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You searched for: Journal name Developmental and comparative immunology Remove constraint Journal name: Developmental and comparative immunology Publication year rev 7985-2015 Remove constraint Publication year rev: 7985-2015
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1. IL- 17 signaling components in bivalves: Comparative sequence analysis and involvement in the immune responses

Author:
Umberto Rosani; Laura Varotto; Marco Gerdol; Alberto Pallavicini; Paola Venier
Source:
Developmental and comparative immunology 2015 v.52 no.2 pp. 255-268
ISSN:
0145-305X
Subject:
Chordata; Crassostrea gigas; Mytilus galloprovincialis; amino acids; bacteria; data collection; gene expression; genome; gills; hemocytes; high-throughput nucleotide sequencing; humans; immune response; interleukin-17; ligands; models; mussels; oysters; quantitative polymerase chain reaction; receptors; signal transduction; transcriptome
Abstract:
... The recent discovery of soluble immune-regulatory molecules in invertebrates takes advantage of the rapid growth of next generation sequencing datasets. Following protein domain searches in the transcriptomes of 31 bivalve spp. and in few available mollusk genomes, we retrieved 59 domains uniquely identifying interleukin 17 (IL-17) and 96 SEFIR domains typical of IL-17 receptors and CIKS/ACT1 prot ...
DOI:
10.1016/j.dci.2015.05.001

2. Acute cold stress improved the transcription of pro-inflammatory cytokines of Chinese soft-shelled turtle against Aeromonas hydrophila

Author:
Zuobing Zhang; Bojian Chen; Lin Yuan; Cuijuan Niu
Source:
Developmental and comparative immunology 2015 v.49 no.1 pp. 127-137
ISSN:
0145-305X
Subject:
Aeromonas hydrophila; Pelodiscus sinensis; bioinformatics; cold stress; death; gene expression; interleukin-1beta; interleukin-6; interleukin-8; intestines; messenger RNA; quantitative polymerase chain reaction; spleen; temperature; tumor necrosis factor-alpha; turtles; South East Asia
Abstract:
... Chinese soft-shelled turtle, Pelodiscus sinensis, is widely cultured in East and Southeast Asian countries. It frequently encounters the stress of abrupt temperature changes, which leads to mass death in most cases. However, the mechanism underlying the stress-elicited death remains unknown. We have suspected that the stress impaired the immune function of Chinese soft-shelled turtle, which could ...
DOI:
10.1016/j.dci.2014.10.010

3. Amphioxus as a model for investigating evolution of the vertebrate immune system

Author:
Shaochun Yuan; Jie Ruan; Shengfeng Huang; Shangwu Chen; Anlong Xu
Source:
Developmental and comparative immunology 2015 v.48 no.2 pp. 297-305
ISSN:
0145-305X
Subject:
Chordata; adaptive immunity; genes; innate immunity; lymphocytes; microorganisms; models; phylogeny; receptors
Abstract:
... As the most basal chordate, the cephalochordate amphioxus has unique features that make it a valuable model for understanding the phylogeny of immunity. Vertebrate adaptive immunity (VAI) mediated by lymphocytes bearing variable receptors has been well-studied in mammals but not observed in invertebrates. However, the identification of lymphocyte-like cells in the gill along with genes related wit ...
DOI:
10.1016/j.dci.2014.05.004

4. Analysis on the expression and function of syndecan in the Pacific white shrimp Litopenaeus vannamei

Author:
Hui Yang; Shihao Li; Fuhua Li; Rong Wen; Jianhai Xiang
Source:
Developmental and comparative immunology 2015 v.51 no.2 pp. 278-286
ISSN:
0145-305X
Subject:
Litopenaeus vannamei; White spot syndrome virus; amino acids; bioinformatics; cell adhesion; cell membranes; complementary DNA; cytoskeleton; gene expression regulation; hemocytes; immunity; immunocytochemistry; mortality; open reading frames; polyclonal antibodies; proteins; rabbits; shrimp; small interfering RNA
Abstract:
... Syndecan is considered to be a multifunctional protein which functions as a cell surface receptor involved in cell adhesion, migration, cytoskeleton organization and differentiation. Previous bioinformatic analysis has revealed that syndecan in shrimp might interact with white spot syndrome virus (WSSV). In the present study, we experimentally studied the function of syndecan in shrimp immunity. T ...
DOI:
10.1016/j.dci.2015.03.013

5. Antimicrobial peptides in echinoderm host defense

Author:
Chun Li; Hans-Matti Blencke; Tor Haug; Klara Stensvåg
Source:
Developmental and comparative immunology 2015 v.49 no.1 pp. 190-197
ISSN:
0145-305X
Subject:
Echinoidea; adults; anti-infective properties; antimicrobial peptides; cysteine; innate immunity; larvae; lectins; marine environment; tryptophan
Abstract:
... Antimicrobial peptides (AMPs) are important effector molecules in innate immunity. Here we briefly summarize characteristic traits of AMPs and their mechanisms of antimicrobial activity. Echinoderms live in a microbe-rich marine environment and are known to express a wide range of AMPs. We address two novel AMP families from coelomocytes of sea urchins: cysteine-rich AMPs (strongylocins) and heter ...
DOI:
10.1016/j.dci.2014.11.002

6. B cell signatures of BCWD-resistant and susceptible lines of rainbow trout: A shift towards more EBF-expressing progenitors and fewer mature B cells in resistant animals

Author:
Patty Zwollo; Jocelyn C. Ray; Michael Sestito; Elizabeth Kiernan; Gregory D. Wiens; Steve Kaattari; Brittany StJacques; Lidia Epp
Source:
Developmental and comparative immunology 2015 v.48 no.1 pp. 1-12
ISSN:
0145-305X
Subject:
Flavobacterium psychrophilum; Gram-negative bacteria; Oncorhynchus mykiss; antibodies; bacterial cold-water disease; cell culture; chronic diseases; disease resistance; flow cytometry; gene expression regulation; genetic disorders; genetic lines; immune response; immunoglobulin heavy chains; interleukin-1beta; kidneys; pathogens; phenotype; spleen; transcription factors; trout
Abstract:
... Bacterial cold water disease (BCWD) is a chronic disease of rainbow trout, and is caused by the Gram-negative bacterium Flavobacterium psychrophilum (Fp), a common aquaculture pathogen. The National Center for Cool and Cold Water Aquaculture has bred two genetic lines of rainbow trout: a line of Fp-resistant trout (ARS-Fp-R or R-line trout) and a line of susceptible trout (ARS-Fp-S, or S-line). Li ...
DOI:
10.1016/j.dci.2014.07.018
CHORUS:
10.1016/j.dci.2014.07.018
Chorus Open Access:
10.1016/j.dci.2014.07.018

