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- Podgornaya, Olga I., et al. Show all 4 Authors
- Electronic Journal of Biotechnology 2018 v.32 pp. 1-5
- DNA-binding domains; Escherichia coli; Western blotting; ammonium sulfate; biotechnology; fibroblasts; genes; guinea pigs; ion exchange chromatography; plasmids; polyclonal antibodies; polymerase chain reaction; recombinant proteins; skin (animal); telomeres
- ... TRF2 (telomeric repeat binding factor 2) is an essential component of the telomere-binding protein complex shelterin. TRF2 induces the formation of a special structure of telomeric DNA and counteracts activation of DNA damage-response pathways telomeres. TRF2 has a poorly characterized linker region (udTRF2) between its homodimerization and DNA-binding domains. Some lines of evidence have shown th ...