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You searched for: Journal name FEBS Open Bio Remove constraint Journal name: FEBS Open Bio Publication year rev 7980-2020 Remove constraint Publication year rev: 7980-2020 Source 2020 v.10 no.5 Remove constraint Source: 2020 v.10 no.5
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1. CNOT7 depletion reverses natural killer cell resistance by modulating the tumor immune microenvironment of hepatocellular carcinoma

Author:
Chongren Ren; Xiaojing Ren; Dujuan Cao; Haichao Zhao; Zhensheng Zhai; Huiyu Li; Yanjun Li; Xifeng Fu; Jiefeng He; Haoliang Zhao
Source:
FEBS Open Bio 2020 v.10 no.5 pp. 847-860
ISSN:
2211-5463
Subject:
Hepatitis B virus; adjuvants; caspase-3; cytokines; hepatoma; immunotherapy; natural killer cells; prognosis; secretion
Abstract:
... A major obstacle to effective cancer immunotherapy is the tumor immune microenvironment. Natural killer (NK) cell resistance has been suggested as a primary cause of poor prognosis in hepatocellular carcinoma (HCC), which seemingly correlates with CNOT7 overexpression. CNOT7, a cytoplasmic mRNA deadenylase that is highly expressed in HCC, may regulate cytokine transforming growth factor‐β1 (TGF‐β1 ...
DOI:
10.1002/2211-5463.12836

2. Deregulation of miR‐27a may contribute to canine fibroblast activation after coculture with a mast cell tumour cell line

Author:
Matias Aguilera‐Rojas; Soroush Sharbati; Torsten Stein; Ralf Einspanier
Source:
FEBS Open Bio 2020 v.10 no.5 pp. 802-816
ISSN:
2211-5463
Subject:
RNA interference; actin; carcinogenesis; cell growth; cell lines; coculture; cyclins; dogs; exosomes; extracellular matrix; fibroblasts; interleukin-6; mast cells; microRNA; muscles; neoplasm cells; neoplasms; protein content
Abstract:
... The tumour microenvironment comprises a diverse range of cells, including fibroblasts, immune cells and endothelial cells, along with extracellular matrix. In particular, fibroblasts are of significant interest as these cells are reprogrammed during tumorigenesis to become cancer‐associated fibroblasts (CAFs), which in turn support cancer cell growth. MicroRNAs (miRNAs) have been shown to be invol ...
DOI:
10.1002/2211-5463.12831

3. Development of a novel murine heart failure model overexpressing human renin and angiotensinogen

Author:
Tomoya Hara; Takeshi Yamamura; Mirei Murakami‐Asahina; Hirokazu Matsumoto; Michiyasu Takeyama; Ray Kanagawa; Tomoyuki Nishimoto
Source:
FEBS Open Bio 2020 v.10 no.5 pp. 718-725
ISSN:
2211-5463
Subject:
active sites; amino acid sequences; angiotensinogen; cardioprotective effect; crossing; drugs; genetically modified organisms; heart failure; humans; hypertrophy; mice; models; renin; renin-angiotensin system; survival rate
Abstract:
... Renin is the rate‐limiting enzyme of the renin–angiotensin system cascade, which drives the pathophysiological progression of heart failure. Species differences in the amino acid sequence of the catalytic domain of renin limit evaluations of the potency and efficacy of human renin inhibitors in animal models, and a high dose of inhibitors is usually needed to show its organ‐protective effects in r ...
DOI:
10.1002/2211-5463.12810

4. Down‐regulation of anti‐inflammatory TIPE2 may aggravate adenoidal hypertrophy in children

Author:
Kun Gao; Yanzhong Li; Zhiyong Yue; Jie Han; Xuanchen Zhou; Xiaoting Wang
Source:
FEBS Open Bio 2020 v.10 no.5 pp. 761-766
ISSN:
2211-5463
Subject:
humans; hypertrophy; interleukin-6; monocytes; mouth; nose; pathogenesis; sleep apnea; speech; tumor necrosis factor-alpha
Abstract:
... Adenoidal hypertrophy (AH) is a common disorder in the pediatric population, with common symptoms including mouth breathing, nasal congestion, hyponasal speech, snoring and obstructive sleep apnea. Although the pathogenesis of AH has not been fully elucidated, recent studies have indicated that immune responses may play an important role in AH. Tumor necrosis factor‐alpha (TNF‐α)‐induced protein‐8 ...
DOI:
10.1002/2211-5463.12821