7. Bacterial and viral induction of chicken thrombocyte inflammatory responses

Author:
F. Ferdous; T. Scott
Source:
Developmental and comparative immunology 2015 v.49 no.2 pp. 225-230
ISSN:
0145-305X
Subject:
Toll-like receptors; blood platelets; chickens; culture media; gene expression; gene expression regulation; genes; inducible nitric oxide synthase; inflammation; interleukin-6; ligands; lipopolysaccharides; lipoteichoic acids; macrophages; nitric oxide; oligodeoxyribonucleotides; pathogens; polyinosinic-polycytidylic acid; thymidine
Abstract:
... Thrombocytes express Toll-like receptors (TLRs) that detect bacterial or viral pathogens to signal the release of cytokines and mediators. We examined inflammatory responses when thrombocytes were exposed to four TLR ligands. Treatment of thrombocytes with TLR ligands demonstrates differential effects on gene expression of interleukin (IL)-6. Among the TLR ligands examined, lipopolysaccharide stim ...
DOI:
10.1016/j.dci.2014.11.019

8. The Black cells phenotype is caused by a point mutation in the Drosophila pro-phenoloxidase 1 gene that triggers melanization and hematopoietic defects1Equal contribution.1

Author:
Claudine Neyen; Olivier Binggeli; Pietro Roversi; Lise Bertin; Maroun Bou Sleiman; Bruno Lemaitre
Source:
Developmental and comparative immunology 2015 v.50 no.2 pp. 166-174
ISSN:
0145-305X
Subject:
Drosophila; alanine; catalytic activity; enzymes; hemocytes; innate immunity; loss-of-function mutation; melanin; melanization; mutants; parasites; phenotype; point mutation; prophenoloxidase; proteolysis; reactive oxygen species; transgenes; valine
Abstract:
... Melanization contributes to arthropod-specific innate immunity through deposition of melanin at wound sites or around parasites, with concomitant release of microbicidal reactive oxygen species. Melanization requires sequential activation of proteolytic enzymes in the hemolymph, including the final enzyme pro-phenoloxidase. Black cells (Bc) is a mutation causing spontaneous melanization of Drosoph ...
DOI:
10.1016/j.dci.2014.12.011

9. Botryllus schlosseri allorecognition: tackling the enigma

Author:
Daryl A. Taketa; Anthony W. De Tomaso
Source:
Developmental and comparative immunology 2015 v.48 no.1 pp. 254-265
ISSN:
0145-305X
Subject:
Botryllus schlosseri; adaptive immunity; immune response; loci; major histocompatibility complex; vertebrates
Abstract:
... Allorecognition has been well-studied in the context of vertebrate adaptive immunity and recognition of the Major Histocompatibility Complex (MHC), which is the central event of vertebrate immune responses. Although allorecognition systems have been identified throughout the metazoa, recent results have shown that there is no apparent conservation or orthologous relationship between the mechanisms ...
DOI:
10.1016/j.dci.2014.03.014
PubMed:
24709050
PubMed Central:
PMC4185259

10. Burkholderia gut symbionts enhance the innate immunity of host Riptortus pedestris

Author:
Jiyeun Kate Kim; Jun Beom Lee; Ye Rang Huh; Ho Am Jang; Chan-Hee Kim; Jin Wook Yoo; Bok Luel Lee
Source:
Developmental and comparative immunology 2015 v.53 no.1 pp. 265-269
ISSN:
0145-305X
Subject:
Burkholderia; Riptortus clavatus; Riptortus pedestris; animal models; anti-infective properties; antimicrobial peptides; cell-mediated immunity; digestive system; hemolymph; humoral immunity; innate immunity; insects; symbionts; symbiosis
Abstract:
... The relation between gut symbiosis and immunity has been reported in various animal model studies. Here, we corroborate the effect of gut symbiont to host immunity using the bean bug model. The bean bug, Riptortus pedestris, is a useful gut symbiosis model due to the monospecific gut symbiont, genus Burkholderia. To examine the effect of gut symbiosis to host immunity, we generated the gut symbion ...
DOI:
10.1016/j.dci.2015.07.006

11. CD83 is required for the induction of protective immunity by a DNA vaccine in a teleost model

Author:
Mo-fei Li; Yong-xin Li; Li Sun
Source:
Developmental and comparative immunology 2015 v.51 no.1 pp. 141-147
ISSN:
0145-305X
Subject:
Scophthalmus maximus; antibodies; antibody formation; blood serum; cytotoxicity; dendritic cells; gene expression; kidneys; leukocytes; lymphocyte proliferation; macrophages; models; plasmids; recombinant vaccines; turbot; virus replication
Abstract:
... In mammals, CD83 is a surface marker on mature dendritic cells and vital to lymphocyte activation. In teleost, studies on the function of CD83 are very limited. In this study, we examined the potential involvement of turbot (Scophthalmus maximus) CD83, SmCD83, in vaccine-induced immunity. For this purpose, turbot were immunized with pORF75, a DNA vaccine against megalocytivirus, in the presence or ...
DOI:
10.1016/j.dci.2015.03.005

12. Carp thrombocyte phagocytosis requires activation factors secreted from other leukocytes

Author:
Takahiro Nagasawa; Tomonori Somamoto; Miki Nakao
Source:
Developmental and comparative immunology 2015 v.52 no.2 pp. 107-111
ISSN:
0145-305X
Subject:
Cyprinus carpio; blood platelets; carp; inflammation; leukocytes; phagocytosis; tissue repair
Abstract:
... Thrombocytes are nucleated blood cells in non-mammalian vertebrates, which were recently focused on not only as hemostatic cells but also as immune cells with potent phagocytic activities. We have analyzed the phagocytic activation mechanisms in common carp (Cyprinus carpio) thrombocytes. MACS-sorted mAb+ thrombocytes showed no phagocytic activity even in the presence of several stimulants. Howeve ...
DOI:
10.1016/j.dci.2015.05.002

13. Cell type-specific differences in β-glucan recognition and signalling in porcine innate immune cells

Author:
Kim Baert; Eva Sonck; Bruno M. Goddeeris; Bert Devriendt; Eric Cox
Source:
Developmental and comparative immunology 2015 v.48 no.1 pp. 192-203
ISSN:
0145-305X
Subject:
beta-glucans; cytokines; immune response; macrophage-1 antigen; macrophages; mice; models; neutrophils; non-specific protein-tyrosine kinase; phagocytosis; receptors; secretion; swine
Abstract:
... β-glucans exert receptor-mediated immunomodulating activities, including oxidative burst activity and cytokine secretion. The role of the β-glucan receptors dectin-1 and complement receptor 3 (CR3) in the response of immune cells towards β-glucans is still unresolved. Dectin-1 is considered as the main β-glucan receptor in mice, while recent studies in man show that CR3 is more important in β-gluc ...
DOI:
10.1016/j.dci.2014.10.005

