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- Kikuchihara, Yoh; Onda, Nobuhiko; Kimura, Masayuki; Kangawa, Yumi; Mizukami, Sayaka; Yoshida, Toshinori; Shibutani, Makoto
- Experimental and toxicologic pathology 2015 v.67 no.5-6 pp. 349-353
- azoxymethane; carcinogens; colorectal neoplasms; epithelial cells; immunohistochemistry; intestinal mucosa; mice; morphogenesis; mucins; rats; small intestine; staining; stomach
- ... Azoxymethane (AOM) is a potent carcinogen used for induction of colon tumors in rats and mice. It is also known that AOM treatment induces small bowel tumors in addition to colorectal tumors in rats. The present study examined the histogenesis of AOM-induced rat duodenal tumors in comparison with concurrently induced colorectal tumors by histochemical and immunohistochemical approaches. Duodenal a ...
- Yang, Honglian; Kong, Qingxi; Liu, Huanliang; Zhang, Wei; Tian, Lei; Lin, Bencheng; Fang, Yanjun; Xi, Zhuge
- Experimental and toxicologic pathology 2015 v.67 no.5-6 pp. 341-347
- adenoma; body weight; carcinogens; chemistry; diet; females; fungicides; hematology; hyperplasia; lesions (animal); males; necropsy; rats; thiazoles; thyroid gland; toxicity; weight gain; zinc
- ... Thiazole–Zn is a newly created Chinese systemic fungicide that is a thiadiazole compound. The toxicity of thiazole–Zn was examined in Sprague-Dawley rats fed diets containing 0, 4, 20 and 100mg/kg thiazole–Zn for one year. Lower body weight gains were noted in both males and females of the 100mg/kg diet group. Moreover, we show that the toxicity of thiazole–Zn was low, as evidenced by the absence ...