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Developmental biology
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2019
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2019 v.445 no.2
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- Author:
- Dolan, Connor P.; Yan, Mingquan; Zimmel, Katherine; Yang, Tae-Jung; Leininger, Eric; Dawson, Lindsay A.; Muneoka, Ken
- Source:
- Developmental biology 2019 v.445 no.2 pp. 237-244
- ISSN:
- 0012-1606
- Subject:
- Schwann cells; amputation; axons; bone marrow; immunohistochemistry; innervation; mice; nerve regeneration; nerve tissue; peripheral nerves; regrowth; substance P; tyrosine 3-monooxygenase
- Abstract:
- ... Mice are intrinsically capable of regenerating the tips of their digits after amputation. Mouse digit tip regeneration is reported to be a peripheral nerve-dependent event. However, it is presently unknown what types of nerves and Schwann cells innervate the digit tip, and to what extent these cells regenerate in association with the regenerative response. Given the necessity of peripheral nerves ...
- DOI:
- 10.1016/j.ydbio.2018.11.010
- https://dx.doi.org/10.1016/j.ydbio.2018.11.010
2. Cardiac injections of AntagomiRs as a novel tool for knockdown of miRNAs during heart development
- Author:
- Wittig, Johannes G.; Billmeier, Martina; Lozano-Velasco, Estefanía; García, Miguel Robles-; Münsterberg, Andrea E.
- Source:
- Developmental biology 2019 v.445 no.2 pp. 163-169
- ISSN:
- 0012-1606
- Subject:
- chick embryos; chickens; embryogenesis; gene expression; genes; heart; microRNA; models; phenotype; therapeutics
- Abstract:
- ... Studying microRNA networks during heart development is essential to obtain a better understanding of developmental defects and diseases associated with the heart and to identify novel opportunities for therapeutics. Here we highlight the advantages of chicken embryos as a vertebrate model for studying intermediate processes of heart development. Avians develop a four-chambered heart closely resemb ...
- DOI:
- 10.1016/j.ydbio.2018.11.008
- https://dx.doi.org/10.1016/j.ydbio.2018.11.008
- Author:
- Materna, Stefan C.; Sinha, Tanvi; Barnes, Ralston M.; Lammerts van Bueren, Kelly; Black, Brian L.
- Source:
- Developmental biology 2019 v.445 no.2 pp. 170-177
- ISSN:
- 0012-1606
- Subject:
- abnormal development; death; embryogenesis; endothelium; germ cells; heart; knockout mutants; mice; phenotype; progeny; transcription factors; viability
- Abstract:
- ... MEF2C is a member of the highly conserved MEF2 family of transcription factors and is a key regulator of cardiovascular development. In mice, Mef2c is expressed in the developing heart and vasculature, including the endothelium. Loss of Mef2c function in germline knockout mice leads to early embryonic demise and profound developmental abnormalities in the cardiovascular system. Previous attempts t ...
- DOI:
- 10.1016/j.ydbio.2018.12.002
- PubMed:
- 30521808
- PubMed Central:
- PMC6370303
- https://dx.doi.org/10.1016/j.ydbio.2018.12.002
- Author:
- Kelu, Jeffrey J.; Webb, Sarah E.; Galione, Antony; Miller, Andrew L.
- Source:
- Developmental biology 2019 v.445 no.2 pp. 211-225
- ISSN:
- 0012-1606
- Subject:
- Danio rerio; Golgi apparatus; N-glycoside hydrolases; adenine; calcium; calcium signaling; cell culture; cell differentiation; embryo (animal); messenger RNA; molecular cloning; muscle development; niacin; nicotinamide; phosphates; plasma membrane; sarcoplasmic reticulum
- Abstract:
- ... We recently demonstrated the requirement of two-pore channel type 2 (TPC2)-mediated Ca2+ release during slow muscle cell differentiation and motor circuit maturation in intact zebrafish embryos. However, the upstream trigger(s) of TPC2/Ca2+ signaling during these developmental processes remains unclear. Nicotinic acid adenine dinucleotide phosphate (NAADP) is a potent Ca2+ mobilizing messenger, wh ...
- DOI:
- 10.1016/j.ydbio.2018.11.005
- PubMed:
- 30447180
- PubMed Central:
- PMC6675606
- https://dx.doi.org/10.1016/j.ydbio.2018.11.005
- Author:
- Ben Maamar, Millissia; Nilsson, Eric; Sadler-Riggleman, Ingrid; Beck, Daniel; McCarrey, John R.; Skinner, Michael K.
