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- Notebaart, Richard A; Kintses, Bálint; Feist, Adam M; Papp, Balázs
- Current opinion in biotechnology 2018 v.49 pp. 108-114
- biochemical pathways; biotechnology; enzymes; evolutionary adaptation; metabolism; models; phenotype
- ... A key challenge in molecular systems biology is understanding how new pathways arise during evolution and how to exploit them for biotechnological applications. New pathways in metabolic networks often evolve by recruiting weak promiscuous activities of pre-existing enzymes. Here we describe recent systems biology advances to map such ‘underground’ activities and to predict and analyze their contr ...