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Current opinion in biotechnology
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7978-2022
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2022 v.76
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- Author:
- Chester Pham; Peter J. Stogios; Alexei Savchenko; Radhakrishnan Mahadevan
- Source:
- Current opinion in biotechnology 2022 v.76 pp. 102753
- ISSN:
- 0958-1669
- Subject:
- biosensors; biotechnology; diagnostic techniques; ligands; point-of-care systems; transcription factors
- Abstract:
- ... Transcription factor (TF)‐based biosensors have been applied in biotechnology for a variety of functions, including protein engineering, dynamic control, environmental detection, and point-of-care diagnostics. Such biosensors are promising analytical tools due to their wide range of detectable ligands and modular nature. However, designing biosensors tailored for applications of interest with the ...
- DOI:
- 10.1016/j.copbio.2022.102753
- https://doi.org/10.1016/j.copbio.2022.102753
- Author:
- Chris G Carter; M Basseer Codabaccus
- Source:
- Current opinion in biotechnology 2022 v.76 pp. 102734
- ISSN:
- 0958-1669
- Subject:
- aquaculture; aquaculture feeds; biotechnology; commercialization; ingredients; nutrition; nutritive value
- Abstract:
- ... Aquaculture is critical for ensuring global food and nutrition security, and fed-aquaculture, which depends on formulated nutritionally balanced manufactured feeds, must be sustainable. Single-cell ingredients (SCI) are predicted to play a significant role in future aquafeeds and have the potential to underpin sustainable fed-aquaculture for many species. The value of an aquafeed ingredient includ ...
- DOI:
- 10.1016/j.copbio.2022.102734
- https://doi.org/10.1016/j.copbio.2022.102734
- Author:
- Bill Whitford; Daniel Jones; Sean Kinnane
- Source:
- Current opinion in biotechnology 2022 v.76 pp. 102717
- ISSN:
- 0958-1669
- Subject:
- biopharmaceuticals; biotechnology; ecological footprint; human health; human resources; process design; product life cycle
- Abstract:
- ... Biopharmaceutical manufacturing provides products yielding value in human health. Nevertheless, many desire to reduce its environmental footprint with science-based approaches to environmental burden reduction, and a rational design of solutions. Pharmaceutical suppliers, academia, and service providers are cooperating to, for example, define and educate those concerned regarding the paths to more ...
- DOI:
- 10.1016/j.copbio.2022.102717
- https://doi.org/10.1016/j.copbio.2022.102717
- Author:
- James F Zawada; David Burgenson; Gang Yin; Trevor J Hallam; James R Swartz; Robert D Kiss
- Source:
- Current opinion in biotechnology 2022 v.76 pp. 102719
- ISSN:
- 0958-1669
- Subject:
- amino acids; biopharmaceuticals; biotechnology; cell-free protein synthesis; evolution; humans
- Abstract:
- ... Cell-free protein synthesis (CFPS) technologies have grown from lab-scale research tools to biopharmaceutical production at the Good Manufacturing Practice manufacturing scale. Multiple human clinical trials are in progress with CFPS-based products. In addition, applications of CFPS in research have continued to expand over the years and play an important role in biopharmaceutical product discover ...
- DOI:
- 10.1016/j.copbio.2022.102719
- https://doi.org/10.1016/j.copbio.2022.102719
- Author:
- Anastasia Sveshnikova; Homa MohammadiPeyhani; Vassily Hatzimanikatis
- Source:
- Current opinion in biotechnology 2022 v.76 pp. 102722
- ISSN:
- 0958-1669
- Subject:
- biochemical pathways; biotechnology; enzymatic reactions
- Abstract:
- ... The metabolic engineering community relies on computational methods for pathway design to produce important small molecules in microbial hosts. Metabolic network databases are continuously curated and updated with known and novel reactions that expand the known biochemistry based on different sets of enzymatic reaction rules. To address the complexity of the metabolic networks, elaborate methods w ...