14. CgIL17-5, an ancient inflammatory cytokine in Crassostrea gigas exhibiting the heterogeneity functions compared with vertebrate interleukin17 molecules

Author:
Lusheng Xin; Huan Zhang; Ran Zhang; Hui Li; Weilin Wang; Lingling Wang; Hao Wang; Limei Qiu; Linsheng Song
Source:
Developmental and comparative immunology 2015 v.53 no.2 pp. 339-348
ISSN:
0145-305X
Subject:
Crassostrea gigas; Escherichia coli; Micrococcus luteus; Vibrio splendidus; bacteria; fluorescence; gene expression; gene expression regulation; genome; hemocytes; human umbilical vein endothelial cells; humans; immune response; inflammation; interleukin-17; interleukin-6; ligands; lipopolysaccharides; luciferase; messenger RNA; oysters; pathogens; peptidoglycans; screening; signal transduction; transcription factor NF-kappa B
Abstract:
... Interleukin 17 (IL17) is a proinflammatory cytokine that plays an important role in immune response. Recently, five novel IL17 homologs have been identified by screening and analyzing the genome of pacific oyster Crassostrea gigas. In the present study, the functions of CgIL17-5 were investigated by examining the distribution of its mRNA and protein, ligands binding and modulation in immune respon ...
DOI:
10.1016/j.dci.2015.08.002

15. Characterization and identification of calmodulin and calmodulin binding proteins in hemocyte of the black tiger shrimp (Penaeus monodon)

Author:
Panjana Sengprasert; Piti Amparyup; Anchalee Tassanakajorn; Ratree Wongpanya
Source:
Developmental and comparative immunology 2015 v.50 no.2 pp. 87-97
ISSN:
0145-305X
Subject:
Penaeus monodon; Vibrio harveyi; actin; amino acids; calcium; calmodulin; circular dichroism spectroscopy; complementary DNA; eukaryotic cells; fluorescence emission spectroscopy; gene silencing; genes; hemocytes; immune response; immune system; isoelectric point; messenger RNA; metabolism; open reading frames; pathogens; protein-glutamine gamma-glutamyltransferase; shrimp; tissue distribution; transcription (genetics)
Abstract:
... Calmodulin (CaM), a ubiquitous intracellular calcium (Ca2+) sensor in all eukaryotic cells, is one of the well-known signaling proteins. Previously, CaM gene has shown a high transcriptional level in hemocyte of the pathogen infected shrimp, suggesting that shrimp CaM does not only regulate Ca2+ metabolism, but is also involved in immune response cascade. In the present study, the CaM gene of shri ...
DOI:
10.1016/j.dci.2015.02.003

16. Characterization of a MAVS ortholog from the Chinese tree shrew (Tupaia belangeri chinensis)

Author:
Ling Xu; Dandan Yu; Li Peng; Yu Fan; Jiaqi Chen; Yong-Tang Zheng; Chen Wang; Yong-Gang Yao
Source:
Developmental and comparative immunology 2015 v.52 no.1 pp. 58-68
ISSN:
0145-305X
Subject:
Primates; RNA viruses; Tupaia; amino acid sequences; amino acids; animal models; caspases; complementary DNA; gene expression; genes; humans; innate immunity; interferon-beta; messenger RNA; mitochondria; mutants; phylogeny; polypeptides; quantitative polymerase chain reaction; signal transduction; transcription factor NF-kappa B
Abstract:
... Human mitochondrial antiviral signaling protein (hMAVS, also known as IPS-1, VISA, or Cardif) is essential for antiviral innate immunity. The Chinese tree shrew (Tupaia belangeri chinenses), a close relative of primates, is emerging as a potential animal model for investigating viral infection. However, there is a lack of biological knowledge about the antiviral innate immunity of the tree shrew. ...
DOI:
10.1016/j.dci.2015.04.014

17. Characterization of an inhibitor of apoptosis protein in Crassostrea gigas clarifies its role in apoptosis and immune defense

Author:
Tao Qu; Linlin Zhang; Wei Wang; Baoyu Huang; Yingxiang Li; Qihui Zhu; Li Li; Guofan Zhang
Source:
Developmental and comparative immunology 2015 v.51 no.1 pp. 74-78
ISSN:
0145-305X
Subject:
Crassostrea gigas; apoptosis; caspases; cell proliferation; complementary DNA; gene expression; genes; gills; immune response; messenger RNA; oysters; palps; phylogeny; proteins; two hybrid system techniques
Abstract:
... The inhibitor of apoptosis (IAP) proteins maintain a balance between cell proliferation and cell death by inhibiting caspase activity and facilitating immune responses. In this study, phylogenetic analysis revealed lineage-specific expansion and tandem duplication of IAPs in the Pacific oyster Crassostrea gigas. We then investigated a representative oyster-specific XIAP-like gene (CgIAP2) to under ...
DOI:
10.1016/j.dci.2015.02.011

18. Characterization of surface phenotypic molecules of teleost dendritic cells

Author:
Tong Shao; Lv-Yun Zhu; Li Nie; Wei Shi; Wei-Ren Dong; Li-Xin Xiang; Jian-Zhong Shao
Source:
Developmental and comparative immunology 2015 v.49 no.1 pp. 38-43
ISSN:
0145-305X
Subject:
CD4-positive T-lymphocytes; Danio rerio; adaptive immunity; bioactive properties; dendritic cells; fish; fluorescent antibody technique; functional properties; mammals; models; phenotype; staining
Abstract:
... Dendritic cells (DCs) are among the most important professional antigen-presenting cells (APCs) that participate in various biological activities in mammals. However, evidence of the existence of DCs in teleost fish and other lower vertebrates remains limited. In this study, phenotypic and functional characteristics of teleost DCs were described in a zebrafish model. An improved method to efficien ...
DOI:
10.1016/j.dci.2014.11.010

19. Characterization of the duplicate L-SIGN and DC-SIGN genes in miiuy croaker and evolutionary analysis of L-SIGN in fishes

Author:
Chang Shu; Shanchen Wang; Tianjun Xu
Source:
Developmental and comparative immunology 2015 v.50 no.1 pp. 19-25
ISSN:
0145-305X
Subject:
Miichthys miiuy; bacteria; calcium; cell adhesion; fish; genes; immune response; innate immunity; kidneys; lectins; liver; lymph; pathogens; receptors; sequence analysis; spleen
Abstract:
... Dendritic cell-specific ICAM-3-grabbing non-integrin (DC-SIGN/CD209) and liver/lymph node-specific ICAM-grabbing non-integrin (L-SIGN/CD299) which are homologues of DC-SIGN are important members in C-type lectin receptors family as key molecules to recognize and eliminate pathogens in the innate immune system. DC-SIGN and L-SIGN have become hot topics in recent studies which both served as cell ad ...
DOI:
10.1016/j.dci.2015.01.004
PubMed:
25596146
PubMed Central:
PMC7124703