5. Engineered Escherichia coli strains as platforms for biological production of isoprene

Author:
Hyeok‐Won Lee; Jung‐Ho Park; Won‐Kyo Kim; Jin‐Gyeom Lee; Ju‐Seok Lee; Jung‐Oh Ahn; Eun‐Gyo Lee; Hong‐Weon Lee
Source:
FEBS Open Bio 2020 v.10 no.5 pp. 780-788
ISSN:
2211-5463
Subject:
Escherichia coli; biological production; fermentation; fuels; genetic engineering; isoprene
Abstract:
... Volatile compounds can be produced by fermentation from genetically engineered microorganisms. Escherichia coli strains are mainly used for isoprene production owing to their higher titers; however, this has thus far been confined to only strains BL21, BL21 (DE3), Rosetta, and BW25113. Here, we tested four groups of E. coli strains for improved isoprene production, including K‐12 (DH5α, BW25113, W ...
DOI:
10.1002/2211-5463.12829

6. Interferon‐γ‐induced HLA Class II expression on endothelial cells is decreased by inhibition of mTOR and HMG‐CoA reductase

Author:
Akihiro Maenaka; Iwasaki Kenta; Akinobu Ota; Yuko Miwa; Wataru Ohashi; Kosei Horimi; Yutaka Matsuoka; Masafumi Ohnishi; Kazuharu Uchida; Takaaki Kobayashi
Source:
FEBS Open Bio 2020 v.10 no.5 pp. 927-936
ISSN:
2211-5463
Subject:
HLA antigens; antibodies; cyclosporine; cytosol; graft rejection; organ transplantation; oxidoreductases; prednisolone; tacrolimus; transcription (genetics)
Abstract:
... In organ transplantation, donor‐specific HLA antibody (DSA) is considered a major cause of graft rejection. Because DSA targets primarily donor‐specific human leukocyte antigen (HLA) expressed on graft endothelial cells, the prevention of its expression is a possible strategy for avoiding or salvaging DSA‐mediated graft rejection. We examined the effect of various clinically used drugs on HLA clas ...
DOI:
10.1002/2211-5463.12854

7. Iron overload inhibits self‐renewal of human pluripotent stem cells via DNA damage and generation of reactive oxygen species

Author:
Zhenbo Han; Zihang Xu; Lei Chen; Danyu Ye; Yang Yu; Ying Zhang; Yang Cao; Bamba Djibril; Xiaofei Guo; Xinlu Gao; Wenwen Zhang; Meixi Yu; Shenzhen Liu; Gege Yan; Mengyu Jin; Qi Huang; Xiuxiu Wang; Bingjie Hua; Chao Feng; Fan Yang; Wenya Ma; Yu Liu
Source:
FEBS Open Bio 2020 v.10 no.5 pp. 726-733
ISSN:
2211-5463
Subject:
DNA damage; ammonium; cell cycle checkpoints; citrates; deferoxamine; homeostasis; humans; iron overload; reactive oxygen species
Abstract:
... Iron overload affects the cell cycle of various cell types, but the effect of iron overload on human pluripotent stem cells has not yet been reported. Here, we show that the proliferation capacities of human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs) were significantly inhibited by ferric ammonium citrate (FAC) in a concentration‐dependent manner. In addition, d ...
DOI:
10.1002/2211-5463.12811

8. LCK expression is a potential biomarker for distinguishing primary central nervous system lymphoma from glioblastoma multiforme

