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- Rodríguez, Juliana; Mandalunis, Patricia Mónica
- Experimental and toxicologic pathology 2016 v.68 no.7 pp. 391-397
- acid phosphatase; adipocytes; bone marrow; cadmium; cartilage; euthanasia; experimental design; males; mastication; osteoblasts; osteoclasts; osteoporosis; protective effect; rats; renal failure; staining; t-test; tibia; toxicity; vitamin D
- ... Accumulation of cadmium (Cd), an extremely toxic metal, can cause renal failure, decreased vitamin D synthesis, and consequently osteoporosis. The aim of this work was to evaluate the effect of Cd on two types of bone in growing Wistar rats. Sixteen 21-day-old male Wistar rats were assigned to one of two groups. The Cd group subcutaneously received 0.5mg/kg of CdCl2 5 times weekly for 3 months. Th ...
- Yoshizawa, Katsuhiko; Yuki, Michiko; Kinoshita, Yuichi; Emoto, Yuko; Yuri, Takashi; Elmore, Susan A.; Tsubura, Airo
- Experimental and toxicologic pathology 2016 v.68 no.7 pp. 371-379
- N-methyl-N-nitrosourea; abdominal cavity; actin; carcinogenicity; desmin; immunohistochemistry; males; mesentery; myoglobin; neoplasms; nerve growth factor; pancreas; peripheral nervous system; rats; retrospective studies; smooth muscle; thoracic cavity; thymus gland; vimentin
- ... N-methyl-N-nitrosourea (MNU) possesses peripheral nervous system carcinogenic activity in rats and induces benign and malignant schwannomas in systemic organs. In this retrospective study, we compared the characteristics of various immunohistochemical markers in MNU-induced schwannomas in male Crj:CD(SD)IGS rats including: vimentin (Vim), S100, p75 nerve growth factor receptor (LNGFR), CD57, pancy ...