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- Bignon, Emmanuelle; Rizza, Salvatore; Filomeni, Giuseppe; Papaleo, Elena
- Computational and Structural Biotechnology Journal 2019 v.17 pp. 415-429
- neuronal nitric oxide synthase, etc ; NADP (coenzyme); arginine; biotechnology; citrulline; endothelial nitric oxide synthase; inducible nitric oxide synthase; nitric oxide; oxidation; oxygen; Show all 10 Subjects
- ... Nitric oxide (NO) is an essential signaling molecule in the regulation of multiple cellular processes. It is endogenously synthesized by NO synthase (NOS) as the product of L-arginine oxidation to L-citrulline, requiring NADPH, molecular oxygen, and a pterin cofactor. Two NOS isoforms are constitutively present in cells, nNOS and eNOS, and a third is inducible (iNOS). Despite their biological rele ...