- DOI:
- 10.1016/j.copbio.2022.102722
- https://doi.org/10.1016/j.copbio.2022.102722
- Author:
- Artur Ruszczak; Simona Bartkova; Marta Zapotoczna; Ott Scheler; Piotr Garstecki
- Source:
- Current opinion in biotechnology 2022 v.76 pp. 102755
- ISSN:
- 0958-1669
- Subject:
- antibiotic resistance; antibiotics; biotechnology
- Abstract:
- ... Application of droplet-based methods enables (i) faster detection, (ii) increased sensitivity, (iii) characterization of the level of heterogeneity in response to antibiotics by bacterial populations, and (iv) expanded screening of the effectiveness of antibiotic combinations. Hereby, we discuss the key steps and parameters of droplet-based experiments to investigate antimicrobial resistance. We a ...
- DOI:
- 10.1016/j.copbio.2022.102755
- https://doi.org/10.1016/j.copbio.2022.102755
- Author:
- Heather S Deter; Ting Lu
- Source:
- Current opinion in biotechnology 2022 v.76 pp. 102730
- ISSN:
- 0958-1669
- Subject:
- biotechnology; cell communication; synthetic biology
- Abstract:
- ... Synthetic microbial consortia represent a frontier of synthetic biology that promises versatile engineering of cellular functions. They are primarily developed through the design and construction of cellular interactions that coordinate individual dynamics and generate collective behaviors. Here we review recent advances in the engineering of synthetic communities through cellular-interaction prog ...
- DOI:
- 10.1016/j.copbio.2022.102730
- https://doi.org/10.1016/j.copbio.2022.102730
- Author:
- Wentao Dong; Eshaan S Rawat; Gregory Stephanopoulos; Monther Abu-Remaileh
- Source:
- Current opinion in biotechnology 2022 v.76 pp. 102739
- ISSN:
- 0958-1669
- Subject:
- biotechnology; diabetes; isotopes; metabolic flux analysis; metabolism; metabolites; neurodegenerative diseases
- Abstract:
- ... Biochemical characterization of metabolism provides molecular insights for understanding biology in health and disease. Over the past decades, metabolic perturbations have been implicated in cancer, neurodegeneration, and diabetes, among others. Isotope tracing is a technique that allows tracking of labeled atoms within metabolites through biochemical reactions. This technique has become an integr ...
- DOI:
- 10.1016/j.copbio.2022.102739
- https://doi.org/10.1016/j.copbio.2022.102739
- Author:
- Fernanda Piorino; Alexandra T Patterson; Mark P Styczynski
- Source:
- Current opinion in biotechnology 2022 v.76 pp. 102738
- ISSN:
- 0958-1669
- Subject:
- biomarkers; biotechnology; cost effectiveness; disease diagnosis; equipment; patients; point-of-care systems; quantitative analysis
- Abstract:
- ... Low-cost, point-of-care (POC) devices that allow fast, on-site disease diagnosis could have a major global health impact, particularly if they can provide quantitative measurement of molecules indicative of a diseased state (biomarkers). Accurate quantification of biomarkers in patient samples is already challenging when research-grade, sophisticated equipment is available; it is even more difficu ...
- DOI:
- 10.1016/j.copbio.2022.102738
- https://doi.org/10.1016/j.copbio.2022.102738
- Author:
- Lir Beck; Tamar Geiger
- Source:
- Current opinion in biotechnology 2022 v.76 pp. 102736
- ISSN:
- 0958-1669
- Subject:
- biomedical research; biotechnology; genomics; mass spectrometry; proteomics; single cell protein; transcriptomics
- Abstract:
- ... Single-cell analyses characterize individual cells, allowing their clustering and characterization in an unsupervised manner. Single-cell genomics and transcriptomics dominate the field of single-cell analysis, however, these often do not accurately reflect cellular functions. In contrast, single-cell protein analyses were until recently only performed using antibody-based approaches. This review ...
