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You searched for: Journal Current genetics Remove constraint Journal: Current genetics Publication Year 1994 Remove constraint Publication Year: 1994 Source 1994 v.26 no.4 Remove constraint Source: 1994 v.26 no.4 Subject amino acid sequences Remove constraint Subject: amino acid sequences
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1. Saccharomyces cerevisiae YDR1, which encodes a member of the ATP-binding cassette (ABC) superfamily, is required for multidrug resistance

Author:
Hirata, D.; Yano, K.; Miyahara, K.; Mijakawa, T.
Source:
Current genetics 1994 v.26 no.4 pp. 285-294
ISSN:
0172-8083
Subject:
transport proteins; structural genes; drugs; Saccharomyces cerevisiae; mutagenicity; amino acid sequences; nucleotide sequences; plasma membrane; glycoproteins; drug resistance
Abstract:
... A multidrug resistance gene, YDR1, of Saccharomyces cerevisiae, which encodes a 170-kDa protein of a member of the ABC superfamily, was identified. Disruption of YDR1 resulted in hypersensitivity to cycloheximide, cerulenin, compactin, staurosporine and fluphenazine, indicating that YDR1 is an important determinant of cross resistance to apparently-unrelated drugs. The Ydr1 protein bears the highe ...
DOI:
10.1007/BF00310491
PubMed:
7882421

2. The yeast protein Mrs6p, a homologue of the rabGDI and human choroideraemia proteins, affects cytoplasmic and mitochondrial functions

Author:
Ragnini, A.; Teply, R.; Waldherr, M.; Voskova, A.; Schweyen, R.J.
Source:
Current genetics 1994 v.26 no.4 pp. 308-314
ISSN:
0172-8083
Subject:
metabolism; structural genes; guanosine triphosphate; G-proteins; Saccharomyces cerevisiae; amino acid sequences; mitochondria; nucleotide sequences
Abstract:
... MRS6 is a newly-identified gene in the yeast Saccharomyces cerevisiae. Its product Mrs6p shows significant homology to the mammalian GDP dissociation inhibitor (GDI) of Rab/Ypt-type small G proteins and to the human choroideraemia protein (CHM), the component A of Rab-specific GGTase II. The interaction of Mrs6p with G proteins is indicated by our observation that the MRS6 gene suppresses the effe ...
DOI:
10.1007/BF00310494
PubMed:
7882424