20. Characterization of two novel ADP ribosylation factors from giant freshwater prawn Macrobrachium rosenbergii and their responses to WSSV challenge

Author:
Zheng-Feng Ding; Jie Ren; Jing-Min Tan; Zheng Wang; Shao-Wu Yin; Ying Huang; Xin Huang; Wen Wang; Jiang-Feng Lan; Qian Ren
Source:
Developmental and comparative immunology 2015 v.48 no.1 pp. 204-209
ISSN:
0145-305X
Subject:
G-proteins; Macrobrachium rosenbergii; Marsupenaeus japonicus; RNA interference; adenosine diphosphate; adenosine monophosphate; gene expression; genes; gills; heart; hepatopancreas; innate immunity; intestines; phylogeny; physiological transport; shrimp; stomach; transcription (genetics)
Abstract:
... ADP-ribosylation factors (Arfs) are small GTP-binding proteins that have an essential function in intracellular trafficking and organelle structure. To date, little information is available on the Arfs in the economically important giant freshwater prawn Macrobrachium rosenbergii and their relationship to viral infection. Here we identified two Arf genes from M. rosenbergii (MrArf1 and MrArf2) for ...
DOI:
10.1016/j.dci.2014.10.006
PubMed:
25451300
PubMed Central:
PMC7124501

21. Characterization of two regulators of the TNF-α signaling pathway in Apostichopus japonicus: LPS-induced TNF-α factor and baculoviral inhibitor of apoptosis repeat-containing 2

Author:
Xiumei Zhang; Pengjuan Zhang; Chenghua Li; Ye Li; Chunhua Jin; Weiwei Zhang
Source:
Developmental and comparative immunology 2015 v.48 no.1 pp. 138-142
ISSN:
0145-305X
Subject:
Apostichopus japonicus; RNA; Vibrio splendidus; amino acid sequences; amino acids; apoptosis; cell proliferation; complementary DNA; immune response; intestines; mammals; molecular weight; open reading frames; polypeptides; regulator genes; sequence analysis; signal transduction; tumor necrosis factor-alpha
Abstract:
... The TNF-α signaling cascade is involved in the regulation of a variety of biological processes, including cell proliferation, differentiation, apoptosis and the immune response in vertebrates. Here, two regulatory genes, lipopolysaccharide-induced tumor necrosis factor α factor (LITAF) and baculoviral inhibitor of apoptosis repeat-containing 2 (BIRC2), were identified in coelomocytes from the sea ...
DOI:
10.1016/j.dci.2014.10.001

22. Characterization of two thymosins as immune-related genes in common carp (Cyprinus carpio L.)

Author:
Zhangang Xiao; Jing Shen; Hong Feng; Hong Liu; Yaping Wang; Rong Huang; Qionglin Guo
Source:
Developmental and comparative immunology 2015 v.50 no.1 pp. 29-37
ISSN:
0145-305X
Subject:
thymosin; proteins; messenger RNA; complementary DNA; T-lymphocytes; gene overexpression; carp; early development; Cyprinus carpio; peptides; genes; immune response; Carp sprivivirus; Danio rerio; gene expression regulation
Abstract:
... Prothymosin alpha (ProTα) and thymosin beta (Tβ) belong to thymosin family, which consists of a series of highly conserved peptides involved in stimulating immune responses. ProTα b and Tβ are still poorly studied in teleost. Here, the full-length cDNAs of ProTα b and Tβ-like (Tβ-l) were cloned and identified in common carp (Cyprinus carpio L.). The expressions of carp ProTα b and Tβ-l exhibited r ...
DOI:
10.1016/j.dci.2015.01.003

23. Chemokine receptors in Atlantic salmon

Author:
Unni Grimholt; Helena Hauge; Anna Germundsson Hauge; Jong Leong; Ben F. Koop
Source:
Developmental and comparative immunology 2015 v.49 no.1 pp. 79-95
ISSN:
0145-305X
Subject:
Salmo salar; chemokine receptors; chemokines; diploidy; duplicate genes; humans; leukocytes; ligands; salmon; sequence analysis; trout
Abstract:
... Teleost sequence data have revealed that many immune genes have evolved differently when compared to other vertebrates. Thus, each gene family needs functional studies to define the biological role of individual members within major species groups. Chemokine receptors, being excellent markers for various leukocyte subpopulations, are one such example where studies are needed to decipher individual ...
DOI:
10.1016/j.dci.2014.11.009

24. Chicken CD300a homolog is found on B lymphocytes, various leukocytes populations and binds to phospholipids

Author:
Beatrice Sperling; Birgit C. Viertlboeck; Thomas W. Göbel
Source:
Developmental and comparative immunology 2015 v.50 no.2 pp. 121-128
ISSN:
0145-305X
Subject:
B-lymphocytes; T-lymphocytes; chickens; fluorescent antibody technique; genes; heterophils; ligands; macrophages; monoclonal antibodies; monocytes; natural killer cells; phosphatidylethanolamines; phosphatidylserines; spleen; thymus gland
Abstract:
... The chicken CD300 cluster contains three genes that encode inhibitory, activating and soluble forms. In the present study, we have generated a monoclonal antibody against the inhibitory CD300L-B1 molecule. The mab 1D4 was specific for the CD300L-B1 form and showed no crossreactivity with the related CD300L-X1. Virtually all bursal cells expressed CD300L-B1, whereas only a small positive subset was ...
DOI:
10.1016/j.dci.2015.02.004

25. Ciona intestinalis interleukin 17-like genes expression is upregulated by LPS challenge

Author:
Aiti Vizzini; Felicia Di Falco; Daniela Parrinello; Maria Antonietta Sanfratello; Claudia Mazzarella; Nicolò Parrinello; Matteo Cammarata
Source:
Developmental and comparative immunology 2015 v.48 no.1 pp. 129-137
ISSN:
0145-305X
Subject:
Ciona intestinalis; bacteria; chemokines; gene expression; gene expression regulation; genes; granulocytes; hemocytes; humans; in situ hybridization; inflammation; interleukin-17; models; pharynx; phylogeny; quantitative polymerase chain reaction
Abstract:
... In humans, IL-17 is a proinflammatory cytokine that plays a key role in the clearance of extracellular bacteria promoting cell infiltration and production of several cytokines and chemokines. Here, we report on three Ciona intestinalis IL-17 homologues (CiIL17-1, CiIL17-2, CiIL17-3). The gene organization, phylogenetic tree and modeling supported the close relationship with the mammalian IL-17A an ...
DOI:
10.1016/j.dci.2014.09.014

