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You searched for: Author "Hou, Jie" Remove constraint Author: "Hou, Jie" Journal Environmental pollution Remove constraint Journal: Environmental pollution Publication Year 2018 Remove constraint Publication Year: 2018
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1. The synergistic effects of waterborne microcystin-LR and nitrite on hepatic pathological damage, lipid peroxidation and antioxidant responses of male zebrafish

Author:
Hou, Jie,   et al.   ; Lin, Wang; Guo, Honghui; Li, Li; Wang, Lingkai; Zhang, Dandan; Li, Dapeng; Tang, Rong;     Show all 8 Authors
Source:
Environmental pollution 2018 v.235 pp. 197-206
ISSN:
0269-7491
Subject:
Danio rerio; adults; antioxidant activity; enzyme activity; eutrophication; fish; glutathione; hepatotoxicity; lakes; lipid peroxidation; liver; males; malondialdehyde; microcystin-LR; mitochondria; nitrites; oxidative stress; pollution; synergism; transferases
Abstract:
... Hazardous materials from decaying cyanobacterial blooms, such as microcystin-LR (MC-LR) and nitrite pose serious challenges to aquatic organisms. To assess combined toxic effects of MC-LR and nitrite on hepatic pathology, lipid peroxidation and antioxidant responses of fish, adult male zebrafish (Danio rerio) were exposed to solutions with different combined concentrations of MC-LR (0, 3, 30 μg/L) ...
DOI:
10.1016/j.envpol.2017.12.059

2. Estrogenic potency of MC-LR is induced via stimulating steroidogenesis: In vitro and in vivo evidence

Author:
Hou, Jie,   et al.   ; Su, Yujing; Lin, Wang; Guo, Honghui; Li, Li; Anderson, Donald M.; Li, Dapeng; Tang, Rong; Chi, Wei; Zhang, Xi;     Show all 10 Authors
Source:
Environmental pollution 2018 v.240 pp. 615-622
ISSN:
0269-7491
Subject:
Danio rerio; adults; estradiol; estrogenic properties; gene expression regulation; genes; liver; males; microcystin-LR; protein content; reproductive performance; risk; steroidogenesis; testes; testosterone; toxicity; transcription (genetics); wildlife
Abstract:
... Waterborne microcystin-LR (MC-LR) has been reported to disrupt sex hormones, while its estrogenic potency remains controversial. We hypothesized that MC-LR could induce estrogenic effects via disrupting sex hormone synthesis, and verified this hypothesis by in vitro and in vivo assays. Effects of MC-LR (1, 10, 100, 500, 1000 and 5000 μg/L) on steroidogenesis were assessed in the H295R cells after ...
DOI:
10.1016/j.envpol.2018.04.140