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- Shao, Weiping; Fernandez, Elias; Sachpatzidis, Aristidis; Wilken, Jill; Thompson, Darren A.; Schweitzer, Barry I.; Lolis, Elias
- European journal of biochemistry 2001 v.268 no.10 pp. 2948-2959
- CCR2 receptor; CCR5 receptor; Human herpesvirus 8; Human immunodeficiency virus 1; beta chemokines; epitopes; humans; macrophages; nuclear magnetic resonance spectroscopy; pathogens; sarcoma; sequence homology
- ... Human herpesvirusâ8 (HHVâ8) is the infectious agent responsible for Kaposiâs sarcoma and encodes a protein, macrophage inflammatory proteinâII (vMIPâII), which shows sequence similarity to the human CC chemokines. vMIPâII has broad receptor specificity that crosses chemokine receptor subfamilies, and inhibits HIVâ1 viral entry mediated by numerous chemokine receptors. In this study, ...
- ZederâLutz, Gabrielle; Hoebeke, Johan; Van Regenmortel, Marc H. V.
- European journal of biochemistry 2001 v.268 no.10 pp. 2856-2866
- Human immunodeficiency virus 1; epitopes; glycoproteins; humans; monoclonal antibodies; neutralization; pathogenicity; surface plasmon resonance
- ... The mechanism of infectivity neutralization of human immunodeficiency virus type 1 (HIVâ1) by Ig is poorly understood. Three human monoclonal antibodies (mAbs 1b12, 2G12 and 2F5) that are able to neutralize primary isolates of HIVâ1 in vitro have been shown to act synergistically. In the present study this synergy was analyzed by measuring the epitope accessibility and binding kinetics for the ...