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You searched for: Journal Developmental biology Remove constraint Journal: Developmental biology Publication Year 2019 Remove constraint Publication Year: 2019 Source 2019 v.445 no.2 Remove constraint Source: 2019 v.445 no.2
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1. Axonal regrowth is impaired during digit tip regeneration in mice

Author:
Dolan, Connor P.; Yan, Mingquan; Zimmel, Katherine; Yang, Tae-Jung; Leininger, Eric; Dawson, Lindsay A.; Muneoka, Ken
Source:
Developmental biology 2019 v.445 no.2 pp. 237-244
ISSN:
0012-1606
Subject:
Schwann cells; amputation; axons; bone marrow; immunohistochemistry; innervation; mice; nerve regeneration; nerve tissue; peripheral nerves; regrowth; substance P; tyrosine 3-monooxygenase
Abstract:
... Mice are intrinsically capable of regenerating the tips of their digits after amputation. Mouse digit tip regeneration is reported to be a peripheral nerve-dependent event. However, it is presently unknown what types of nerves and Schwann cells innervate the digit tip, and to what extent these cells regenerate in association with the regenerative response. Given the necessity of peripheral nerves ...
DOI:
10.1016/j.ydbio.2018.11.010

2. Cardiac injections of AntagomiRs as a novel tool for knockdown of miRNAs during heart development

Author:
Wittig, Johannes G.; Billmeier, Martina; Lozano-Velasco, Estefanía; García, Miguel Robles-; Münsterberg, Andrea E.
Source:
Developmental biology 2019 v.445 no.2 pp. 163-169
ISSN:
0012-1606
Subject:
chick embryos; chickens; embryogenesis; gene expression; genes; heart; microRNA; models; phenotype; therapeutics
Abstract:
... Studying microRNA networks during heart development is essential to obtain a better understanding of developmental defects and diseases associated with the heart and to identify novel opportunities for therapeutics. Here we highlight the advantages of chicken embryos as a vertebrate model for studying intermediate processes of heart development. Avians develop a four-chambered heart closely resemb ...
DOI:
10.1016/j.ydbio.2018.11.008

3. Cardiovascular development and survival require Mef2c function in the myocardial but not the endothelial lineage

Author:
Materna, Stefan C.; Sinha, Tanvi; Barnes, Ralston M.; Lammerts van Bueren, Kelly; Black, Brian L.
Source:
Developmental biology 2019 v.445 no.2 pp. 170-177
ISSN:
0012-1606
Subject:
abnormal development; death; embryogenesis; endothelium; germ cells; heart; knockout mutants; mice; phenotype; progeny; transcription factors; viability
Abstract:
... MEF2C is a member of the highly conserved MEF2 family of transcription factors and is a key regulator of cardiovascular development. In mice, Mef2c is expressed in the developing heart and vasculature, including the endothelium. Loss of Mef2c function in germline knockout mice leads to early embryonic demise and profound developmental abnormalities in the cardiovascular system. Previous attempts t ...
DOI:
10.1016/j.ydbio.2018.12.002

4. Characterization of ADP-ribosyl cyclase 1-like (ARC1-like) activity and NAADP signaling during slow muscle cell development in zebrafish embryos

Author:
Kelu, Jeffrey J.; Webb, Sarah E.; Galione, Antony; Miller, Andrew L.
Source:
Developmental biology 2019 v.445 no.2 pp. 211-225
ISSN:
0012-1606
Subject:
Danio rerio; Golgi apparatus; N-glycoside hydrolases; adenine; calcium; calcium signaling; cell culture; cell differentiation; embryo (animal); messenger RNA; molecular cloning; muscle development; niacin; nicotinamide; phosphates; plasma membrane; sarcoplasmic reticulum
Abstract:
... We recently demonstrated the requirement of two-pore channel type 2 (TPC2)-mediated Ca2+ release during slow muscle cell differentiation and motor circuit maturation in intact zebrafish embryos. However, the upstream trigger(s) of TPC2/Ca2+ signaling during these developmental processes remains unclear. Nicotinic acid adenine dinucleotide phosphate (NAADP) is a potent Ca2+ mobilizing messenger, wh ...
DOI:
10.1016/j.ydbio.2018.11.005

