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- Leeksma, Onno C.; van Achterberg, Tanja A. E.; Tsumura, Yoshikazu; Toshima, Jiro; Eldering, Eric; Kroes, Wilma G. M.; Mellink, Clemens; Spaargaren, Marcel; Mizuno, Kensaku; Pannekoek, Hans; de Vries, Carlie J. M.
- European journal of biochemistry 2002 v.269 no.10 pp. 2546-2556
- umbilical arteries, etc ; Drosophila melanogaster; antagonists; cDNA libraries; complementary DNA; epidermal growth factor; fibroblast growth factors; genes; humans; liver; mice; mitogen-activated protein kinase; myocytes; plasma membrane; receptor protein-tyrosine kinase; receptors; reverse transcriptase polymerase chain reaction; signal transduction; smooth muscle; two hybrid system techniques; tyrosine; Show all 21 Subjects
- ... The Drosophila melanogaster protein sprouty is induced upon fibroblast growth factor (FGF)â and epidermal growth factor (EGF)âreceptor tyrosine kinase activation and acts as an inhibitor of the ras/MAP kinase pathway downstream of these receptors. By differential display RTâPCR of activated vs. resting umbilical artery smooth muscle cells (SMCs) we detected a new human sprouty gene, which we ...