- DOI:
- 10.1016/j.copbio.2022.102736
- https://doi.org/10.1016/j.copbio.2022.102736
- Author:
- Inbal Vaknin; Roee Amit
- Source:
- Current opinion in biotechnology 2022 v.76 pp. 102728
- ISSN:
- 0958-1669
- Subject:
- DNA; biotechnology; flow cytometry; gene expression
- Abstract:
- ... Understanding the grammar of enhancers and how they regulate gene expression is key for both basic research and for the pharma and biotech industries. The design and characterization of synthetic enhancers can expand the known regulatory space. This is achieved by the utilization of DNA Oligo Libraries (OLs), which facilitates screening of as many as millions of synthetic enhancer variants simulta ...
- DOI:
- 10.1016/j.copbio.2022.102728
- https://doi.org/10.1016/j.copbio.2022.102728
- Author:
- Balaji Balagurunathan; Hua Ling; Won Jae Choi; Matthew Wook Chang
- Source:
- Current opinion in biotechnology 2022 v.76 pp. 102740
- ISSN:
- 0958-1669
- Subject:
- biotechnology; commercialization; feeds; feedstocks; foods; genetic engineering; genomics; issues and policy; protein synthesis; single cell protein; synthetic biology
- Abstract:
- ... Single-cell proteins (SCPs) have been widely used in human food and animal feed applications, still, there are challenges in their production and commercialization. Recently, advances in microbial synthetic biology, genomic engineering, and biofoundry technologies have offered capabilities to effectively and rapidly engineer microorganisms for improving the productivity, nutritional, and functiona ...
- DOI:
- 10.1016/j.copbio.2022.102740
- https://doi.org/10.1016/j.copbio.2022.102740
- Author:
- Zhiguang Zhu; Haiyan Song; Yuanming Wang; Yi-Heng PJ Zhang
- Source:
- Current opinion in biotechnology 2022 v.76 pp. 102751
- ISSN:
- 0958-1669
- Subject:
- biosensors; biotechnology; catalytic activity; electron transfer; immobilized enzymes
- Abstract:
- ... The development of electrochemical biosensors has gained tremendous attention. Protein engineering has been applied for enhancing properties of native redox enzymes, such as selectivity, sensitivity, and stability required for applicable biosensors. This review highlights recent advances of protein engineering to improve enzymatic catalysis of biosensors, facilitate electron transfer and enzyme im ...
- DOI:
- 10.1016/j.copbio.2022.102751
- https://doi.org/10.1016/j.copbio.2022.102751
- Author:
- Esteban Marcellin; Largus T Angenent; Lars K Nielsen; Bastian Molitor
- Source:
- Current opinion in biotechnology 2022 v.76 pp. 102723
- ISSN:
- 0958-1669
- Subject:
- biotechnology; carbon; climate change; fermentation; food production; fossil fuels; protein synthesis; single cell protein; synthetic biology
- Abstract:
- ... Current food production practices contribute significantly to climate change. To transition into a sustainable future, a combination of new food habits and a radical food production innovation must occur. Single-cell protein from microbial fermentation can profoundly impact sustainability. This review paper explores opportunities offered by gas fermentation to completely replace our reliance on fo ...
- DOI:
- 10.1016/j.copbio.2022.102723
- https://doi.org/10.1016/j.copbio.2022.102723
- Author:
- Alex Durkin; Miao Guo; Stefan Wuertz; David C Stuckey
- Source:
- Current opinion in biotechnology 2022 v.76 pp. 102735
- ISSN:
- 0958-1669
- Subject:
- biotechnology; circular economy; cost effectiveness; energy; environmental impact; feeds; flavanones; food processing; isoflavones; single cell protein; wastewater
- Abstract:
- ... Food-processing wastewater (FPWW), as opposed to solid residues, occurs extensively throughout the world, and has considerable potential for resource recovery (RR), however, at present, it is severely underutilized. This paper serves as a suggested ‘plan forward’ to optimize integrated RR from FPWW. In order to optimize this potential and ‘close the loop’, there needs to be further development in ...