5. Developmental origins of transgenerational sperm DNA methylation epimutations following ancestral DDT exposure

Author:
Ben Maamar, Millissia; Nilsson, Eric; Sadler-Riggleman, Ingrid; Beck, Daniel; McCarrey, John R.; Skinner, Michael K.
Source:
Developmental biology 2019 v.445 no.2 pp. 280-293
ISSN:
0012-1606
Subject:
DDT (pesticide); DNA methylation; adults; diet; environmental factors; epididymis; epigenetics; genomics; inheritance (genetics); males; pachytene stage; phenotypic variation; rats; spermatids; spermatocytes; spermatogenesis; spermatogonia; spermatozoa; testes; toxic substances
Abstract:
... Epigenetic alterations in the germline can be triggered by a number of different environmental factors from diet to toxicants. These environmentally induced germline changes can promote the epigenetic transgenerational inheritance of disease and phenotypic variation. In previous studies, the pesticide DDT was shown to promote the transgenerational inheritance of sperm differential DNA methylation ...
DOI:
10.1016/j.ydbio.2018.11.016

6. Dual embryonic origin of the mammalian enteric nervous system

Author:
Brokhman, Irina; Xu, Jie; Coles, Brenda L.K.; Razavi, Rozita; Engert, Silvia; Lickert, Heiko; Babona-Pilipos, Robert; Morshead, Cindi M.; Sibley, Eric; Chen, Chin; van der Kooy, Derek
Source:
Developmental biology 2019 v.445 no.2 pp. 256-270
ISSN:
0012-1606
Subject:
Petrorhagia; adults; duodenum; endoderm; genetically modified organisms; mice; muscles; neural crest; neuroglia; neurons; pancreas; progeny; stem cells
Abstract:
... The enteric nervous system is thought to originate solely from the neural crest. Transgenic lineage tracing revealed a novel population of clonal pancreatic duodenal homeobox-1 (Pdx1)-Cre lineage progenitor cells in the tunica muscularis of the gut that produced pancreatic descendants as well as neurons upon differentiation in vitro. Additionally, an in vivo subpopulation of endoderm lineage enter ...
DOI:
10.1016/j.ydbio.2018.11.014

7. Molecular mechanism of mammary gland involution: An update

Author:
Jena, Manoj Kumar; Jaswal, Shalini; Kumar, Sudarshan; Mohanty, Ashok Kumar
Source:
Developmental biology 2019 v.445 no.2 pp. 145-155
ISSN:
0012-1606
Subject:
apoptosis; carcinogenesis; epithelial cells; growth factors; hormones; lactation; mammary glands; milk; milk synthesis; neoplasms; pregnancy; puberty; secretion; signal transduction; transactivators
Abstract:
... The mammary gland (MG) is a unique organ responsible for milk synthesis, secretion, and involution to prepare the gland for subsequent lactation. The mammary epithelial cells (MECs), which are the milk synthesizing units of the MG, proliferate, differentiate, undergo apoptosis and regenerate following a cyclic pathway of lactation – involution – lactation, fine-tuning these molecular events throug ...
DOI:
10.1016/j.ydbio.2018.11.002

8. Morphological, cellular and molecular characterization of posterior regeneration in the marine annelid Platynereis dumerilii

Author:
Planques, Anabelle; Malem, Julien; Parapar, Julio; Vervoort, Michel; Gazave, Eve
Source:
Developmental biology 2019 v.445 no.2 pp. 189-210
ISSN:
0012-1606
Subject:
Annelida; amputation; animals; cell proliferation; models; pharynx; tissue repair
Abstract:
... Regeneration, the ability to restore body parts after an injury or an amputation, is a widespread but highly variable and complex phenomenon in animals. While having fascinated scientists for centuries, fundamental questions about the cellular basis of animal regeneration as well as its evolutionary history remain largely unanswered. Here, we present a study of regeneration of the marine annelid P ...
DOI:
10.1016/j.ydbio.2018.11.004

9. Mosaicism in CRISPR/Cas9-mediated genome editing

Author:
Mehravar, Maryam; Shirazi, Abolfazl; Nazari, Mahboobeh; Banan, Mehdi
Source:
Developmental biology 2019 v.445 no.2 pp. 156-162
ISSN:
0012-1606
Subject:
animals; gene editing; genotyping; germ cells; mutation
Abstract:
... The CRISPR/Cas9 system is a rapid, simple, and often extremely efficient gene editing method. This method has been used in a variety of organisms and cell types over the past several years. However, using this technology for generating gene-edited animals involves a number of obstacles. One such obstacle is mosaicism, which is common in founder animals. This is especially the case when the CRISPR/ ...
DOI:
10.1016/j.ydbio.2018.10.008

