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- Wu, Kezhou; Laouar, Leila; Dong, Rachael; Elliott, Janet A.W.; Jomha, Nadr M.
- Cryobiology 2019 v.88 pp. 98-105
- additives; antioxidants; ascorbic acid; cartilage; cell viability; chondrocytes; chondroitin sulfate; cryopreservation; cryoprotectants; cytotoxicity; glucosamine; oxidation; pyrazines; swine; tissue banks; viability assays; vitrification
- ... Cryoprotective agents (CPAs) are used in cryopreservation protocols to achieve vitrification. However, the high CPA concentrations required to vitrify a tissue such as articular cartilage are a major drawback due to their cellular toxicity. Oxidation is one factor related to CPA toxicity to cells and tissues. Addition of antioxidants has proven to be beneficial to cell survival and cellular functi ...