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- Mealey, Katrina L.; Minch, Jonathan D.; White, Stephen N.; Snekvik, Kevin R.; Mattoon, John S.
- Comparative Hepatology 2010 v.9 no.6 pp. 1
- Shetland Sheepdog; adenosine triphosphate; animal models; binding sites; cholestasis; cysts (pathology); dog diseases; dogs; gall bladder; genes; mutation; pathophysiology; people; pregnancy; protein synthesis; proteins; stop codon
- ... Background: ABCB4 functions as a phosphatidylcholine translocater, flipping phosphatidylcholine across hepatocyte canalicular membranes into biliary canaliculi. In people, ABCB4 gene mutations are associated with several disease syndromes including intrahepatic cholestasis of pregnancy, progressive familial intrahepatic cholestasis (type 3), primary biliary cirrhosis, and cholelithiasis. Hepatobil ...
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