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- Neville, B Anne; Forster, Samuel C; Lawley, Trevor D
- Current opinion in microbiology 2018 v.42 pp. 47-52
- algorithms; anaerobes; bacteria; bioinformatics; digestive system; health promotion; high-throughput nucleotide sequencing; humans; intestinal microorganisms; microbiome; new species; phenotype; pipelines; plate count
- ... Advances in high-throughput sequencing technologies and the development of sophisticated bioinformatics analysis methods, algorithms, and pipelines to handle the large amounts of data generated have driven the field of human microbiome research forward. This specialist knowledge has been crucial to thoroughly mine the human gut microbiota, particularly in the absence of methods for the routine cul ...
- Wolf, Thomas; Kämmer, Philipp; Brunke, Sascha; Linde, Jörg
- Current opinion in microbiology 2018 v.42 pp. 7-12
- bioinformatics; genes; high-throughput nucleotide sequencing; host-pathogen relationships; non-coding RNA; prediction; receptors; ribosomal RNA; symbiosis
- ... Organisms do not exist isolated from each other, but constantly interact. Cells can sense the presence of interaction partners by a range of receptors and, via complex regulatory networks, specifically react by changing the expression of many of their genes. Technological advances in next-generation sequencing over the recent years now allow us to apply RNA sequencing to two species at the same ti ...