- Source:
- Developmental biology 2019 v.445 no.2 pp. 280-293
- ISSN:
- 0012-1606
- Subject:
- DDT (pesticide); DNA methylation; adults; diet; environmental factors; epididymis; epigenetics; genomics; inheritance (genetics); males; pachytene stage; phenotypic variation; rats; spermatids; spermatocytes; spermatogenesis; spermatogonia; spermatozoa; testes; toxic substances
- Abstract:
- ... Epigenetic alterations in the germline can be triggered by a number of different environmental factors from diet to toxicants. These environmentally induced germline changes can promote the epigenetic transgenerational inheritance of disease and phenotypic variation. In previous studies, the pesticide DDT was shown to promote the transgenerational inheritance of sperm differential DNA methylation ...
- DOI:
- 10.1016/j.ydbio.2018.11.016
- PubMed:
- 30500333
- PubMed Central:
- PMC6338333
- https://dx.doi.org/10.1016/j.ydbio.2018.11.016
- Author:
- Brokhman, Irina; Xu, Jie; Coles, Brenda L.K.; Razavi, Rozita; Engert, Silvia; Lickert, Heiko; Babona-Pilipos, Robert; Morshead, Cindi M.; Sibley, Eric; Chen, Chin; van der Kooy, Derek
- Source:
- Developmental biology 2019 v.445 no.2 pp. 256-270
- ISSN:
- 0012-1606
- Subject:
- Petrorhagia; adults; duodenum; endoderm; genetically modified organisms; mice; muscles; neural crest; neuroglia; neurons; pancreas; progeny; stem cells
- Abstract:
- ... The enteric nervous system is thought to originate solely from the neural crest. Transgenic lineage tracing revealed a novel population of clonal pancreatic duodenal homeobox-1 (Pdx1)-Cre lineage progenitor cells in the tunica muscularis of the gut that produced pancreatic descendants as well as neurons upon differentiation in vitro. Additionally, an in vivo subpopulation of endoderm lineage enter ...
- DOI:
- 10.1016/j.ydbio.2018.11.014
- https://dx.doi.org/10.1016/j.ydbio.2018.11.014
- Author:
- Jena, Manoj Kumar; Jaswal, Shalini; Kumar, Sudarshan; Mohanty, Ashok Kumar
- Source:
- Developmental biology 2019 v.445 no.2 pp. 145-155
- ISSN:
- 0012-1606
- Subject:
- apoptosis; carcinogenesis; epithelial cells; growth factors; hormones; lactation; mammary glands; milk; milk synthesis; neoplasms; pregnancy; puberty; secretion; signal transduction; transactivators
- Abstract:
- ... The mammary gland (MG) is a unique organ responsible for milk synthesis, secretion, and involution to prepare the gland for subsequent lactation. The mammary epithelial cells (MECs), which are the milk synthesizing units of the MG, proliferate, differentiate, undergo apoptosis and regenerate following a cyclic pathway of lactation – involution – lactation, fine-tuning these molecular events throug ...
- DOI:
- 10.1016/j.ydbio.2018.11.002
- https://dx.doi.org/10.1016/j.ydbio.2018.11.002
- Author:
- Planques, Anabelle; Malem, Julien; Parapar, Julio; Vervoort, Michel; Gazave, Eve
- Source:
- Developmental biology 2019 v.445 no.2 pp. 189-210
- ISSN:
- 0012-1606
- Subject:
- Annelida; amputation; animals; cell proliferation; models; pharynx; tissue repair
- Abstract:
- ... Regeneration, the ability to restore body parts after an injury or an amputation, is a widespread but highly variable and complex phenomenon in animals. While having fascinated scientists for centuries, fundamental questions about the cellular basis of animal regeneration as well as its evolutionary history remain largely unanswered. Here, we present a study of regeneration of the marine annelid P ...
- DOI:
- 10.1016/j.ydbio.2018.11.004
- https://dx.doi.org/10.1016/j.ydbio.2018.11.004
- Author:
- Mehravar, Maryam; Shirazi, Abolfazl; Nazari, Mahboobeh; Banan, Mehdi
- Source:
- Developmental biology 2019 v.445 no.2 pp. 156-162
- ISSN:
- 0012-1606
- Subject:
- animals; gene editing; genotyping; germ cells; mutation
- Abstract:
- ... The CRISPR/Cas9 system is a rapid, simple, and often extremely efficient gene editing method. This method has been used in a variety of organisms and cell types over the past several years. However, using this technology for generating gene-edited animals involves a number of obstacles. One such obstacle is mosaicism, which is common in founder animals. This is especially the case when the CRISPR/ ...
