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You searched for: Journal name Current opinion in microbiology Remove constraint Journal name: Current opinion in microbiology Publication year rev 7978-2022 Remove constraint Publication year rev: 7978-2022 Source 2022 v.67 Remove constraint Source: 2022 v.67
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1. Archaeal key-residents within the human microbiome: characteristics, interactions and involvement in health and disease

Author:
Rokhsareh Mohammadzadeh; Alexander Mahnert; Stefanie Duller; Christine Moissl-Eichinger
Source:
Current opinion in microbiology 2022 v.67 pp. 102146
ISSN:
1369-5274
Subject:
Methanobrevibacter; Thaumarchaeota; humans; microbiome; pathogens
Abstract:
... Since the introduction of Archaea as new domain of life more than 40 years ago, they are no longer regarded as eccentric inhabitants of extreme ecosystems. These microorganisms are widespread in various moderate ecosystems, including eukaryotic hosts such as humans. Indeed, members of the archaeal community are now recognized as paramount constituents of human microbiome, while their definite role ...
DOI:
10.1016/j.mib.2022.102146

2. Assembly of the exosporium layer in Clostridioides difficile spores

Author:
Daniel Paredes-Sabja; Francisca Cid-Rojas; Marjorie Pizarro-Guajardo
Source:
Current opinion in microbiology 2022 v.67 pp. 102137
ISSN:
1369-5274
Subject:
Clostridium difficile; exine; health services; microbiology; morphogenesis; morphs; relapse; spores
Abstract:
... Clostridioides difficile is a Gram-positive, spore-forming obligate anaerobe and a major threat to the healthcare system world-wide. Because of its strict anaerobic requirements, the infectious and transmissible morphotype is the dormant spore. During infection, C. difficile produces spores that can persist in the host and are responsible for disease recurrence and transmission, especially between ...
DOI:
10.1016/j.mib.2022.01.008

3. Recent advances in applying cell-free systems for high-value and complex natural product biosynthesis

Author:
Xiangyang Ji; Wan-Qiu Liu; Jian Li
Source:
Current opinion in microbiology 2022 v.67 pp. 102142
ISSN:
1369-5274
Subject:
biosynthesis; enzymes; microbiology; toxicity
Abstract:
... Natural products have complex chemical structures and exhibit diverse bioactivities. To harness these high-value natural compounds, robust approaches are required for their rapid and sustainable production. Recently, cell-free systems as one promising solution have been applied to produce natural products by reconstitution of their entire biosynthetic pathways in vitro. Here, we highlight recent a ...
DOI:
10.1016/j.mib.2022.102142

4. Engineering synthetic spatial patterns in microbial populations and communities

Author:
Içvara Barbier; Hadiastri Kusumawardhani; Yolanda Schaerli
Source:
Current opinion in microbiology 2022 v.67 pp. 102149
ISSN:
1369-5274
Subject:
attitudes and opinions; diagnostic techniques; engineers; microbial communities; microorganisms; synthetic biology
Abstract:
... Spatial pattern formation is an important feature of almost all biological systems. Thanks to the advances in synthetic biology, we can engineer microbial populations and communities to display sophisticated spatial patterns. This bottom-up approach can be used to elucidate the general principles underlying pattern formation. Moreover, it is of interest for a plethora of applications, from the pro ...
DOI:
10.1016/j.mib.2022.102149

5. Glycan processing in gut microbiomes

Author:
Sabina Leanti La Rosa; Matthew P Ostrowski; Arturo Vera-Ponce de León; Lauren S McKee; Johan Larsbrink; Vincent G Eijsink; Elisabeth C Lowe; Eric C Martens; Phillip B Pope
Source:
Current opinion in microbiology 2022 v.67 pp. 102143
ISSN:
1369-5274
Subject:
animal growth; diet; digestive tract; food webs; gastrointestinal system; habitats; microbiology; microbiome; mucus; polysaccharides
Abstract:
... Microbiomes and their enzymes process many of the nutrients accessible in the gastrointestinal tract of bilaterians and play an essential role in host health and nutrition. In this review, we describe recent insights into nutrient processing in microbiomes across three exemplary yet contrasting gastrointestinal ecosystems (humans, ruminants and insects), with focus on bacterial mechanisms for the ...
DOI:
10.1016/j.mib.2022.102143