Author:
Le Ge; Lixia Xu; Shan Lu; Hua Yan
Source:
FEBS Open Bio 2020 v.10 no.5 pp. 904-911
ISSN:
2211-5463
Subject:
B-cell lymphoma; bioinformatics; biomarkers; central nervous system; gene expression; glioblastoma; immunohistochemistry; non-specific protein-tyrosine kinase; prognosis; proteome
Abstract:
... Glioblastoma multiforme (GBM) and primary central nervous system lymphoma (PCNSL) are both malignant cerebral tumors; however, their treatments are vastly different. Early and precise diagnosis is vital for subsequent adequate treatment to improve prognosis. Reliable biomarkers that can easily distinguish GBM and PCNSL are urgently needed. We evaluated the diagnostic potential of lymphocyte‐specif ...
DOI:
10.1002/2211-5463.12849

9. LncRNA EGOT decreases breast cancer cell viability and migration via inactivation of the Hedgehog pathway

Author:
Shuang Qiu; Guobing Chen; Juan Peng; Jia Liu; Jumin Chen; Jianjun Wang; Li Li; Kunxian Yang
Source:
FEBS Open Bio 2020 v.10 no.5 pp. 817-826
ISSN:
2211-5463
Subject:
Erinaceidae; agonists; breast neoplasms; cell viability; glioma; neoplasm cells; non-coding RNA; ontogeny; plasmids; stomach neoplasms
Abstract:
... The long noncoding RNA (lncRNA) Eosinophil Granule Ontogeny Transcript (EGOT) has been reported to inhibit the proliferation and migration of glioma cells, and promote the development and progression of gastric cancer through the Hedgehog (Hh) signaling pathway. This study was conducted to assess the role of EGOT in the progression of breast cancer. We observed that EGOT is significantly down‐regu ...
DOI:
10.1002/2211-5463.12833

10. Origin and adaptation of green‐sensitive (RH2) pigments in vertebrates

Author:
Shozo Yokoyama; Huiyong Jia
Source:
FEBS Open Bio 2020 v.10 no.5 pp. 873-882
ISSN:
2211-5463
Subject:
absorption; amino acid substitution; ancestry; evolution; genes; vertebrates
Abstract:
... One of the critical times for the survival of animals is twilight where the most abundant visible lights are between 400 and 550 nanometres (nm). Green‐sensitive RH2 pigments help nonmammalian vertebrate species to better discriminate wavelengths in this blue‐green region. Here, evaluation of the wavelengths of maximal absorption (λₘₐₓs) of genetically engineered RH2 pigments representing 13 criti ...
DOI:
10.1002/2211-5463.12843

11. TAS‐115 inhibits PDGFRα/AXL/FLT‐3 signaling and suppresses lung metastasis of osteosarcoma

Author:
Naohiro Yasuda; Satoshi Takenaka; Sho Nakai; Takaaki Nakai; Shutaro Yamada; Yoshinori Imura; Hidetatsu Outani; Kenichiro Hamada; Hideki Yoshikawa; Norifumi Naka
Source:
FEBS Open Bio 2020 v.10 no.5 pp. 767-779
ISSN:
2211-5463
Subject:
adolescence; cell lines; childhood; humans; lungs; metastasis; mice; osteosarcoma; phosphorylation; platelet-derived growth factor receptor alpha; prognosis; survival rate; tyrosine
Abstract:
... Osteosarcoma is the most common malignant bone tumor in adolescence and childhood. Metastatic osteosarcoma has a poor prognosis with an overall 5‐year survival rate of approximately 20%. TAS‐115 is a novel multiple receptor tyrosine kinase inhibitor that is currently undergoing clinical trials. Using the mouse highly lung‐metastatic osteosarcoma cell line, LM8, we showed that TAS‐115 suppressed th ...
DOI:
10.1002/2211-5463.12827

12. Tracing the evolution of fatty acid‐binding proteins (FABPs) in organisms with a heterogeneous fat distribution

Author:
Yuru Zhang; Junmei Zhang; Yanhua Ren; Ronghua Lu; Liping Yang; Guoxing Nie
Source:
FEBS Open Bio 2020 v.10 no.5 pp. 861-872
ISSN:
2211-5463
Subject:
Caenorhabditis elegans; ancestry; fatty acid-binding proteins; genes; genomics; invertebrates; phylogeny; vertebrates
Abstract:
... The distribution of fat among both invertebrate and vertebrate groups is heterogeneous. Studies have shown that fatty acid‐binding proteins (FABPs), which mainly bind and transport fatty acids, play important roles in the regulation of fat storage and distribution. However, the systematic and genome‐wide investigation of FABP genes in organisms with a heterogeneous fat distribution remains in its ...
DOI:
10.1002/2211-5463.12840

