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- Gruber, Stephan
- Current opinion in microbiology 2018 v.42 pp. 96-103
- DNA; DNA damage; DNA replication; bacteria; cell viability; chromosome segregation; chromosome translocation; chromosomes; genome; transcription (genetics)
- ... Bacteria transcribe, duplicate and segregate their genomes all at once. Conflicts between DNA replication and active transcription are a major source of DNA damage and jeopardize genome integrity and cell survival. Co-orientation of replication forks and transcription units is thought to reduce the impact of such conflicts. Like transcription and replication, chromosome segregation relies on the t ...