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- Pappa, Aglaia, et al. Show all 9 Authors
- European journal of nutrition 2020 v.59 no.2 pp. 557-569
- acetylation; acetyltransferases; allyl isothiocyanate; apoptosis; bioactive properties; biological models; brain; carcinoma; cell viability; epigenetics; gene expression; gene expression regulation; genes; histone deacetylase; histones; human cell lines; immunoblotting; keratinocytes; lymph nodes; lysine; melanoma; metastasis; methylation; mice; protein synthesis; secondary metabolites
- ... OBJECTIVE(S): Isothiocyanates (ITCs) are biologically active plant secondary metabolites capable of mediating various biological effects including modulation of the epigenome. Our aim was to characterize the effect of allyl isothiocyanate (AITC) on lysine acetylation and methylation marks as a potential epigenetic-induced anti-melanoma strategy. METHODS: Our malignant melanoma model consisted of ( ...
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