13. From astrocytoma to glioblastoma: a clonal evolution study

Author:
Fuhua Yang; Yunding Zou; Qiang Gong; Jieping Chen; Wei‐Dong Li; Qilin Huang
Source:
FEBS Open Bio 2020 v.10 no.5 pp. 744-751
ISSN:
2211-5463
Subject:
DNA; DNA repair; World Health Organization; blood sampling; computer software; drug therapy; evolution; germ cells; glioblastoma; heterozygosity; homozygosity; missense mutation; neoplasm progression; nonsense mutation; patients; relapse; resection
Abstract:
... Astrocytomas often recur after surgical resection, but the underlying mechanism remains enigmatic. Elucidation of clonal evolution in primary and relapse tumors may provide important information on tumor progression. Here, we examined genetic factors underlying recurrence in a patient with astrocytoma initially diagnosed with World Health Organization (WHO) grade II astrocytoma, who then relapsed ...
DOI:
10.1002/2211-5463.12815

14. Hypoxia potentiates the capacity of melanoma cells to evade cisplatin and doxorubicin cytotoxicity via glycolytic shift

Author:
Ming Zhuo; Falih M. Gorgun; Douglas S. Tyler; Ella W. Englander
Source:
FEBS Open Bio 2020 v.10 no.5 pp. 789-801
ISSN:
2211-5463
Subject:
cell death; cisplatin; cytotoxicity; doxorubicin; drug therapy; glycolysis; hypoxia; melanoma; mitochondria
Abstract:
... The hypoxic environment within solid tumors impedes the efficacy of chemotherapeutic treatments. Here, we demonstrate that hypoxia augments the capacity of melanoma cells to withstand cisplatin and doxorubicin cytotoxicity. We show that B16F10 cells derived from spontaneously formed melanoma and YUMM1.7 cells, engineered to recapitulate human‐relevant melanoma driver mutations, profoundly differ i ...
DOI:
10.1002/2211-5463.12830

15. Interhemispheric asymmetry of c‐Fos expression in glomeruli and the olfactory tubercle following repeated odor stimulation

Author:
YoonGyu Jae; NaHye Lee; Dae Won Moon; JaeHyung Koo
Source:
FEBS Open Bio 2020 v.10 no.5 pp. 912-926
ISSN:
2211-5463
Subject:
asymmetry; cortex; mammals; neurons; odor compounds; odors; olfactory bulb; sensation
Abstract:
... Odor adaptation allows the olfactory system to regulate sensitivity to different stimulus intensities, which is essential for preventing saturation of the cell‐transducing machinery and maintaining high sensitivity to persistent and repetitive odor stimuli. Although many studies have investigated the structure and mechanisms of the mammalian olfactory system that responds to chemical sensation, fe ...
DOI:
10.1002/2211-5463.12851

16. Interleukin‐36α as a potential biomarker for renal tubular damage induced by dietary phosphate load

Author:
Yoshitaka Hirano; Hiroshi Kurosu; Kazuhiro Shiizaki; Yoshitaka Iwazu; Shuichi Tsuruoka; Makoto Kuro‐o
Source:
FEBS Open Bio 2020 v.10 no.5 pp. 894-903
ISSN:
2211-5463
Subject:
RNA; acute kidney injury; biomarkers; cytokines; diet; excretion; gene expression; genes; immunohistochemistry; inflammation; kidneys; neutrophils; osteopontin; phosphates
Abstract:
... Excessive intake of phosphate has been known to induce renal tubular damage and interstitial inflammation, leading to acute kidney injury or chronic kidney disease in rodents and humans. However, sensitive and early biomarkers for phosphate‐induced kidney damage remain to be identified. Our previous RNA sequencing analysis of renal gene expression identified interleukin‐36α (IL‐36α) as a gene sign ...
DOI:
10.1002/2211-5463.12845

