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- Jerrett, Michael; Brook, Robert; White, Laura F.; Burnett, Richard T.; Yu, Jeffrey; Su, Jason; Seto, Edmund; Marshall, Julian; Palmer, Julie R.; Rosenberg, Lynn; Coogan, Patricia F.
- Environment international 2017 v.102 pp. 42-47
- African Americans; United States Environmental Protection Agency; air pollution; air quality; disease incidence; insulin resistance; models; nitrogen dioxide; noninsulin-dependent diabetes mellitus; oxidative stress; ozone; particulates; prediction; quality of life; women; United States
- ... Ozone is a ubiquitous air pollutant with increasing concentrations in many populous regions. Toxicological studies show that ozone can cause oxidative stress and increase insulin resistance. These pathways may contribute to metabolic changes and diabetes formation. In this paper, we investigate the association between ozone and incident type 2 diabetes in a large cohort of African American women.W ...
- PubMed Central:
- Verner, Marc-André; Plouffe, Laurence; Kieskamp, Kyra K.; Rodríguez-Leal, Inés; Marchitti, Satori A.
- Environment international 2017 v.102 pp. 223-229
- Monte Carlo method; biological half-life; breast milk; children; decision support systems; equations; half life; lactation; regression analysis; simulation models; women
- ... Women are exposed to multiple environmental chemicals, many of which are known to transfer to breast milk during lactation. However, little is known about the influence of the different chemical-specific pharmacokinetic parameters on children's lactational dose. Our objective was to develop a generic pharmacokinetic model and subsequently quantify the influence of three chemical-specific parameter ...