6. Natural selection on crosstalk between gene regulatory networks facilitates bacterial adaptation to novel environments

Author:
Tiffany B Taylor; Matthew J Shepherd; Robert W Jackson; Mark W Silby
Source:
Current opinion in microbiology 2022 v.67 pp. 102140
ISSN:
1369-5274
Subject:
gene regulatory networks; genes; microbiology; mutation; natural selection; raw materials
Abstract:
... At the level of the gene, mutation is the raw material for natural selection. However, at the level of the gene regulatory network (GRN), variation is revealed to selection via promiscuous regulator activity (‘crosstalk’), which creates opportunities for genetic innovation that can facilitate adaptation. Many genetic and environmental features can contribute to increasing potential for crosstalk b ...
DOI:
10.1016/j.mib.2022.02.002

7. Strain wars and the evolution of opportunistic pathogens

Author:
Samuel K Sheppard
Source:
Current opinion in microbiology 2022 v.67 pp. 102138
ISSN:
1369-5274
Subject:
environmental impact; genetic variation; pathogens; secondary infection; virulence
Abstract:
... Bacteria live in complex communities with multiple species and strains competing with each other. Victories and defeats within these microbial wars are largely ignored unless they have a noticeable impact on the environment or the host, for example when a disease causing strain emerges as a winner. Evolutionary theory typically explains pathogen emergence as a trade-off between virulence and trans ...
DOI:
10.1016/j.mib.2022.01.009

8. Deciphering mechanisms and implications of bacterial translocation in human health and disease

Author:
Shen Jin; Daniela Wetzel; Melanie Schirmer
Source:
Current opinion in microbiology 2022 v.67 pp. 102147
ISSN:
1369-5274
Subject:
colorectal neoplasms; human health; inflammatory bowel disease; liver cirrhosis; microbiology; rheumatoid arthritis
Abstract:
... Significant increases in potential microbial translocation, especially along the oral–gut axis, have been identified in many immune-related and inflammatory diseases, such as inflammatory bowel disease, colorectal cancer, rheumatoid arthritis, and liver cirrhosis, for which we currently have no cure or long-term treatment options. Recent advances in computational and experimental omics approaches ...
DOI:
10.1016/j.mib.2022.102147

9. Ecological drivers of division of labour in Streptomyces

Author:
Matthew F Traxler; Daniel E Rozen
Source:
Current opinion in microbiology 2022 v.67 pp. 102148
ISSN:
1369-5274
Subject:
Streptomyces; antibiotics; labor; phenotype; social class; spores
Abstract:
... Division of labour occurs when different individuals, cells or tissues become specialised to perform complementary tasks that benefit the whole organism or social group. Although long studied in multicellular organisms and colonies of social insects, several recent studies have established that division of labour is common in microorganisms. We review recent work on the division of labour in unice ...
DOI:
10.1016/j.mib.2022.102148

10. Employing methylotrophs for a green economy: one-carbon to fuel them all and through metabolism redesign them

Author:
Alekhya Govindaraju; Nathan M Good; Alexa M Zytnick; Norma Cecilia Martinez-Gomez
Source:
Current opinion in microbiology 2022 v.67 pp. 102145
ISSN:
1369-5274
Subject:
economic sustainability; energy; metabolism; microbiology; pollution; wastes
Abstract:
... Microbial platforms are currently being optimized to revolutionize industrial energy production while mitigating shortages of global resources and food supplies. Here, we address recent advances to develop bacterial methylotrophic platforms as promising platforms enabling the reuse of products and materials (at their highest value) while reducing waste and pollution. ...
DOI:
10.1016/j.mib.2022.102145

11. Selective drivers of simple multicellularity

Author:
Kai Tong; G Ozan Bozdag; William C Ratcliff
Source:
Current opinion in microbiology 2022 v.67 pp. 102141
ISSN:
1369-5274
Subject:
directed evolution; microbiology; paleontology; surveys; synthetic biology
Abstract:
... In order to understand the evolution of multicellularity, we must understand how and why selection favors the first steps in this process: the evolution of simple multicellular groups. Multicellularity has evolved many times in independent lineages with fundamentally different ecologies, yet no work has yet systematically examined these diverse selective drivers. Here we review recent developments ...
DOI:
10.1016/j.mib.2022.102141