dual-stage responsive nanocarriers in the different delivery stages for co-delivery phosphorylated curcumin (p-Cur) with doxorubicin (Dox). The MSNs nanocarriers were functionalized via specific cleavable PEGylation and hydrogel coating crosslinked b ...
DOI:
10.1016/j.colsurfb.2019.04.023

10. Improved electrocatalytic activity of Au@Fe3O4 magnetic nanoparticles for sensitive dopamine detection

Author:
Thamilselvan, Annadurai; Manivel, Perumal; Rajagopal, Venkatachalam; Nesakumar, Noel; Suryanarayanan, Vembu
Source:
Colloids and surfaces 2019 v.180 pp. 1-8
ISSN:
0927-7765
Subject:
X-ray diffraction; dopamine; electrochemistry; electrodes; gold; humans; iron oxides; magnetism; nanocomposites; nanogold; nanoparticles; scanning electron microscopy; sensors (equipment); transmission electron microscopy; urine
Abstract:
... Substantially, noble metals are important for the development of low-cost, sensitive, selective, superior performance, and portable electrochemical sensors. Herein, we describe gold (Au) nanoparticles (NPs) systematically decorated with magnetic Fe3O4 nanocomposites on the fabrication of sensitive dopamine sensor is described. Magnetic Au@Fe3O4 nanocomposites were prepared by reducing HAuCl4 on th ...
DOI:
10.1016/j.colsurfb.2019.04.034

11. Improved synthesis and characterization of cholesteryl oleate-loaded cationic solid lipid nanoparticles with high transfection efficiency for gene therapy applications

Author:
Suñé-Pou, Marc; Limeres, María J.; Nofrerias, Isaac; Nardi-Ricart, Anna; Prieto-Sánchez, Silvia; El-Yousfi, Younes; Pérez-Lozano, Pilar; García-Montoya, Encarna; Miñarro-Carmona, Montserrat; Ticó, Josep Ramón; Hernández-Munain, Cristina; Suñé, Carlos; Suñé-Negre, Josep Mª
Source:
Colloids and surfaces 2019 v.180 pp. 159-167
ISSN:
0927-7765
Subject:
freeze drying; gene therapy; good manufacturing practices; guidelines; in vivo studies; manufacturing; nanoparticles; nucleic acids; oleic acid; toxicity; transfection
Abstract:
... The development of new nanoparticle formulations that are capable of high transfection efficiency without toxicity is essential to provide new tools for gene therapy. However, the issues of complex, poorly reproducible manufacturing methods, and low efficiencies during in vivo testing have prevented translation to the clinic. We have previously reported the use of cholesteryl oleate as a novel exc ...
DOI:
10.1016/j.colsurfb.2019.04.037

12. Interaction of natural compounds with biomembrane models: A biophysical approach for the Alzheimer’s disease therapy

Author:
Andrade, Stephanie; Ramalho, Maria J.; Loureiro, Joana A.; Pereira, Maria Carmo
Source:
Colloids and surfaces 2019 v.180 pp. 83-92
ISSN:
0927-7765
Subject:
Alzheimer disease; caffeine; cell membranes; cholesterol; clinical trials; drugs; fluorescence; gallic acid; light scattering; membrane fluidity; models; peptides; pharmacokinetics; spectroscopy; tannins; therapeutics
Abstract:
... Natural compounds such as caffeine (CA), gallic acid (GA) and tannic acid (TA) have been reported to be useful for Alzheimer’s disease (AD) therapy. It was proved that some natural compounds inhibit the formation of senil plaques composed by beta-amyloid peptide (Aβ), a hallmark of AD. Evidences suggest that the therapeutic activity of compounds depends of their interaction with biological membran ...
DOI:
10.1016/j.colsurfb.2019.04.019

