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- Lin, Jianping, et al. Show all 6 Authors
- Enzyme and microbial technology 2019 v.129 pp. 109355
- Escherichia coli; S-adenosylmethionine; active sites; adenosine triphosphate; catalytic activity; enzyme activity; hydrogen bonding; ligands; methionine adenosyltransferase; mutagenesis
- ... S-adenosylmethionine synthetase (MAT) catalyzes the synthesis of S-adenosylmethionine (SAM) from ATP and L-methionine. SAM is the major methyl donor for more than 100 transmethylation reactions. It is also a common cosubstrate involved in transsulfuration and aminopropylation. However, product inhibition largely restrains the activity of MAT and limits the enzymatic synthesis of SAM. In this resea ...