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- McConnell, Alicia M.; Mito, Jeffrey K.; Ablain, Julien; Dang, Michelle; Formichella, Luke; Fisher, David E.; Zon, Leonard I.
- Developmental biology 2019 v.449 no.2 pp. 107-114
- Danio rerio; fish; fluorescence; genetically modified organisms; histology; melanocytes; melanoma; models; mutation; neural crest; oncogenes; phenotype; transcription (genetics)
- ... NRAS mutations are frequently found in many deadly malignancies and are the second most common oncogene driving malignant melanoma. Here, we generate a rapid transient transgenic zebrafish model of NRASQ61R-mutant melanoma. These fish develop extensive melanocytic proliferation in approximately 4 weeks. The majority of these lesions do not engraft upon transplantation and lack overt histologic fea ...
- Tadokoro, Ryosuke; Shikaya, Yuuki; Takahashi, Yoshiko
- Developmental biology 2019 v.449 no.2 pp. 83-89
- chickens; humans; keratinocytes; melanin; melanocytes; mice; neural crest; pigmentation; quantitative analysis; surface area; ultraviolet radiation
- ... Skin pigmentation is a powerful defense against ultraviolet irradiation. Particularly in humans, the body surface needs to be widely covered by protective pigmentation, and melanocytes, a major lineage of neural crest derivatives, have evolved several maneuvers to transfer melanin pigment to the skin. Recent studies with embryonic melanocytes of chickens and mice have revealed sequential events me ...