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- Gamba, Pamela; Zenkin, Nikolay
- Current opinion in microbiology 2018 v.42 pp. 13-18
- DNA-directed RNA polymerase; RNA; active sites; gene expression; in vivo studies; nucleosides; transcription (genetics)
- ... Accuracy of transcription is essential for productive gene expression, and the past decade has brought new understanding of the mechanisms ensuring transcription fidelity. The discovery of a new catalytic domain, the Trigger Loop, revealed that RNA polymerase can actively choose the correct substrates. Also, the intrinsic proofreading activity was found to proceed via a ribozyme-like mechanism, wh ...
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