- DOI:
- 10.1016/j.ydbio.2018.10.008
- https://dx.doi.org/10.1016/j.ydbio.2018.10.008
- Author:
- Yang, Ronghua; Wang, Jingru; Zhou, Ziheng; Qi, Shaohai; Ruan, Shubin; Lin, Zepeng; Xin, Qi; Lin, Yan; Chen, Xiaodong; Xie, Julin
- Source:
- Developmental biology 2019 v.445 no.2 pp. 271-279
- ISSN:
- 0012-1606
- Subject:
- animal models; burns (injuries); cell proliferation; epidermal growth factor; epidermis (animal); histology; messenger RNA; mice; rats; stem cells; therapeutics; tissue repair
- Abstract:
- ... Local transplantation of stem cells has therapeutic effects on skin damage but cannot provide satisfactory wound healing. Studies on the mechanisms underlying the therapeutic effects of stem cells on skin wound healing will be needed. Hence, in the present study, we explored the role of Caveolin-1 in epidermal stem cells (EpiSCs) in the modulation of wound healing. We first isolated EpiSCs from mo ...
- DOI:
- 10.1016/j.ydbio.2018.11.015
- https://dx.doi.org/10.1016/j.ydbio.2018.11.015
- Author:
- Oonuma, Kouhei; Kusakabe, Takehiro G.
- Source:
- Developmental biology 2019 v.445 no.2 pp. 245-255
- ISSN:
- 0012-1606
- Subject:
- Ciona; kinship; larvae; mitosis; ocelli; photoreceptors; vertebrates
- Abstract:
- ... The ascidian larva has a pigmented ocellus comprised of a cup-shaped array of approximately 30 photoreceptor cells, a pigment cell, and three lens cells. Morphological, physiological and molecular evidence has suggested evolutionary kinship between the ascidian larval photoreceptors and vertebrate retinal and/or pineal photoreceptors. Rx, an essential factor for vertebrate photoreceptor developmen ...
- DOI:
- 10.1016/j.ydbio.2018.11.011
- https://dx.doi.org/10.1016/j.ydbio.2018.11.011
- Author:
- Zandvakili, Arya; Uhl, Juli D.; Campbell, Ian; Salomone, Joseph; Song, Yuntao Charlie; Gebelein, Brian
- Source:
- Developmental biology 2019 v.445 no.2 pp. 226-236
- ISSN:
- 0012-1606
- Subject:
- Drosophila; binding sites; epidermal growth factor; gene expression; genes; regulatory sequences; secretion; transcription (genetics); transcription factors
- Abstract:
- ... During development diverse transcription factor inputs are integrated by cis-regulatory modules (CRMs) to yield cell-specific gene expression. Defining how CRMs recruit the appropriate combinations of factors to either activate or repress gene expression remains a challenge. In this study, we compare and contrast the ability of two CRMs within the Drosophila embryo to recruit functional Hox transc ...
- DOI:
- 10.1016/j.ydbio.2018.11.006
- PubMed:
- 30468713
- PubMed Central:
- PMC6333500
- https://dx.doi.org/10.1016/j.ydbio.2018.11.006
- Author:
- Morohoshi, Akane; Nakagawa, Tadashi; Nakano, Seiji; Nagasawa, Yuko; Nakayama, Keiko
- Source:
- Developmental biology 2019 v.445 no.2 pp. 178-188
- ISSN:
- 0012-1606
- Subject:
- Sertoli cells; cadherins; gene expression regulation; genes; males; meiosis; mice; mutants; spermatids; spermatogenesis; spermatogonia; spermatozoa; transcription factors; ubiquitin-protein ligase
- Abstract:
- ... β-TrCP is the substrate recognition subunit of an SCF-type ubiquitin ligase. We recently showed that deletion of the genes for both β-TrCP1 and β-TrCP2 paralogs in germ cells of male mice resulted in accumulation of the transcription factor DMRT1 and spermatogenic failure, whereas systemic β-TrCP1 knockout combined with β-TrCP2 knockdown had previously been shown to lead to disruption of testicula ...
- DOI:
- 10.1016/j.ydbio.2018.10.023
- https://dx.doi.org/10.1016/j.ydbio.2018.10.023