26. Cloning and characterization of two lipopolysaccharide-binding protein/bactericidal permeability–increasing protein (LBP/BPI) genes from the sea cucumber Apostichopus japonicus with diversified function in modulating ROS production

Author:
Yina Shao; Chenghua Li; Zhongjie Che; Pengjuan Zhang; Weiwei Zhang; Xuemei Duan; Ye Li
Source:
Developmental and comparative immunology 2015 v.52 no.1 pp. 88-97
ISSN:
0145-305X
Subject:
Apostichopus japonicus; Gram-negative bacteria; amino acids; complementary DNA; gene expression; genes; immune response; invertebrates; messenger RNA; protein secretion; signal peptide
Abstract:
... Lipopolysaccharide-binding protein and bactericidal permeability–increasing protein (LBP/BPI) play crucial role in modulating cellular signals in response to Gram-negative bacteria infection. In the present study, two isoforms of LBP/BPI genes (designated as AjLBP/BPI1 and AjLBP/BPI2, respectively) were cloned from the sea cucumber Apostichopus japonicus by RACE approach. The full-length cDNAs of ...
DOI:
10.1016/j.dci.2015.04.015

27. Cloning and primary immunological study of TGF-β1 and its receptors TβR I /TβR II in tilapia(Oreochromis niloticus)

Author:
Xu-liang Zhan; Tai-yang Ma; Jin-ying Wu; Li-yuan Yi; Jing-yuan Wang; Xiao-ke Gao; Wen-sheng Li
Source:
Developmental and comparative immunology 2015 v.51 no.1 pp. 134-140
ISSN:
0145-305X
Subject:
Oreochromis niloticus; Streptococcus agalactiae; apoptosis; cell movement; cell proliferation; complementary DNA; gene expression; genes; heart; kidneys; leukocytes; lipopolysaccharides; liver; messenger RNA; morphogenesis; receptors; spleen; tissue distribution; transforming growth factor beta 1
Abstract:
... The transforming growth factor β (TGF-β) superfamily plays critical roles in tumor suppression, cell proliferation and differentiation, tissue morphogenesis, lineage determination, cell migration and apoptosis. Recently, TGF-β1, one important member of TGF-β superfamily, is suggested as an immune regulator in the teleost. In this study, we cloned the cDNAs of TGF-β1 and its receptors, TβR I and Tβ ...
DOI:
10.1016/j.dci.2015.03.008

28. Comparative analysis of two types of CXCL8 from Japanese flounder (Paralichthys olivaceus)

Author:
Beibei Zhao; Takayuki Katagiri; Hidehiro Kondo; Ikuo Hirono
Source:
Developmental and comparative immunology 2015 v.52 no.1 pp. 37-47
ISSN:
0145-305X
Subject:
Paralichthys olivaceus; amino acid sequences; bacterial infections; chemotaxis; flounder; gene expression; genes; gills; immune response; immunoglobulin M; inflammation; interleukin-6; interleukin-8; kidneys; liver; messenger RNA; plasmids; spleen; staining
Abstract:
... A new type of CXCL8, named CXCL8_L1b, was identified in this research. Comparison of amino acid sequences of Japanese flounder CXCL8_L1b and CXCL8_L1a (BAB86884.1) showed only 41.2% identity. Transcripts of CXCL8_L1a were highly detected in spleen, kidney, gill and liver, while transcripts of CXCL8_L1b only were detected highly in spleen and kidney of apparently healthy fish. In fish challenged wi ...
DOI:
10.1016/j.dci.2015.04.011

29. Complement factor I from flatfish half-smooth tongue (Cynoglossus semilaevis) exhibited anti-microbial activities

Author:
Jinsong Xiang; Xihong Li; Yadong Chen; Yang Lu; Mengjun Yu; Xuejie Chen; Wenting Zhang; Yan Zeng; Luming Sun; Songlin Chen; Zhenxia Sha
Source:
Developmental and comparative immunology 2015 v.53 no.1 pp. 199-209
ISSN:
0145-305X
Subject:
Chondrichthyes; Cynoglossus semilaevis; Escherichia coli; Gram-negative bacteria; Gram-positive bacteria; Pseudomonas aeruginosa; Shewanella putrefaciens; Staphylococcus aureus; Vibrio anguillarum; active sites; amino acids; antibacterial properties; blood; complement; complementary DNA; gene expression; genes; immunity; intestines; isoelectric point; kidneys; liver; messenger RNA; molecular weight; open reading frames; phylogeny; polypeptides; proteins; quantitative analysis; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; sequence alignment; serine proteinases; signal peptide; spleen; stomach; vertebrates
Abstract:
... Complement factor I (Cfi) is a soluble serine protease which plays a crucial role in the modulation of complement cascades. In the presence of substrate modulating cofactors (such as complement factor H, C4bp, CR1, etc), Cfi cleaves and inactivates C3b and C4b, thereby controlling the complement-mediated processes. In this study, we sequenced and characterized Cfi gene from Cynoglossus Semilaevis ...
DOI:
10.1016/j.dci.2015.06.010

30. Complement regulatory protein genes in channel catfish and their involvement in disease defense response

Author:
Chen Jiang; Jiaren Zhang; Jun Yao; Shikai Liu; Yun Li; Lin Song; Chao Li; Xiaozhu Wang; Zhanjiang Liu
Source:
Developmental and comparative immunology 2015 v.53 no.1 pp. 33-41
ISSN:
0145-305X
Subject:
Edwardsiella ictaluri; Flavobacterium columnare; Ictalurus punctatus; bacterial infections; complement; gene expression regulation; genes; immune response; innate immunity; pathogens; phylogeny; regulatory proteins
Abstract:
... Complement system is one of the most important defense systems of innate immunity, which plays a crucial role in disease defense responses in channel catfish. However, inappropriate and excessive complement activation could lead to potential damage to the host cells. Therefore the complement system is controlled by a set of complement regulatory proteins to allow normal defensive functions, but pr ...
DOI:
10.1016/j.dci.2015.06.002

31. Comprehensive identification and profiling of host miRNAs in response to Singapore grouper iridovirus (SGIV) infection in grouper (Epinephelus coioides)

Author:
Chuanyu Guo; Huachun Cui; Songwei Ni; Yang Yan; Qiwei Qin
Source:
Developmental and comparative immunology 2015 v.52 no.2 pp. 226-235
ISSN:
0145-305X
Subject:
Danio rerio; Epinephelus coioides; Singapore grouper iridovirus; Takifugu rubripes; aquaculture; grouper; high-throughput nucleotide sequencing; immune response; microRNA; microarray technology; non-coding RNA; prediction; screening; sequence homology; spleen
Abstract:
... microRNAs (miRNAs) are an evolutionarily conserved class of non-coding RNA molecules that participate in various biological processes. Employment of high-throughput screening strategies greatly prompts the investigation and profiling of miRNAs in diverse species. In recent years, grouper (Epinephelus spp.) aquaculture was severely affected by iridoviral diseases. However, knowledge regarding the h ...
DOI:
10.1016/j.dci.2015.05.014

