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- Okano, Hideyuki, et al. Show all 10 Authors
- Developmental biology 2012 v.363 no.1 pp. 106-114
- angiogenesis; astrocytes; central nervous system; hypoxia; hypoxia-inducible factor 1; mice; oxygen; platelet-derived growth factor; pseudopodia; retina; stem cells; vascular endothelial growth factors
- ... The vascular and nervous systems display a high degree of cross-talk and depend on each other functionally. In the vascularization of the central nervous system, astrocytes have been thought to sense tissue oxygen levels in hypoxia-inducible factors (HIFs)-dependent manner and control the vascular growth into the hypoxic area by secreting VEGF. However, recent genetic evidences demonstrate that no ...