13. Interactions of miltefosine with erythrocyte membrane proteins compared to those of ionic surfactants

Author:
Alonso, Lais; Cardoso, Éder Jéferson Souza; Mendanha, Sebastião Antônio; Alonso, Antonio
Source:
Colloids and surfaces 2019 v.180 pp. 23-30
ISSN:
0927-7765
Subject:
albumins; antileishmanials; blood plasma; electron paramagnetic resonance spectroscopy; electrostatic interactions; erythrocyte membrane; hydrophobic bonding; ionic surfactants; leishmaniasis; mechanism of action; membrane proteins; quaternary ammonium compounds; sodium dodecyl sulfate; zwitterions
Abstract:
... For miltefosine (MIL), a zwitterionic alkylphospholipid approved for leishmaniasis treatment, the mechanism of action is not well established. Electron paramagnetic resonance (EPR) spectroscopy has indicated that the interaction of MIL with membrane proteins has similarities to that of ionic surfactants. A general concern about leishmanicides is their high hemolytic potential, so we decided to com ...
DOI:
10.1016/j.colsurfb.2019.04.040

14. Polymeric micelles of pluronic F127 reduce hemolytic potential of amphiphilic drugs

Author:
Feitosa, Valker Araujo; Almeida, Vinícius Cordeiro de; Malheiros, Barbara; Castro, Raphael Dias de; Barbosa, Leandro Ramos Souza; Cerize, Natalia Neto Pereira; Rangel-Yagui, Carlota de Oliveira
Source:
Colloids and surfaces 2019 v.180 pp. 177-185
ISSN:
0927-7765
Subject:
cetyltrimethylammonium bromide; composite polymers; drugs; encapsulation; hemolysis; intravenous injection; micelles; polyethylene glycol; propylene oxide; small-angle X-ray scattering; surfactants
Abstract:
... One of the main toxicities associated to intravenous administration of amphiphilic drugs is pronounced hemolytic activity. To overcome this limitation, we investigated the anti-hemolytic properties of polymeric micelles of Pluronics, triblock copolymers of poly(ethylene oxide) and poly(propylene oxide). We studied the encapsulation of the amphiphilic compound miltefosine (HePC) into polymeric mice ...
DOI:
10.1016/j.colsurfb.2019.04.045

15. RGD peptide-decorated micelles assembled from polymer–paclitaxel conjugates towards gastric cancer therapy

Author:
Shi, Jingwen; Liu, Shuiping; Yu, Yuan; He, Changyu; Tan, Lianjiang; Shen, Yu-Mei
Source:
Colloids and surfaces 2019 v.180 pp. 58-67
ISSN:
0927-7765
Subject:
adverse effects; apoptosis; cell proliferation; drug delivery systems; drugs; glutathione; hydrodynamics; in vivo studies; micelles; nanoparticles; neoplasm cells; polyethylene glycol; stomach neoplasms
Abstract:
... Development of polymer-drug conjugate capable of controlled drug release is urgently needed for gastric cancer therapy. Herein, arginine-glycine-aspartic acid (RGD)-decorated polyethylene glycol (PEG)-paclitaxel (PTX) conjugates containing disulfide linkage were synthesized. The amphiphilic PEG-PTX conjugates were found to assemble into micelles (RGD@Micelles), which would be decomposed under the ...
DOI:
10.1016/j.colsurfb.2019.04.042

16. Selective endothelialization and alleviation of neointimal hyperplasia by functionalizing the Ti-O surface with l-selenocystine and KREDVC

Author:
Xie, Yinhong; Zeng, Zheng; Fan, Yonghong; Zhang, Yu; Liu, Junfeng; Li, Weijie; Weng, Yajun
Source:
Colloids and surfaces 2019 v.180 pp. 168-176
ISSN:
0927-7765
Subject:
adhesion; biocompatibility; blood coagulation factors; coatings; corrosion; endothelial cells; hyperplasia; in vivo studies; nitric oxide; optical isomerism; peptides; smooth muscle; synergism; titanium dioxide
Abstract:
... Due to their relatively good biocompatibility and inactivity, titanium oxide films (Ti-O) are used in the coating of coronary stents, which reduces metal corrosion, slows metal ion release, and improves endothelial cell (EC) compatibility. Here, we report further functionalizing Ti-O with biological cues for selective endothelialization. Selenocystine with an l- or a d-enantiomer was first immobil ...
DOI:
10.1016/j.colsurfb.2019.04.039

17. Short fluorocarbon chains containing hydrophobic nanofibrous membranes with improved hemocompatibility, anticoagulation and anti-fouling performance