32. CpA/CpG methylation of CiMDA5 possesses tight association with the resistance against GCRV and negatively regulates mRNA expression in grass carp, Ctenopharyngodon idella

Author:
Xueying Shang; Jianguo Su; Quanyuan Wan; Juanjuan Su
Source:
Developmental and comparative immunology 2015 v.48 no.1 pp. 86-94
ISSN:
0145-305X
Subject:
quantitative polymerase chain reaction; sequence analysis; epigenetics; Ctenopharyngodon idella; messenger RNA; DNA methylation; genomic islands; Reoviridae; interferon regulatory factors; loci; gene expression regulation; reverse transcriptase polymerase chain reaction; transcription (genetics); gene expression; spleen; disease resistance; chi-square distribution; exons
Abstract:
... Melanoma differentiation-associated gene 5 (MDA5) plays a crucial role in recognizing intracellular viral infection, activating the interferon regulatory factor pathways as well as inducing antiviral response. While the antiviral regulatory mechanism of MDA5 remains unclear. In the present study, CiMDA5 (Ctenopharyngodon idella MDA5) against grass carp reovirus (GCRV) would be initially revealed f ...
DOI:
10.1016/j.dci.2014.09.007

33. CpG ODNs induced autophagy via reactive oxygen species (ROS) in Chinese mitten crab, Eriocheir sinensis

Author:
Mingzhe Sun; Lingling Wang; Shuai Jiang; Rui Liu; Depeng Zhao; Hao Chen; Xiaorui Song; Linsheng Song
Source:
Developmental and comparative immunology 2015 v.52 no.1 pp. 1-9
ISSN:
0145-305X
Subject:
Eriocheir sinensis; acetylcysteine; autophagy; crabs; fluorescent antibody technique; gene expression; genes; hemocytes; messenger RNA; oligodeoxyribonucleotides; reactive oxygen species
Abstract:
... Autophagy is a highly conserved intracellular homeostatic process involved in numerous responses in both vertebrate and invertebrate. In the present study, autophagy in hemocytes of Chinese mitten crab Eriocheir sinensis was observed by Western-blot and immunofluorescence assay, and its induction by CpG oligodeoxynucleotides (ODNs) was investigated. The increase of LC3-conversion (LC3-II/LC3-I) an ...
DOI:
10.1016/j.dci.2015.04.008

34. CsCTL1, a teleost C-type lectin that promotes antibacterial and antiviral immune defense in a manner that depends on the conserved EPN motif

Author:
Ze-jun Zhou; Li Sun
Source:
Developmental and comparative immunology 2015 v.50 no.2 pp. 69-77
ISSN:
0145-305X
Subject:
Cynoglossus semilaevis; antibacterial properties; bacteria; calcium; fish; immune response; kidneys; lectins; mammals; mannose; monocytes; mutants; phagocytosis
Abstract:
... Many C-type lectins (CTLs) have been identified in teleost, however, the in vivo function of fish CTLs is essentially unknown. In this study, we examined the function of a CTL (CsCTL1) from tongue sole. CsCTL1 possesses the conserved EPN motif required for mannose binding in mammals but unknown in function in fish. Recombinant CsCTL1 (rCsCTL1), but not the mutant rCsCTL1M bearing substitutions at ...
DOI:
10.1016/j.dci.2015.01.007

35. Ctenopharyngodon idella IRF2 plays an antagonistic role to IRF1 in transcriptional regulation of IFN and ISG genes

Author:
Meihui Gu; Gang Lin; Qinan Lai; Bin Zhong; Yong Liu; Yichuan Mi; Huarong Chen; Binhua Wang; Lihua Fan; Chengyu Hu
Source:
Developmental and comparative immunology 2015 v.49 no.1 pp. 103-112
ISSN:
0145-305X
Subject:
Ctenopharyngodon idella; DNA-binding domains; Danio rerio; Escherichia coli; affinity chromatography; amino acids; brain; complementary DNA; fish; gels; gene expression regulation; genes; interferon regulatory factors; kidneys; open reading frames; phylogeny; plasmids; promoter regions; sequence analysis; transcription (genetics); viruses
Abstract:
... Interferon Regulatory Factors (IRFs) make up a family of transcription factors involved in transcriptional regulation of type I IFN and IFN-stimulated genes (ISG) in cells. In the present study, an IRF2 gene (termed CiIRF2, JX628585) was cloned and characterized from grass carp (Ctenopharyngodon idella). The full-length cDNA of CiIRF2 is 1809 bp in length, with the largest open reading frame (ORF) ...
DOI:
10.1016/j.dci.2014.11.014

36. Cxcl8-l1 and Cxcl8-l2 are required in the zebrafish defense against Salmonella Typhimurium

Author:
Sofia de Oliveira; Azucena Lopez-Muñoz; Francisco J. Martínez-Navarro; Jorge Galindo-Villegas; Victoriano Mulero; Ângelo Calado
Source:
Developmental and comparative immunology 2015 v.49 no.1 pp. 44-48
ISSN:
0145-305X
Subject:
Danio rerio; Salmonella Typhimurium; gene expression; humans; inflammation; interleukin-8; larvae; models; neutrophils; signal transduction
Abstract:
... In recent years zebrafish has emerged as an excellent model for studying the Cxcl8 signaling pathway in inflammation elicited upon tissue damage or infection. Zebrafish has two true homologs of mammalian CXCL8, named Cxcl8-l1 and Cxcl8-l2. Previously, we have shown that in wound-associated inflammation, these chemokines are up-regulated and are relevant for neutrophil recruitment. In infections, n ...
DOI:
10.1016/j.dci.2014.11.004

37. A DN-mda5 transgenic zebrafish model demonstrates that Mda5 plays an important role in snakehead rhabdovirus resistance

Author:
K.A. Gabor; J.R. Charette; M.J. Pietraszewski; D.J. Wingfield; J.S. Shim; P.J. Millard; C.H. Kim
Source:
Developmental and comparative immunology 2015 v.51 no.2 pp. 298-304
ISSN:
0145-305X
Subject:
Danio rerio; Rhabdoviridae; disease resistance; genes; immune response; melanoma; models; nucleic acids; transgenic animals
Abstract:
... Melanoma Differentiation-Associated protein 5 (MDA5) is a member of the retinoic acid-inducible gene I (RIG-I)-like receptor (RLR) family, which is a cytosolic pattern recognition receptor that detects viral nucleic acids. Here we show an Mda5-dependent response to rhabdovirus infection in vivo using a dominant-negative mda5 transgenic zebrafish. Dominant-negative mda5 zebrafish embryos displayed ...
DOI:
10.1016/j.dci.2015.01.006
PubMed:
25634485
PubMed Central:
PMC4442029

