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- Liu, Hualan; Deutschbauer, Adam M
- Current opinion in biotechnology 2018 v.51 pp. 116-122
- Bacillus subtilis; Escherichia coli; bacteria; hosts; metabolic engineering; microbiome; models; researchers; technology
- ... The paradigm of large research communities collectively working on a small number of model bacteria such as Escherichia coli and Bacillus subtilis is changing. While these classic model bacteria will continue to be important for advanced systems biology and new technology development, we envision that increasingly small research teams will be deeply investigating their own favorite strains, for ex ...
- Mougiakos, Ioannis; Bosma, Elleke F; Ganguly, Joyshree; van der Oost, John; van Kranenburg, Richard
- Current opinion in biotechnology 2018 v.50 pp. 146-157
- Bacilli; Clostridia; Cyanobacteria; DNA; Escherichia coli; RNA; bacteria; genetic engineering; hosts; metabolic engineering; models
- ... High engineering efficiencies are required for industrial strain development. Due to its user-friendliness and its stringency, CRISPR-Cas-based technologies have strongly increased genome engineering efficiencies in bacteria. This has enabled more rapid metabolic engineering of both the model host Escherichia coli and non-model organisms like Clostridia, Bacilli, Streptomycetes and cyanobacteria, ...