Author:
Wang, Ying; Liu, Yuqing; Liu, Menglong; Qian, Wei; Zhou, Daijun; Liu, Tengfei; Luo, Gaoxing; Xing, Malcolm
Source:
Colloids and surfaces 2019 v.180 pp. 49-57
ISSN:
0927-7765
Subject:
absorption; adhesion; adsorption; anticoagulants; antifouling activities; bacterial adhesion; biocompatibility; blood platelets; bovine serum albumin; coagulation; colloids; composite polymers; cytotoxicity; erythrocytes; hemolysis; humans; hydrophobicity; nanofibers; perfluorocarbons; prothrombin; thromboplastin
Abstract:
... Thromboembolic diseases have become one of the most hazardous and mortal diseases to human life. In this paper, a highly hydrophobic nanofibrous membrane was prepared via electrospinning of PCL-b-PHFBA (polycaprolactone -b- poly (heptafluoro butyl acrylate)) block copolymers. The nanofibrous membranes showed high hydrophobicity with a water contact angle of ˜136° due to their rough nanofibrous sur ...
DOI:
10.1016/j.colsurfb.2019.01.025

18. Surface-modified PLGA nanoparticles with PEG/LA-chitosan for targeted delivery of arsenic trioxide for liver cancer treatment: Inhibition effects enhanced and side effects reduced

Author:
Song, Xiaoli; Wang, Juan; Xu, Yue; Shao, Hongxia; Gu, Jun
Source:
Colloids and surfaces 2019 v.180 pp. 110-117
ISSN:
0927-7765
Subject:
adverse effects; arsenic oxide; biocompatibility; chitosan; cytotoxicity; drug delivery systems; drug therapy; drugs; encapsulation; evaporation; hepatocytes; humans; in vivo studies; kidneys; leukemia; liver; liver neoplasms; nanoparticles; polyethylene glycol
Abstract:
... Arsenic trioxide (As2O3), an effective drug for leukemia, is limited to be used for solid tumor treatment due to its high side effects. In this study, polyethylene glycol (PEG) and lactobionic acid (LA) modified chitosan (PLC) was synthesized and was used to coat poly(lactide-co-glycolide) (PLGA) nanoparticles for encapsulation and targeted release of As2O3 in liver cancer treatment. The As2O3-loa ...
DOI:
10.1016/j.colsurfb.2019.04.036

19. Titania nanotubes promote osteogenesis via mediating crosstalk between macrophages and MSCs under oxidative stress

Author:
Shen, Xinkun; Yu, Yonglin; Ma, Pingping; Luo, Zhong; Hu, Yan; Li, Menghuan; He, Ye; Zhang, Yangyang; Peng, Zhihong; Song, Guanbin; Cai, Kaiyong
Source:
Colloids and surfaces 2019 v.180 pp. 39-48
ISSN:
0927-7765
Subject:
bone formation; chemokine CCL2; coculture; inflammation; interleukin-8; macrophages; mesenchymal stromal cells; mitogen-activated protein kinase; monocytes; nanotubes; osteoblasts; oxidation; oxidative stress; titanium; titanium dioxide; transcription factor NF-kappa B
Abstract:
... Before mesenchymal stem cells (MSCs) adhere to the surface of an implant and differentiate into osteoblasts, monocytes (especially macrophages) arrive at the bone injury site and interact with the implant and subsequent MSCs. In our previous study, large titania nanotubes (TNT110) had been verified to endow superior oxidation resistance to osteoblasts. The early regulation between macrophages and ...
DOI:
10.1016/j.colsurfb.2019.04.033

20. Unsaturation of the phospholipid side-chain influences its interaction with cyclodextrins: A spectroscopic exploration using a phenazinium dye

Author:
Sett, Riya; Paul, Bijan K.; Guchhait, Nikhil
Source:
Colloids and surfaces 2019 v.180 pp. 150-158
ISSN:
0927-7765
Subject:
dyes; fluorescence; light scattering; phospholipids; photosensitizing agents; spectroscopy
Abstract:
... The interaction of a cationic photosensitizer Safranin-O with liposome membranes having similar surface charge (negative) but differing in the presence of saturation on the lipid side-chain has been studied. To this end, dimyristoyl-l-R-phosphatidylglycerol (DMPG) and 1,2-dioleoyl-sn-glycero-3-phospho-(1′-rac-glycerol) (DOPG) phospholipids were employed to prepare small unilamellar vesicles. The d ...
DOI:
10.1016/j.colsurfb.2019.04.046