38. The DNA fibers of shrimp hemocyte extracellular traps are essential for the clearance of Escherichia coli

Author:
Tze Hann Ng; Miao-Hsien Wu; Sheng-Hsiung Chang; Takashi Aoki; Han-Ching Wang
Source:
Developmental and comparative immunology 2015 v.48 no.1 pp. 229-233
ISSN:
0145-305X
Subject:
DNA; Escherichia coli; antibacterial properties; deoxyribonuclease I; hemocytes; histones; immune response; phagocytosis; shrimp; vertebrates
Abstract:
... Extracellular traps (ETs) are a part of the vertebrate immune response that was only recently discovered. These structures are formed in response to pathogenic invasion and they act to kill the invader. Vertebrate ETs are composed of chromosomal DNA, histone proteins and other antimicrobial cytoplasmic proteins. Pathogenic stimulation was also recently shown to trigger a similar ET response in shr ...
DOI:
10.1016/j.dci.2014.10.011

39. Development of an in vitro model system to study the interactions between Mycobacterium marinum and teleost neutrophils

Author:
Jordan W. Hodgkinson; Jun-Qing Ge; Barbara A. Katzenback; Jeffrey J. Havixbeck; Daniel R. Barreda; James L. Stafford; Miodrag Belosevic
Source:
Developmental and comparative immunology 2015 v.53 no.2 pp. 349-357
ISSN:
0145-305X
Subject:
Bacilli; Mycobacterium marinum; chemotaxis; cytokine receptors; defense mechanisms; goldfish; in vitro culture; interleukin-1beta; mammals; messenger RNA; mycobacterial diseases; neutrophils; pathogens; reactive oxygen species; viability
Abstract:
... The lack of a reliable mammalian neutrophil in vitro culture system has restricted our ability to examine their precise roles in mycobacterial infections. Previously, we developed the procedures for the isolation and culture of primary kidney-derived neutrophil-like cells from goldfish that are functionally and morphologically similar to mammalian neutrophils. The cultured primary goldfish neutrop ...
DOI:
10.1016/j.dci.2015.07.016

40. Development of antimicrobial peptide defenses of southern leopard frogs, Rana sphenocephala, against the pathogenic chytrid fungus, Batrachochytrium dendrobatidis

Author:
Whitney M. Holden; Laura K. Reinert; Shane M. Hanlon; Matthew J. Parris; Louise A. Rollins-Smith
Source:
Developmental and comparative immunology 2015 v.48 no.1 pp. 65-75
ISSN:
0145-305X
Subject:
Lithobates; Rana; adenosine monophosphate; antimicrobial peptides; bacteria; extinction; frogs; fungi; mass spectrometry; minimum inhibitory concentration; norepinephrine; ontogeny; pathogens; secretion; skin glands
Abstract:
... Amphibian species face the growing threat of extinction due to the emerging fungal pathogen Batrachochytrium dendrobatidis, which causes the disease chytridiomycosis. Antimicrobial peptides (AMPs) produced in granular glands of the skin are an important defense against this pathogen. Little is known about the ontogeny of AMP production or the impact of AMPs on potentially beneficial symbiotic skin ...
DOI:
10.1016/j.dci.2014.09.003

41. Different strategies for producing naturally soluble form of common cytokine receptor γ chain

Author:
Jipseol Jeong; Woo H. Kim; Cherry P. Fernandez; Suk Kim; Yong-Hwan Kim; Hyung-Kwan Jang; Hyun S. Lillehoj; Hee-Jong Woo; Wongi Min
Source:
Developmental and comparative immunology 2015 v.48 no.1 pp. 13-21
ISSN:
0145-305X
Subject:
chickens; lymph; alternative splicing; messenger RNA; probability; antigens; cysteine proteinase inhibitors; cytokine receptors; ducks; developmental stages; humans; immunosuppression; proteolysis; serine; gene expression; mice; homeostasis; introns
Abstract:
... The common cytokine receptor γ chain (γc) plays an essential role in regulating lymphoid homeostasis. In fact, alteration of this gene causes severe immunodeficiency in humans and animals. Although soluble γc (sγc) was identified in the late 1990s, much remains unknown about its production. This study describes various mechanisms underlying the generation of sγc isoforms in different species. Our ...
Handle:
10113/61087
DOI:
10.1016/j.dci.2014.08.008

42. Differential immune gene expression profiles in susceptible and resistant full-sibling families of Atlantic salmon (Salmo salar) challenged with infectious pancreatic necrosis virus (IPNV)

Author:
Felipe E. Reyes-López; Jose S. Romeo; Eva Vallejos-Vidal; Sebastián Reyes-Cerpa; Ana M. Sandino; Lluis Tort; Simon Mackenzie; Mónica Imarai
Source:
Developmental and comparative immunology 2015 v.53 no.1 pp. 210-221
ISSN:
0145-305X
Subject:
Infectious pancreatic necrosis virus; Salmo salar; antigen presentation; antigens; complement; fish; gene expression; gene expression regulation; genes; immune response; immunosuppression; interferon-alpha; interferon-gamma; interleukin-10; interleukin-12; interleukin-6; kidneys; leukocytes; metabolism; microarray technology; models; mortality; oligonucleotides; phenotype; protein degradation; quantitative polymerase chain reaction; transcriptomics; transforming growth factor beta 1
Abstract:
... This study aims to identify at the expression level the immune-related genes associated with IPN-susceptible and resistant phenotypes in Atlantic salmon full-sibling families. We have analyzed thirty full-sibling families infected by immersion with IPNV and then classified as resistant or susceptible using a multivariate survival analysis based on a gamma-Cox frailty model and the Kaplan–Meier mor ...
DOI:
10.1016/j.dci.2015.06.017

43. Digenean-gastropod host associations inform on aspects of specific immunity in snails

Author:
C.M. Adema; E.S. Loker
Source:
Developmental and comparative immunology 2015 v.48 no.2 pp. 275-283
ISSN:
0145-305X
Subject:
Biomphalaria glabrata; Trematoda; antigens; host specificity; immune response; parasites; proteins; snails
Abstract:
... Gastropod immunology is informed importantly by the study of the frequent encounters snails endure with digeneans (digenetic trematodes). One of the hallmarks of gastropod-digenean associations is their specificity: any particular digenean parasite species is transmitted by a limited subset of snail taxa. We discuss the nature of this specificity, including its immunological basis. We then review ...
DOI:
10.1016/j.dci.2014.06.014
PubMed:
25034871
PubMed Central:
PMC4258543