10. Role of caveolin-1 in epidermal stem cells during burn wound healing in rats

Author:
Yang, Ronghua; Wang, Jingru; Zhou, Ziheng; Qi, Shaohai; Ruan, Shubin; Lin, Zepeng; Xin, Qi; Lin, Yan; Chen, Xiaodong; Xie, Julin
Source:
Developmental biology 2019 v.445 no.2 pp. 271-279
ISSN:
0012-1606
Subject:
animal models; burns (injuries); cell proliferation; epidermal growth factor; epidermis (animal); histology; messenger RNA; mice; rats; stem cells; therapeutics; tissue repair
Abstract:
... Local transplantation of stem cells has therapeutic effects on skin damage but cannot provide satisfactory wound healing. Studies on the mechanisms underlying the therapeutic effects of stem cells on skin wound healing will be needed. Hence, in the present study, we explored the role of Caveolin-1 in epidermal stem cells (EpiSCs) in the modulation of wound healing. We first isolated EpiSCs from mo ...
DOI:
10.1016/j.ydbio.2018.11.015

11. Spatio-temporal regulation of Rx and mitotic patterns shape the eye-cup of the photoreceptor cells in Ciona

Author:
Oonuma, Kouhei; Kusakabe, Takehiro G.
Source:
Developmental biology 2019 v.445 no.2 pp. 245-255
ISSN:
0012-1606
Subject:
Ciona; kinship; larvae; mitosis; ocelli; photoreceptors; vertebrates
Abstract:
... The ascidian larva has a pigmented ocellus comprised of a cup-shaped array of approximately 30 photoreceptor cells, a pigment cell, and three lens cells. Morphological, physiological and molecular evidence has suggested evolutionary kinship between the ascidian larval photoreceptors and vertebrate retinal and/or pineal photoreceptors. Rx, an essential factor for vertebrate photoreceptor developmen ...
DOI:
10.1016/j.ydbio.2018.11.011

12. The cis-regulatory logic underlying abdominal Hox-mediated repression versus activation of regulatory elements in Drosophila

Author:
Zandvakili, Arya; Uhl, Juli D.; Campbell, Ian; Salomone, Joseph; Song, Yuntao Charlie; Gebelein, Brian
Source:
Developmental biology 2019 v.445 no.2 pp. 226-236
ISSN:
0012-1606
Subject:
Drosophila; binding sites; epidermal growth factor; gene expression; genes; regulatory sequences; secretion; transcription (genetics); transcription factors
Abstract:
... During development diverse transcription factor inputs are integrated by cis-regulatory modules (CRMs) to yield cell-specific gene expression. Defining how CRMs recruit the appropriate combinations of factors to either activate or repress gene expression remains a challenge. In this study, we compare and contrast the ability of two CRMs within the Drosophila embryo to recruit functional Hox transc ...
DOI:
10.1016/j.ydbio.2018.11.006

13. The ubiquitin ligase subunit β-TrCP in Sertoli cells is essential for spermatogenesis in mice

Author:
Morohoshi, Akane; Nakagawa, Tadashi; Nakano, Seiji; Nagasawa, Yuko; Nakayama, Keiko
Source:
Developmental biology 2019 v.445 no.2 pp. 178-188
ISSN:
0012-1606
Subject:
Sertoli cells; cadherins; gene expression regulation; genes; males; meiosis; mice; mutants; spermatids; spermatogenesis; spermatogonia; spermatozoa; transcription factors; ubiquitin-protein ligase
Abstract:
... β-TrCP is the substrate recognition subunit of an SCF-type ubiquitin ligase. We recently showed that deletion of the genes for both β-TrCP1 and β-TrCP2 paralogs in germ cells of male mice resulted in accumulation of the transcription factor DMRT1 and spermatogenic failure, whereas systemic β-TrCP1 knockout combined with β-TrCP2 knockdown had previously been shown to lead to disruption of testicula ...
DOI:
10.1016/j.ydbio.2018.10.023