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- Aromolaran, Olufemi; Beder, Thomas; Oswald, Marcus; Oyelade, Jelili; Adebiyi, Ezekiel; Koenig, Rainer
- Computational and Structural Biotechnology Journal 2020
- Drosophila melanogaster; RNA interference; amino acid sequences; artificial intelligence; computational methodology; essential genes; gene regulatory networks; humans; models; prediction; protein-protein interactions; topology; transcription (genetics); viability
- ... Genes are termed to be essential if their loss of function compromises viability or results in profound loss of fitness. On the genome scale, these genes can be determined experimentally employing RNAi or knockout screens, but this is very resource intensive. Computational methods for essential gene prediction can overcome this drawback, particularly when intrinsic (e.g. from the protein sequence) ...
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