44. Distribution of EP4 receptor in different Atlantic salmon (Salmo salar L.) tissues

Author:
A.A.A. Gamil; T.-C. Guo; M. König; Ø. Evensen
Source:
Developmental and comparative immunology 2015 v.48 no.1 pp. 143-150
ISSN:
0145-305X
Subject:
Salmo salar; antibodies; brain; fish; heart; immune response; immunohistochemistry; kidneys; mammals; muscles; prostaglandins; quantitative analysis; quantitative polymerase chain reaction; receptors; reverse transcriptase polymerase chain reaction; signal transduction; spleen; staining
Abstract:
... Prostaglandin E2 (PGE2) is an important lipid mediator that plays diverse functions in mammals. Four receptor subtypes of PGE2, designated EP1-4, have been identified to mediate its signaling pathways. Extensive studies of PGE2 and its receptors have been carried out in mammals, but little is known in fish, including Atlantic salmon. In the current study, the distribution of Atlantic salmon EP4 re ...
DOI:
10.1016/j.dci.2014.09.013

45. Diversity of animal immune receptors and the origins of recognition complexity in the deuterostomes

Author:
Katherine M. Buckley; Jonathan P. Rast
Source:
Developmental and comparative immunology 2015 v.49 no.1 pp. 179-189
ISSN:
0145-305X
Subject:
Echinoidea; Toll-like receptors; binding proteins; genomics; immune response; invertebrates; life history; longevity; multigene family; nucleotide sequences; peptidoglycans
Abstract:
... Invertebrate animals are characterized by extraordinary diversity in terms of body plan, life history and life span. The past impression that invertebrate immune responses are controlled by relatively simple innate systems is increasingly contradicted by genomic analyses that reveal significant evolutionary novelty and complexity. One accessible measure of this complexity is the multiplicity of ge ...
DOI:
10.1016/j.dci.2014.10.013

46. Dscam and pancrustacean immune memory – A review of the evidence

Author:
Sophie A.O. Armitage; Robert Peuß; Joachim Kurtz
Source:
Developmental and comparative immunology 2015 v.48 no.2 pp. 315-323
ISSN:
0145-305X
Subject:
Crustacea; Down syndrome; cell adhesion; immunologic memory; insects; invertebrates; pathogens
Abstract:
... Evidence is accumulating for a memory-like phenomenon in the immune defence of invertebrates. Down syndrome cell adhesion molecule (Dscam) has been proposed as a key candidate for a somatically diversified receptor system in the crustaceans and insects (Pancrustacea) that could enable challenge-specific protection. However, what is the evidence for an involvement of Dscam in pancrustacean immune m ...
DOI:
10.1016/j.dci.2014.03.004

47. Effect of the synthetic Toll-like receptor ligands LPS, Pam3CSK4, HKLM and FSL-1 in the function of bovine polymorphonuclear neutrophils

Author:
Iván Conejeros; Amanda J. Gibson; Dirk Werling; Tamara Muñoz-Caro; Carlos Hermosilla; Anja Taubert; Rafael A. Burgos
Source:
Developmental and comparative immunology 2015 v.52 no.2 pp. 215-225
ISSN:
0145-305X
Subject:
Toll-like receptor 2; Toll-like receptor 4; apoptosis; calcium; cattle; flow cytometry; granules; humans; innate immunity; ligands; mice; neutrophils; nucleic acids; secretion
Abstract:
... Toll-like receptors (TLR) are a family of pattern recognition receptors that sense microbial associated molecular patterns (MAMP) such as microbial membrane components and nucleic acids of bacterial origin. Polymorphonuclear neutrophils (PMN) are the first cell of the innate immune system to arrive at the site of infection or injury and elicit oxidative and non-oxidative microbicidal mechanisms. O ...
DOI:
10.1016/j.dci.2015.05.012

48. Equine immunoglobulins and organization of immunoglobulin genes

Author:
Stefanie Walther; Tamara V. Rusitzka; Ulrike S. Diesterbeck; Claus-Peter Czerny
Source:
Developmental and comparative immunology 2015 v.53 no.2 pp. 303-319
ISSN:
0145-305X
Subject:
adults; breeds; foals; genetic variation; immunoglobulin genes; immunoglobulins; pseudogenes; sequence diversity; transcription (genetics)
Abstract:
... Our understanding of how equine immunoglobulin genes are organized has increased significantly in recent years. For equine heavy chains, 52 IGHV, 40 IGHD, 8 IGHJ and 11 IGHC are present. Seven of these IGHCs are gamma chain genes. Sequence diversity is increasing between fetal, neonatal, foal and adult age. The kappa light chain contains 60 IGKV, 5 IGKJ and 1 IGKC, whereas there are 144 IGLV, 7 IG ...
DOI:
10.1016/j.dci.2015.07.017

49. Estrogen receptor 2b deficiency impairs the antiviral response of zebrafish

Author:
Azucena López-Muñoz; Sergio Liarte; Nuria E. Gómez-González; Isabel Cabas; José Meseguer; Alfonsa García-Ayala; Victoriano Mulero
Source:
Developmental and comparative immunology 2015 v.53 no.1 pp. 55-62
ISSN:
0145-305X
Subject:
Danio rerio; adults; amino acids; cytokines; endocrine-disrupting chemicals; estradiol; estrogen receptors; fish; genes; homozygosity; innate immunity; larvae; mutants; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; siblings; testes; testosterone
Abstract:
... Although several studies have demonstrated the ability of some endocrine disruptive chemicals (EDCs) to alter the physiology of zebrafish, the immune–reproductive interaction has received little attention in this species. In this study, we used a homozygous line carrying an insertion of 8 amino acids in the ligand-binding domain of the estrogen receptor 2b gene (esr2b) to further understand the ro ...
DOI:
10.1016/j.dci.2015.06.008

50. Evolution of akirin family in gene and genome levels and coexpressed patterns among family members and rel gene in croaker

Author:
Tianxing Liu; Yunhang Gao; Tianjun Xu
Source:
Developmental and comparative immunology 2015 v.52 no.1 pp. 17-25
ISSN:
0145-305X
Subject:
carcinogenesis; Miichthys miiuy; muscle development; innate immunity; evolution; nuclear proteins; vertebrates; signal transduction; Vibrio anguillarum; nuclear localization signals; embryogenesis; exons; introns; Chondrichthyes
Abstract:
... Akirins, which are highly conserved nuclear proteins, are present throughout the metazoan and regulate innate immunity, embryogenesis, myogenesis, and carcinogenesis. This study reports all akirin genes from miiuy croaker and analyzes comprehensively the akirin gene family combined with akirin genes from other species. A second nuclear localization signal (NLS) is observed in akirin2 homologues, w ...
DOI:
10.1016/j.dci.2015.04.010