17. PBK attenuates paclitaxel‐induced autophagic cell death by suppressing p53 in H460 non‐small‐cell lung cancer cells

Author:
Jung‐Hwan Park; Sang‐Ah Park; Young‐Ju Lee; Hwan‐Woo Park; Sang‐Muk Oh
Source:
FEBS Open Bio 2020 v.10 no.5 pp. 937-950
ISSN:
2211-5463
Subject:
apoptosis; autophagy; lung neoplasms; neoplasm cells; paclitaxel; physiological transport; transcription (genetics); ubiquitination
Abstract:
... PDZ‐binding kinase (PBK) has previously been shown to mediate chemoresistance of cancer cells to anticancer drugs. However, it remains unclear how PBK regulates paclitaxel‐induced cancer cell death. Here, we demonstrate that PBK hinders paclitaxel‐mediated autophagic cell death in H460 non‐small‐cell lung cancer cells. PBK knockdown increased apoptosis, autophagy, p53 level, and LC3 puncta upon pa ...
DOI:
10.1002/2211-5463.12855

18. Potential sources of interference with the highly sensitive detection and quantification of alpha‐synuclein seeds by qRT‐QuIC

Author:
Viktoria C. Ruf; Song Shi; Felix Schmidt; Daniel Weckbecker; Georg S. Nübling; Uwe Ködel; Brit Mollenhauer; Armin Giese
Source:
FEBS Open Bio 2020 v.10 no.5 pp. 883-893
ISSN:
2211-5463
Subject:
biomarkers; blood; brain; cerebrospinal fluid; freeze-thaw cycles; genetic techniques and protocols; neurodegenerative diseases; seeds
Abstract:
... Parkinson’s disease (PD) is a progressive neurodegenerative disease which is histologically characterized by loss of dopaminergic neurons in the substantia nigra and deposition of aggregated alpha‐synuclein (aSyn) in the brain. The detection of aSyn in well accessible fluids has been one of the central approaches in the development of biomarkers for PD. Recently, real‐time quaking‐induced conversi ...
DOI:
10.1002/2211-5463.12844

19. Pyruvate alleviates high glucose‐induced endoplasmic reticulum stress and apoptosis in HK‐2 cells

Author:
Xiao Meng Zhang; Yi Zhen Wang; Jin Dong Tong; Xu Chao Ning; Fang Qiang Zhou; Xiu Hong Yang; Hui Min Jin
Source:
FEBS Open Bio 2020 v.10 no.5 pp. 827-834
ISSN:
2211-5463
Subject:
apoptosis; diabetic nephropathy; endoplasmic reticulum; endoplasmic reticulum stress; glucose; oral rehydration; pyruvic acid; reactive oxygen species
Abstract:
... Endoplasmic reticulum (ER) stress plays a critical role in the development of diabetic nephropathy (DN). We previously demonstrated that pyruvate (Pyr)‐enriched oral rehydration solution improved glucometabolic disorders and ameliorated DN outcome in db/db mice. Here, we investigated the effects of Pyr on high glucose‐induced ER stress and apoptosis in HK‐2 cells. Our results suggest that high glu ...
DOI:
10.1002/2211-5463.12834

20. Serpin7 controls egg diapause of migratory locust (Locusta migratoria) by regulating polyphenol oxidase

Author:
Jun Chen; Dongnan Cui; Hidayat Ullah; Kun Hao; Xiongbing Tu; Zehua Zhang
Source:
FEBS Open Bio 2020 v.10 no.5 pp. 707-717
ISSN:
2211-5463
Subject:
Locusta migratoria; blood coagulation; catechol oxidase; complement; diapause; double-stranded RNA; eggs; energy metabolism; extracellular matrix; fibrinolysis; genes; insects; migratory behavior; proteomics; serine proteinases; serpins; transcriptomics
Abstract:
... Diapause is a state of arrested growth, which allows insects to adapt to diverse environments. Serine protease inhibitors (serpins) play an important role in various physiological processes, including blood coagulation, fibrinolysis, development, complement activation and extracellular matrix remodeling. We hypothesized that serpin may affect energy metabolism and thereby control diapause of migra ...
DOI:
10.1002/2211-5463.12825