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1. Complexation of plasmid DNA and poly(ethylene oxide)/poly(propylene oxide) polymers for safe gene delivery

Author:
Daima, Hemant Kumar; Shankar, Shiv; Anderson, Amanda; Periasamy, Selvakannan; Bhargava, Suresh; Bansal, Vipul
Source:
Environmental chemistry letters 2018 v.16 no.4 pp. 1457-1462
ISSN:
1610-3653
Subject:
Escherichia coli; Fourier transform infrared spectroscopy; X-ray photoelectron spectroscopy; adverse effects; composite polymers; gel electrophoresis; gene therapy; gene transfer; genes; green fluorescent protein; light scattering; mammals; nanoparticles; phosphates; plasmids; polyethylene glycol; propylene oxide; toxicity; zeta potential
Abstract:
... Gene delivery is the process of introducing foreign genetic material, such as DNA or RNA, into host cells. Gene therapy utilizes gene delivery to deliver genetic material with the goal of treating a disease or condition in the cell. Actual viral vectors may have side effects, while actual systems using metal nanoparticles for gene delivery are toxic. Therefore, we designed here a biocompatible tri ...
DOI:
10.1007/s10311-018-0756-1