- DOI:
- 10.1016/j.copbio.2022.102735
- https://doi.org/10.1016/j.copbio.2022.102735
- Author:
- Alexander F Chin; Jennifer H Elisseeff
- Source:
- Current opinion in biotechnology 2022 v.76 pp. 102737
- ISSN:
- 0958-1669
- Subject:
- adults; biocompatible materials; biotechnology; cell cycle checkpoints; humans; therapeutics; tissue repair
- Abstract:
- ... Tissue engineers have long worked to develop cells, biomaterial matrices, and signaling molecules designed to restore or promote the repair of lost or damaged tissue. Senescent cells (SnCs), that is, cells that have entered permanent cell-cycle arrest, exert powerful cell non-autonomous effects on their local environments. As such, SnCs influence cell fates and pathologies in adult tissue, includi ...
- DOI:
- 10.1016/j.copbio.2022.102737
- https://doi.org/10.1016/j.copbio.2022.102737
- Author:
- Lihao Fu; Erpeng Guo; Jianzhi Zhang; Keyi Li; Yongcan Chen; Tong Si
- Source:
- Current opinion in biotechnology 2022 v.76 pp. 102725
- ISSN:
- 0958-1669
- Subject:
- biotechnology; feedstocks; instrumentation; mass spectrometry; robots
- Abstract:
- ... Microbial cell factories convert renewable feedstocks into desirable chemicals and materials. Due to the lack of predictive modeling, high-throughput screening remains essential for microbial strain engineering. Mass spectrometry (MS) is a label-free modality with superior sensitivity and chemical specificity. Critical advances in improving the throughput of MS assays on complex microbial samples ...
- DOI:
- 10.1016/j.copbio.2022.102725
- https://doi.org/10.1016/j.copbio.2022.102725
- Author:
- Fausto Artico; Arthur L Edge III; Kyle Langham
- Source:
- Current opinion in biotechnology 2022 v.76 pp. 102714
- ISSN:
- 0958-1669
- Subject:
- artificial intelligence; biotechnology; computer software; industry; information technology; infrastructure; landscapes; markets
- Abstract:
- ... Recent Industry 4.0 advancements are making available massive amounts of data for the development of innovative BioTech solutions. However, several challenges need to be overcome to correctly use data and novel, non-pharma technologies to greatly speed up discovery, optimization and market delivery of products, and services. In this review, we bring your attention to the important aspects of Big D ...
- DOI:
- 10.1016/j.copbio.2022.102714
- https://doi.org/10.1016/j.copbio.2022.102714
- Author:
- Luis Rojo; Luis García-Fernández; María Rosa Aguilar; Blanca Vázquez-Lasa
- Source:
- Current opinion in biotechnology 2022 v.76 pp. 102752
- ISSN:
- 0958-1669
- Subject:
- antibiotic resistance; antiseptics; biocides; biocompatible materials; biomimetics; pathogens; polymers; quality of life
- Abstract:
- ... Antimicrobial resistance is the main threat to biomaterial failure with a huge impact on National Health Systems and patients’ quality of life. Materials engineering and biotechnology have experienced great advances and have converged in the development of new and more sophisticated biomimetic systems with antimicrobial properties. In this sense, polymeric biomaterials play and will play a key rol ...
- DOI:
- 10.1016/j.copbio.2022.102752
- https://doi.org/10.1016/j.copbio.2022.102752
- Author:
- Tim Hülsen; Andrew C Barnes; Damien J Batstone; Gabriel Capson-Tojo
- Source:
- Current opinion in biotechnology 2022 v.76 pp. 102726
- ISSN:
- 0958-1669
- Subject:
- biomass; capital; economic feasibility; lighting; microalgae; mixed culture; photobioreactors; polyhydroxyalkanoates; protein content; protein synthesis; single cell protein; value added; wastewater
- Abstract:
- ... Mixed culture purple phototrophic bacteria (PPB) is a rapidly emerging technology for resource recovery from wastewaters. PPB biomass can be used as single-cell protein, with a high protein content complemented by value-added components (e.g. pigments and polyhydroxyalkanoates), merging functionalities within a single product. This has the potential to increase the value and impact the economic fe ...
- DOI:
- 10.1016/j.copbio.2022.102726
- https://doi.org/10.1016/j.copbio.2022.102726