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- Author:
- Oguro, Yoshifumi; Yamazaki, Harutake; Ara, Satoshi; Shida, Yosuke; Ogasawara, Wataru; Takagi, Masamichi; Takaku, Hiroaki
- Source:
- Current genetics 2017 v.63 no.4 pp. 751-763
- ISSN:
- 0172-8083
- Subject:
- Lipomyces starkeyi; animals; biodiesel; biosynthesis; cost effectiveness; drug resistance; feedstocks; gene targeting; genes; genetic engineering; homologous recombination; industry; lipids; loci; metabolic engineering; mutants; plants (botany); yeasts
- Abstract:
- ... Microbial lipids are sustainable feedstock for the production of oleochemicals and biodiesel. Oleaginous yeasts have recently been proposed as alternative lipid producers to plants and animals to promote sustainability in the chemical and fuel industries. The oleaginous yeast Lipomyces starkeyi has great industrial potential as an excellent lipid producer. However, improvement of its lipid product ...
- DOI:
- 10.1007/s00294-017-0679-6
-
https://dx.doi.org/10.1007/s00294-017-0679-6
- Author:
- Islam, Kazi T.; Bond, Jason P.; Fakhoury, Ahmad M.
- Source:
- Current genetics 2017 v.63 no.4 pp. 723-738
- ISSN:
- 0172-8083
- Subject:
- Fusarium virguliforme; agglutinins; arabinose; carbon; death; fructose; galactose; genes; glucose; greenhouses; maltose; microbial biomass; microscopy; mutants; oxidation; pectins; phloem; plant pathogenic fungi; protein kinases; roots; soybeans; sucrose; virulence; wheat germ; xylem vessels; xylose; yeasts
- Abstract:
- ... Fusarium virguliforme is a soil-borne pathogenic fungus that causes sudden death syndrome (SDS) in soybean. Its pathogenicity is believed to require the activity of cell-wall-degrading enzymes (CWDEs). The sucrose non-fermenting protein kinase 1 gene (SNF1) is a key component of the glucose de-repression pathway in yeast, and a regulator of gene expression for CWDEs in some plant pathogenic fungi. ...
- DOI:
- 10.1007/s00294-017-0676-9
-
https://dx.doi.org/10.1007/s00294-017-0676-9
- Author:
- Rai, Ragini; Laloraya, Shikha
- Source:
- Current genetics 2017 v.63 no.4 pp. 765-776
- ISSN:
- 0172-8083
- Subject:
- chromosome elimination; mutants; mutation; replication origin; yeast artificial chromosomes
- Abstract:
- ... Replication of linear chromosomes is facilitated by firing of multiple replication origins that ensures timely duplication of the entire chromosome. The Smc5/6 complex is thought to play an important role in replication by its involvement in the restart of collapsed replication forks. Here, we present genetic evidence for functional interaction between replication origin distribution and two subun ...
- DOI:
- 10.1007/s00294-017-0680-0
-
https://dx.doi.org/10.1007/s00294-017-0680-0
- Author:
- Mahendrawada, Lakshmi; Rai, Ragini; Kothiwal, Deepash; Laloraya, Shikha
- Source:
- Current genetics 2017 v.63 no.4 pp. 627-645
- ISSN:
- 0172-8083
- Subject:
- DNA damage; mutants; mutation; phenotype; viability; yeast artificial chromosomes; yeasts
- Abstract:
- ... Genetic information in cells is encrypted in DNA molecules forming chromosomes of varying sizes. Accurate replication and partitioning of chromosomes in the crowded cellular milieu is a complex process involving duplication, folding and movement. Longer chromosomes may be more susceptible to mis-segregation or DNA damage and there may exist specialized physiological mechanisms preventing this. Her ...
- DOI:
- 10.1007/s00294-016-0665-4
-
https://dx.doi.org/10.1007/s00294-016-0665-4
- Author:
- Toh-e, Akio; Ohkusu, Misako; Shimizu, Kiminori; Takahashi-Nakaguchi, Azusa; Kawamoto, Susumu; Ishiwada, Naruhiko; Watanabe, Akira; Kamei, Katsuhiko
- Source:
- Current genetics 2017 v.63 no.4 pp. 697-707
- ISSN:
- 0172-8083
- Subject:
- Cryptococcus neoformans; Saccharomyces cerevisiae; allantoin; fungi; genes; genetic background; metabolites; mutants; mutation; nitrogen; orotic acid; phenotype; proline; symporters; transcription factors; uracil; uridine; virulence
- Abstract:
- ... It is well known that 5-fluoroorotic acid (5-FOA)-resistant mutants isolated from wild-type Cryptococcus neoformans are exclusively either ura3 or ura5 mutants. Unexpectedly, many of the 5-FOA-resistant mutants isolated in our selective regime were Ura⁺. We identified CNM00460 as the gene responsible for these mutations. Cnm00460 belongs to the nucleobase cation symporter 1/purine-related transpor ...
- DOI:
- 10.1007/s00294-016-0672-5
-
https://dx.doi.org/10.1007/s00294-016-0672-5
- Author:
- Kusuya, Yoko; Hagiwara, Daisuke; Sakai, Kanae; Yaguchi, Takashi; Gonoi, Tohru; Takahashi, Hiroki
- Source:
- Current genetics 2017 v.63 no.4 pp. 777-789
- ISSN:
- 0172-8083
- Subject:
- Aspergillus fumigatus; biosynthesis; conidia; conidiation; copper; homeostasis; melanin; mutants; toxicity; transcription factors; transporters; yeasts
- Abstract:
- ... Copper (Cu) is an essential metal for all living organisms, although it is toxic in excess. Filamentous fungus must acquire copper from its environment for growth. Despite its essentiality for growth, the mechanisms that maintain copper homeostasis are not fully understood in filamentous fungus. To gain insights into copper homeostasis, we investigated the roles of a copper transcription factor Af ...
- DOI:
- 10.1007/s00294-017-0681-z
-
https://dx.doi.org/10.1007/s00294-017-0681-z
- Author:
- Matar, Khalid Abdelkarim Omer; Chen, Xiaofeng; Chen, Dongjie; Anjago, Wilfred Mabeche; Norvienyeku, Justice; Lin, Yahong; Chen, Meilian; Wang, Zonghua; Ebbole, Daniel J.; Lu, Guo-dong
- Source:
- Current genetics 2017 v.63 no.4 pp. 685-696
- ISSN:
- 0172-8083
- Subject:
- 2-deoxyglucose; Aspergillus nidulans; Magnaporthe oryzae; allyl alcohol; appressoria; beta-glucosidase; carbon; cell walls; conidia; conidiation; feruloyl esterase; gene expression; gene expression regulation; genes; glucose; host plants; hyphae; leaves; microorganisms; mutants; pathogenesis; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; vegetative growth; virulence
- Abstract:
- ... Carbon catabolite repression (CCR) is a common regulatory mechanism used by microorganisms to prioritize use of a preferred carbon source (usually glucose). The CreC WD40-repeat protein is a major component of the CCR pathway in Aspergillus nidulans. To clarify the function of the CreC ortholog from Magnaporthe oryzae in regulating gene expression important for pathogenesis, MoCreC was identified ...
- DOI:
- 10.1007/s00294-016-0668-1
-
https://dx.doi.org/10.1007/s00294-016-0668-1